ID B4E021_HUMAN Unreviewed; 404 AA.
AC B4E021;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Integrin subunit alpha L {ECO:0000313|Ensembl:ENSP00000409377.2};
DE SubName: Full=cDNA FLJ57691, highly similar to Integrin alpha-L {ECO:0000313|EMBL:BAG64283.1};
GN Name=ITGAL {ECO:0000313|Ensembl:ENSP00000409377.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG64283.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000409377.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0000313|EMBL:BAG64283.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:BAG64283.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSP00000409377.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC002310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC116348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK303190; BAG64283.1; -; mRNA.
DR ProteomicsDB; 5639; -.
DR Antibodypedia; 13698; 2405 antibodies from 47 providers.
DR Ensembl; ENST00000433423.2; ENSP00000409377.2; ENSG00000005844.19.
DR UCSC; uc010vev.3; human.
DR HGNC; HGNC:6148; ITGAL.
DR VEuPathDB; HostDB:ENSG00000005844; -.
DR GeneTree; ENSGT00940000161495; -.
DR HOGENOM; CLU_681459_0_0_1; -.
DR ChiTaRS; ITGAL; human.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000005844; Expressed in granulocyte and 176 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.2120; -; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF84; INTEGRIN ALPHA-L; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 1: Evidence at protein level;
KW Integrin {ECO:0000313|EMBL:BAG64283.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:B4E021,
KW ECO:0007829|PeptideAtlas:B4E021};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 362..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 44843 MW; F3F09BB04F11E1C5 CRC64;
MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QIKSLIPQFQ
GRLVANLTYT LQLDGHRTRR RGLFPGGRHE LRRNIAVTTS MSCTDFSFHF PMMFNTLVNS
SWGDSVELHA NVTCNNEDSD LLEDNSATTI IPILYPINIL IQDQEDSTLY VSFTPKGPKI
HQVKHMYQVR IQPSIHDHNI PTLEAVVGVP QPPSEGPITH QWSVQMEPPV PCHYEDLERL
PDAAEPCLPG ALFRCPVVFR QEILVQVIGT LELVGEIEAS SMFSLCSSLS ISFNSSKHFH
LYGSNASLAQ VVMKVDVVYE KQMLYLYVLS GIGGLLLLLL IFIVLYKVGF FKRNLKEKME
AGRGVPNGIP AEDSEQLASG QEAGDPGCLK PLHEKDSESG GGKD
//
