ID B3VUH7_CULQU Unreviewed; 2101 AA.
AC B3VUH7;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176 {ECO:0000313|EMBL:ACF04201.1};
RN [1] {ECO:0000313|EMBL:ACF04201.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S-Lab {ECO:0000313|EMBL:ACF04201.1};
RA Xu Q., Zhang L., Liu N.;
RT "Adaptive changes in amino acid and codon biases of the mosquito sodium
RT channel in the evolution of permethrin selection.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; EU817517; ACF04201.1; -; mRNA.
DR VEuPathDB; VectorBase:CPIJ004995; -.
DR VEuPathDB; VectorBase:CPIJ007595; -.
DR VEuPathDB; VectorBase:CPIJ007596; -.
DR VEuPathDB; VectorBase:CPIJ007598; -.
DR VEuPathDB; VectorBase:CPIJ017896; -.
DR VEuPathDB; VectorBase:CQUJHB005371; -.
DR HOGENOM; CLU_000540_5_1_1; -.
DR InParanoid; B3VUH7; -.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:ACF04201.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 144..171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 215..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 249..267
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 273..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 404..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 809..832
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 853..876
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 882..906
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 937..959
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1017..1038
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1327..1349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1355..1381
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1402..1433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1522..1546
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1609..1627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1639..1658
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1670..1689
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1733..1756
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1826..1846
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1863..1898
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 36..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1990..2069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2082..2101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 430..468
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 36..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1227
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2086..2101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2101 AA; 235310 MW; 6C33BC9DE1F13170 CRC64;
MTEDLDSISE EERSLFRPFT RESLLVIEER IANEQAKQRE LEKKRAEGET GFGRKKKKKE
IRYDDEDEDE GPQPDSTLEQ GVPIPVRMQG SFPPELASTP LEDIDAFYAN IKTFVVVSKG
KDIFRFSATN ALYVLDPFNP IRRVAIYILV HPLFSFFIIT TILGNCILMI MPSTPTVEST
EVIFTGIYTF ESAVKVMARG FILQPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT
FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC
IKEFPTDGSW GNLTHENWER HHSNDSNWYF SETGDTPLCG NSSGAGQCEE GYVCLQGFGD
NPNYGYTSFD TFGWAFLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI IFLGSFYLVN
LILAIVAMSY DELQKRAEEE EAAEEEALRE AEEAAAAKQA KLEAHAAAAA AAANPEIAKS
PSDFSCHSYE LFVGQEKGND DNNKEKMSIR SEGLESVSEI TRTTAPTATA AGTAKARKVS
AASLSLPGSP FNLRRGSRGS HQFTIRNGRG RFVGVPGSDR KPLVLSTYLD AQEHLPYADD
SNAVTPMSEE NGAIIVPVYY ANLGSRHSSY TSHQSRISYT SHGDLLGGMT KESRLRSRTQ
RNTNHSIVPP ANMAASAASV TGAGSGAPNM SYVDTNHKGQ QRDFDQSQDY TDDAGKIKHN
DNPFIEPSQT QTVVDMKDVM VLNDIIEQAA GRHSRASDHG VSVYYFPTED DDEDGPTFKD
KAVEFGMRMI DIFCVWDCCW VWLKFQEWVS FIVFDPFVEL FITLCIVVNT LFMALDHHDM
NPDMERALKS GNYFFTATFA IEATMKLIAM SPKWYFQEGW NIFDFIIVAL SLLELGLEGV
QGLSVLRSFR LLRVFKLAKS WPTLNLLISI MGRTMGALGN LTFVLCIIIF IFAVMGMQLF
GKNYIDNVDR FPDKDLPRWN FTDFMHSFMI VFRVLCGEWI ESMWDCMLVG DVSCIPFFLA
TVVIGNLVVL NLFLALLLSN FGSSSLSAPT ADNETNKIAE AFNRISRFSN WIKANIAAAL
KFVKNKLTSQ IASVQPAGKG VCPCISAEHG ENELELTPDD ILADGLLKKG VKEHNQLEVA
IGDGMEFTIH GDLKNKGKKN KQLMNNSKDD DTASIKSYGS HKNRPFKDES HKGSAETLEG
EEKRDASKED LGIDEELDDE CEGEEGPLDG EMIIHAEEDE VIEDAPADCF PDNCYKRFPA
LAGDDDAPFW QGWGNLRLKT FQLIENKYFE TAVITMILLS SLALALEDVH LPHRPILQDV
LYYMDRIFTV IFFLEMLIKW LALGFRVYFT NAWCWLDFII VMVSLINFVA SLCGAGGIQA
FKTMRTLRAL RPLRAMSRMQ GMRVVVNALV QAIPSIFNVL LVCLIFWLIF AIMGVQLFAG
KYFKCVDTNK TTLSHEIIPD VNACIAENYT WENSPMNFDH VGKAYLCLFQ VATFKGWIQI
MNDAIDSRDI GKQPIRETNI YMYLYFVFFI IFGSFFTLNL FIGVIIDNFN EQKKKAGGSL
EMFMTEDQKK YYNAMKKMGS KKPLKAIPRP KWRPQAIVFE ICTNKKFDMI IMLFIGFNML
TMTLDHYKQT ETFSAVLDYL NMIFICIFSS ECLMKIFALR YHYFIEPWNL FDFVVVILSI
LGLVLSDLIE KYFVSPTLLR VVRVAKVGRV LRLVKGAKGI RTLLFALAMS LPALFNICLL
LFLVMFIFAI FGMSFFMHVK DKSGLDDVYN FKTFGQSMIL DKSGLDDVYN FKTFGQSMIL
EDCLPPDNDK GYPGNCGSAT IGITYLLAYL VISFLIVINM YIAVILENYS QATEDVQEGL
TDDDYDMYYE IWQQFDPDGT QYIRYDQLSD FLDVLEPPLQ IHKPNKYKII SMDIPICRGD
MMFCVDILDA LTKDFFARKG NPIEDSAEMG EVQQRPDEVG YEPVSSTLWR QREEYCARLI
QHAYRNFKER GGVGGGGGGG GGGGGGGGEG AGDDTDADAC DNEPGIGSPG AVSGGGGSIA
GGGSQANLGP PSPKESPDGN NDPQGRQTAV LVESDGFVTK NGHRVVIHSR SPSITSRSAD
V
//
