ID NAAT1_DROGR Reviewed; 636 AA.
AC B4JMC1;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GH24359;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1] {ECO:0000312|EMBL:EDV91882.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV91882.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDV91882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH916371; EDV91882.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001992175.1; XM_001992139.1.
DR AlphaFoldDB; B4JMC1; -.
DR SMR; B4JMC1; -.
DR GlyCosmos; B4JMC1; 1 site, No reported glycans.
DR GeneID; 6566079; -.
DR KEGG; dgr:6566079; -.
DR eggNOG; KOG3660; Eukaryota.
DR InParanoid; B4JMC1; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0015175; F:neutral L-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR CDD; cd10324; SLC6sbd; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..636
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386583"
FT TOPO_DOM 1..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..531
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 547..567
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 636 AA; 71119 MW; FE158DAF70976816 CRC64;
MELKTMPQNG ANNGNPQGNT SNNNNTNDSS NSNSNNNNKT ERTNWSNGLE FLMSCISVSV
GLGNIWRFPF TAYENGGGAF LIPYIIVLFM IGKPMYYLEM IMGQFTSQGT VKIWSICPSF
LGVGYGQAFG TICIISYYSS LLALTLYYLA VSFQADLPWS TCRDTWINCV NSRPAEYIET
MMTNGSSALT RATDTPAKLQ SSSELYFLDV VINEKTDISD GVGNPDWKLT IALFVSWIVI
FLVIMRGVKS SGKAAYFLAL FPYVVLFTLL GRAVTLEGAV DGIIFFLEPQ WGELLNPTVW
KEAVVQCFFS LAVGSGPIIM FSSYNRFDHP IYRDAMIVTT LDTLTSLLGG ITIFAILGNL
AHNLKVENIR DVVRSGTGLA FISYPDAISK FNAVPQLFSA LFFFMLFVLG IGSIVALQST
IVTIICDQFK WKYWKVALVT SICGFLMGLV YVTPGGQWIL TLVDFYGGTY VVFILAIFEL
VGIAWIYGVS NFCDDIEFMS NKRVSLYWRA CWLIFTPIMM IVIFIYSMVT ITPIKYSDIY
FPVAGDVAGW LLFAIGASQF PLWGWWYVHN HRTGSIAKSF VDSLKPSQKW GPADPETRRN
WLLFKSDLAA KRAVQAKSDK MGFFRQKLYN MCGRST
//
