ID B4DSU5_HUMAN Unreviewed; 540 AA.
AC B4DSU5;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=cDNA FLJ55583, highly similar to Polypyrimidine tract-binding protein 2 {ECO:0000313|EMBL:BAG61757.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG61757.1};
RN [1] {ECO:0000313|EMBL:BAG61757.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAG61757.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK299922; BAG61757.1; -; mRNA.
DR RefSeq; NP_001287915.1; NM_001300986.1.
DR AlphaFoldDB; B4DSU5; -.
DR PeptideAtlas; B4DSU5; -.
DR DNASU; 58155; -.
DR GeneID; 58155; -.
DR CTD; 58155; -.
DR OrthoDB; 4825346at2759; -.
DR BioGRID-ORCS; 58155; 19 hits in 1169 CRISPR screens.
DR GenomeRNAi; 58155; -.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:UniProt.
DR CDD; cd12778; RRM1_PTBP2; 1.
DR CDD; cd12783; RRM2_PTBP2; 1.
DR CDD; cd12696; RRM3_PTBP2; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035002; PTBP2_RRM1.
DR InterPro; IPR034799; PTBP2_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF16; POLYPYRIMIDINE TRACT-BINDING PROTEIN 2; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 2: Evidence at transcript level;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 67..141
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 189..265
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 346..420
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 463..538
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 540 AA; 58632 MW; 9BCB769B376EC9BB CRC64;
MDGYVIGPAR RIVTEVAVGV KRGSDELLSG SVLSSPNSNM SSMVVTANGN DSKKFKGEDK
MDGAPSRVLH IRKLPGEVTE TEVIALGLPF GKVTNILMLK EKNQAFLELA TEEAAITMVN
YYSAVTPHLR NQPIYIQYSN HKELKTDNTL NQRAQAVLQA VTAVQTANTP LSGTTVSESA
VTPAQSPVLR IIIDNMYYPV TLDVLHQIFS KFGAVLKIIT FTKNNQFQAL LQYGDPVNAQ
QAKLALDGQN IYNACCTLRI DFSKLVNLNV KYNNDKSRDY TRPDLPSGDG QPALDPAIAA
AFAKETSLLA VPGALSPLAI PNAAAAAAAA AAGRVGMPGV SAGGNTVLLV SNLNEEMVTP
QSLFTLFGVY GDVQRVKILY NKKDSALIQM ADGNQSQLAM NHLNGQKMYG KIIRVTLSKH
QTVQLPREGL DDQGLTKDFG NSPLHRFKKP GSKNFQNIFP PSATLHLSNI PPSVAEEDLR
TLFANTGGTV KAFKFFQRDH KMALLQMATV EEAIQALIDL HNYNLGENHH LRVSFSKSTI
//
