ID B4MWK4_DROWI Unreviewed; 1800 AA.
AC B4MWK4;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Laminin subunit beta-1 {ECO:0008006|Google:ProtNLM};
GN Name=Dwil\GK14820 {ECO:0000313|EMBL:EDW76145.1};
GN ORFNames=Dwil_GK14820 {ECO:0000313|EMBL:EDW76145.1};
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW76145.1, ECO:0000313|Proteomes:UP000007798};
RN [1] {ECO:0000313|EMBL:EDW76145.1, ECO:0000313|Proteomes:UP000007798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; CH963857; EDW76145.1; -; Genomic_DNA.
DR RefSeq; XP_002065159.1; XM_002065123.2.
DR STRING; 7260.B4MWK4; -.
DR EnsemblMetazoa; FBtr0245471; FBpp0243963; FBgn0216825.
DR GeneID; 6642771; -.
DR KEGG; dwi:6642771; -.
DR eggNOG; KOG0994; Eukaryota.
DR HOGENOM; CLU_001560_1_0_1; -.
DR InParanoid; B4MWK4; -.
DR OMA; PCANSHP; -.
DR OrthoDB; 90222at2759; -.
DR PhylomeDB; B4MWK4; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005925; C:focal adhesion; IEA:EnsemblMetazoa.
DR GO; GO:0070831; P:basement membrane assembly; IEA:EnsemblMetazoa.
DR GO; GO:0055013; P:cardiac muscle cell development; IEA:EnsemblMetazoa.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IEA:EnsemblMetazoa.
DR GO; GO:0016477; P:cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0008406; P:gonad development; IEA:EnsemblMetazoa.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:EnsemblMetazoa.
DR CDD; cd00055; EGF_Lam; 13.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR PANTHER; PTHR10574:SF448; WING BLISTER, ISOFORM B; 1.
DR Pfam; PF00053; Laminin_EGF; 13.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 9.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1800
FT /note="Laminin subunit beta-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002818761"
FT DOMAIN 57..294
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 422..481
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 482..532
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 571..795
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 801..848
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 849..894
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 895..944
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1003..1054
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1055..1105
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1106..1153
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1154..1200
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1695..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1273..1338
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1389..1416
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1753..1787
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 34..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1702..1721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 452..461
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 504..513
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 516..530
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 801..813
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 803..820
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 822..831
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 849..861
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 851..868
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 870..879
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 914..923
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1027..1036
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1078..1087
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1106..1118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1108..1125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1127..1136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1154..1166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1156..1173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1175..1184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1800 AA; 199518 MW; B307CC801D07AF1B CRC64;
MLELLRPQRS GLIAIFFVLV VAVLSSQLEA QRLPPQHGRH DRPRNPPRQY VKTHPCERSS
CYPATGNLLI GRENRLTASS TCGLYSPERF CILSHLQDKK CFLCDTREET RTDPYKNHRI
GQIIYKTKPG TNIPTWWQSE NGKENATIQL DLEAEFHFTH LIITFTTFRP AAMYIERSFD
FGATWHVYRY FAYDCEDSFP GVPTALHNIT DVVCTSRYSN VEPSRNGEVI FRVLPPNINV
TNPYADHVQN QLKMTNLRIQ MTKLHKLGDN LLDNRLENEE KYYYGISNMV VRGSCSCYGH
ASQCLPLDDA ITNDFDMVHG RCECTHNTKG LNCESCEDFF NDLPWKPAFG KQTNACKKCE
CNDHAVSCHF DEAVFTASGH VSGGVCDNCM HNTQGQHCEE CMPFFYRDPV EDLRSPYVCK
PCDCDPNGAL DDGICDSVND PENGAIAGAC HCKPNVKGRR CDVCKDGFWN LQTDNPEGCE
SCTCNILGTI DNSGCNMYNG ECTCKRLVTG KDCNQCQPET YGLSESEDGC TMCNCDAGGS
YDNYCDVITG QCRCRPHMTG LNCSLPLQNY FIPDLVVVHE AEVSDICITY GNNGNCSSVP
QAPSPDDTRP PEFTGTGMKR LPENTELTIV VDDIPRSMPY DVVVRYQPTA RGDWEDAYIT
LVRPDEIDPE GECAGLVAAY GTETKIPFSL PDRDRQVVAL HDVCLETGKI YKFKIFFERR
VHNEDNPAAT ILVDSLTLIP RIEVTPIFSG SPIADLRLRD YINNNCNQSL YDMRYAGFAS
PKCKSLENSV SKYIYDGARM CSCNPTGSLS KNCESNGGIC QCKPHVVGRQ CDQCAPGTYG
FGPEGCKACD CNSIGSKDNN CDLLTGQCAC HPNTYGRECN QCQPGYWNFP NCQVCECNGH
AAQCDPVTGQ CIQCQDSTAG YACDTCLDGY YGDPLLGSVI GCRPCRCPDT VASGLAHADG
CSLDTRDNNM LCHCQEGYAG SRCEICADNF YGQPENGGTC SKCECSNNID PYDTGNCDRQ
TGACLKCLYQ TTGDHCELCR DGFFGDALQQ NCQQCECDFL GTNNTLAHCD RHTGQCPCLP
NVQGLRCDQC EVNHWKIASG EGCELCNCDP IGAVQEQCNP YTGQCECKQG FGGRACNQCQ
AHYWGNPNEK CQPCECDPFG SADYQCDRET GKCQCHEGIG GYKCNECARG YLGQFPHCAP
CGECFNNWDL ILNALEDATQ ATIQRAREIK QVGATGAYTA EFSELDKKLQ HIKTLLQNTT
VSLVDIDRLD GEANALKQQL IASHQRLSET ENDLDEIYNS LSLSAVELEG LQNHSRQVQE
LSKELKENGI ELQESNIEGA LNLTRHAYER VNNLSALKDE ARELASNTDR NCKRVETLSN
KIKGESDAIA ANDQTIAEYR NELSSLTSQI PELNNQVCGK PGDPCDNLCG GAGCGKCGGF
LSCEHGARAH SEEALKVAKD TEEAIVKKKD QADQTIRALT QAKLNASQAY EKAKQGFELA
ERYLNQTDAN IKTAAKLINA VRDFQENTTA SPAESKQLAQ DTLALDLTLD PKEIESLGVK
INDAVASLKN VESIIYRTRP DLDRVNQLQT IANQTKETAN KILETANSVV ENLSAADDSQ
SKAQEAIQQA NSNIELAAKD LEKIDEETTA AESPANVTAK QVDDLAKKVQ RLQKNILKNE
LDAKEITKEA NRVKAEAQRA HGEANNLQSS TSATNQTLTD RAIRSEKARE RAKLLLQRAS
KLTVDTNEKW KELNQLQDNY EERNLKLAKL QENIQPLTDE VTQYLRRIQE DAERYKVCTL
//
