ID B4MCY4_DROVI Unreviewed; 1258 AA.
AC B4MCY4;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN Name=Dvir\GJ15330 {ECO:0000313|EMBL:EDW58056.1};
GN ORFNames=Dvir_GJ15330 {ECO:0000313|EMBL:EDW58056.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW58056.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW58056.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149};
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DR EMBL; CH940660; EDW58056.1; -; Genomic_DNA.
DR RefSeq; XP_002058987.1; XM_002058951.2.
DR AlphaFoldDB; B4MCY4; -.
DR SMR; B4MCY4; -.
DR STRING; 7244.B4MCY4; -.
DR EnsemblMetazoa; FBtr0231255; FBpp0229747; FBgn0202524.
DR GeneID; 6635447; -.
DR KEGG; dvi:6635447; -.
DR eggNOG; KOG0197; Eukaryota.
DR HOGENOM; CLU_008155_2_1_1; -.
DR InParanoid; B4MCY4; -.
DR OMA; FMKLHEN; -.
DR OrthoDB; 1614410at2759; -.
DR PhylomeDB; B4MCY4; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005126; F:cytokine receptor binding; IEA:EnsemblMetazoa.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0001751; P:compound eye photoreceptor cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa.
DR GO; GO:0045317; P:equator specification; IEA:EnsemblMetazoa.
DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0030713; P:follicle cell of egg chamber stalk formation; IEA:EnsemblMetazoa.
DR GO; GO:0007481; P:haltere disc morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0042386; P:hemocyte differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0007442; P:hindgut morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IEA:EnsemblMetazoa.
DR GO; GO:0007478; P:leg disc morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0045475; P:locomotor rhythm; IEA:EnsemblMetazoa.
DR GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
DR GO; GO:0019100; P:male germ-line sex determination; IEA:EnsemblMetazoa.
DR GO; GO:0060031; P:mediolateral intercalation; IEA:EnsemblMetazoa.
DR GO; GO:0016318; P:ommatidial rotation; IEA:EnsemblMetazoa.
DR GO; GO:0007424; P:open tracheal system development; IEA:EnsemblMetazoa.
DR GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IEA:EnsemblMetazoa.
DR GO; GO:0007365; P:periodic partitioning; IEA:EnsemblMetazoa.
DR GO; GO:0031453; P:positive regulation of heterochromatin formation; IEA:EnsemblMetazoa.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:EnsemblMetazoa.
DR GO; GO:0016476; P:regulation of embryonic cell shape; IEA:EnsemblMetazoa.
DR GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0007472; P:wing disc morphogenesis; IEA:EnsemblMetazoa.
DR CDD; cd09921; SH2_Jak_family; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041046; FERM_F2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR45807; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR PANTHER; PTHR45807:SF7; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR Pfam; PF18377; FERM_F2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EDW58056.1};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 35..421
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 587..845
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 938..1199
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 254..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 973
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1258 AA; 145937 MW; 0592BFCB5CFDFFFB CRC64;
MDDSSSGRTS LADSASLATA SLQSGSSSQN IANDGLIHVY NYRRGDYEKF SPSLHCEEIC
TIMCRHMDIL PTAVLLFGIR EQSNGTETSP MTLKVKHKWQ LPGELLNSSV RYCFRMRFRV
PELDRQLPVI DVHCHKYLYH QMRYDMLHEQ IAEIRYPEQR DKVMGLAVMD MVIDREEQLL
LAQAVEKAYK SYLPRSLWRA HRIFVRSKIR STFRRLNSNR PNVDSLKWHY VHQICDLAPT
YLTEQFNATV EYFPNESTTE PPHGNGSIAS STRTSTTTLV TGSNTTLSTT ITGPGNQRND
SGSDTHTLRG SQQTPQPSRH RASQQQQLQP NSIPVYVRLF HHDSPEPGLK VARVTSEATL
KWSLVAVVED IFSLYKESEQ LVRLEIVGFP KGYHMRFETE HEMKSFISYL GIYIRLTVKW
MQDLCPSYKT PSLEELERLY CHGPIGGGYS FMKLHENGDK CGSYIVRQCD REYNTYYIDI
NTRIVARNSD HDRCQTETFK IIRKDKQWKL EHKSDEHIFD QLSELAQFIR TDSPDRIRIP
ASKYDKPPLL LLCLPKNLKT KKTEAELSEA ELQRRNPQIF NAKTDLQWYR DSINDSDDDK
VYTMRGDWMQ QGSFKDVPVT MKMLKYDANF EEFMKLAQTW SLIQSPQFIK LYGLTLSVPY
TMVMEYSKYG PLNKFLQMHR NISMYCLLDV MHGLVRGMHY LEDNKIIHNY IRCSNLYVTK
YDSEKYVLDA KISDPGCPRP YKQSDSPWIP IKYYNNLEGA KQDSSTQLWA FATTIYEIFS
RGQLSLDQLK QRDLIRNRTI DGGILKPLNQ RLCPPEMYNT IMDGWSDDPD KRFSHHDIFT
RLNAIKTRLQ RNYDVPETEM ESFEYSDDHM HCNDDENDFS SEAHASFNGH GLPNGQHHSP
DSDSLTMCNG AVGLSSEFFA NSHDLPLVMQ LYDCKVIYRE KHKIGQGHYG TVYRGELEYH
DKDRPKEQVA IKKLKTVQVT NDFLREIDIM RKLDHPNVVK FKYWAEKSLS IIMEYFEFGS
FIVYLSSRKP SLTNARLLAF ALDIAHGMDY LSGKGLIHRD LAARNILVDR SCVKISDFGL
AQFANADGYY YGISQRDIPI KWYSPEAIET LKFSSYSDVW SYGVTLFEMF SRGEIPNLVP
GQDLPQDQFL NRLRQGERLP KPELCSDFVY NELMRPCWHE TPKSRPTFQQ IIQIITSEIG
DNVGSATGSQ QQLQQQQQQQ QQQQQQQQQQ QQQQLQQQQQ PLNRGNSLED MYKGLTIT
//
