ID B3S4B6_TRIAD Unreviewed; 746 AA.
AC B3S4B6;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=TRIADDRAFT_59025 {ECO:0000313|EMBL:EDV22611.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV22611.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV22611.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV22611.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS985249; EDV22611.1; -; Genomic_DNA.
DR RefSeq; XP_002115155.1; XM_002115119.1.
DR AlphaFoldDB; B3S4B6; -.
DR STRING; 10228.B3S4B6; -.
DR EnsemblMetazoa; TriadT59025; TriadP59025; TriadG59025.
DR GeneID; 6756367; -.
DR KEGG; tad:TRIADDRAFT_59025; -.
DR CTD; 6756367; -.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_005240_2_0_1; -.
DR InParanoid; B3S4B6; -.
DR OMA; EITSITM; -.
DR OrthoDB; 2970339at2759; -.
DR PhylomeDB; B3S4B6; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 406..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 406..672
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 746 AA; 85697 MW; 0F5177B30868B001 CRC64;
MALRDINNRS DILPGYKLDV IIKDTKHNSF HAVKEFFDLV SKPPKKYLIY GPIQSANCEA
VAPITKYWNL ITFSPSATSM KLANKKTYSN FFRTSISDFS YNPARIAVMK HFNWTRIGLI
SQVTDLFTYA AKDLEKLASR EDIQVVSSES FTDDPTFTIS QLKEKDVRII VLNAYPAQIL
QVLCSAYLYK LYGAQYVWFL PGWFFENWIF DNYRPKTFNY NCTMAQLLEV ADYYIAFKGV
TLPRLSEPRL AGYTAEGFNK EYINFGDKIH LSGSYTYAYD AAWTIALALN RTREILQRNY
SRSLDDFNYN DSTTMNILQR AINDVQFIGV SGKIVFQDGN RLGNVRIMQY QRKVYINYTV
TVGFYDVFEK KLFFSNYKNK ITFKGNYTPV DHAKRIIRRL SVGKEIFAIF ATLSSLGTLL
SLFMITFNVT YRSVRQVKIT SPRVNVMLLL GCVLCYLSVI LLGLDWNLIS SKTFIASCTA
AVWLLSIGFT LGFGSLFWKT WRVYAIYKSK SPKRKIIRDI HILPRLAVLL VIDIIILSLW
QIIDPMRTIE NSILSKHTSS IGDYEITSIT MVCQSVNMPI WLGVIYGYKF VLMIFGAFLA
WETRHVNIQE INDSKLIGLS IYNVALLCTV GVILYQFTTA EPSTSYSIVS SFIIFCNTVT
ICIIFIPMIR NVKEGRDVTS FYANRTNKVR SNTKEGINGT INTVDVTTYK REIEQQNEIV
YKLKQFILAN NINVQESEEI RSLFST
//
