ID B4EGQ6_BURCJ Unreviewed; 508 AA.
AC B4EGQ6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN ORFNames=BCAM1151 {ECO:0000313|EMBL:CAR55007.1};
OS Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 /
OS NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=216591 {ECO:0000313|EMBL:CAR55007.1, ECO:0000313|Proteomes:UP000001035};
RN [1] {ECO:0000313|EMBL:CAR55007.1, ECO:0000313|Proteomes:UP000001035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 /
RC CF5610 {ECO:0000313|Proteomes:UP000001035};
RX PubMed=18931103; DOI=10.1128/JB.01230-08;
RA Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D.,
RA Cerdeno-Tarraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S.,
RA Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K.,
RA Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D.,
RA Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R.,
RA Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J.;
RT "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT cystic fibrosis patients.";
RL J. Bacteriol. 191:261-277(2009).
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DR EMBL; AM747721; CAR55007.1; -; Genomic_DNA.
DR RefSeq; WP_006485290.1; NC_011001.1.
DR AlphaFoldDB; B4EGQ6; -.
DR KEGG; bcj:BCAM1151; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_10_4; -.
DR BioCyc; BCEN216591:G1G1V-5150-MONOMER; -.
DR Proteomes; UP000001035; Chromosome 2.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:InterPro.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF3; METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 23..487
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 508 AA; 53853 MW; 3809E8522FC98135 CRC64;
MNAAVPQTTL ALPTAKLLID GAFVDSRSAE WGDIVNPATQ EVIGRVPYAT LDEVDAAIAS
AQRAFQTWKT TPIGARLRIM LKFQDLVRRN LERIAHTLTA EQGKTLPDAQ GDIFRGLEVV
EHACSIGTLQ QGEFAENVAG GVDTYTLRQP IGVCAGITPF NFPGMIPLWM FPMAIVCGNT
FVLKPSEQDP LSTMQLVELA IEAGVPPGVL NVVHGGKTVV DRLCTHPDIK AISFVGSTRV
GTHVYNLGSQ HGKRVQSMMG AKNHAVVLPD AHREQSINAL VGAGFGAAGQ RCMATSVVVL
VGQARDWLPD LVEKAKALKV NAGAEAGTDV GPVVSKAAKA RILSLIDAGV KEGATLLLDG
RDVKVPGYEH GNFVGPTIFS GVTTDMSIYQ EEIFGPVVVV MEAGTLDDAI ALVNRNPMGN
GVGLFTQSGA AARKFQSEID VGQVGINIPI PVPVPYFSFT GSRGSKLGDL GPYGKQVVQF
YTQTKTVTAR WFDDDATAGG VNTTIALR
//
