ID B4NID8_DROWI Unreviewed; 1425 AA.
AC B4NID8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Uncharacterized protein, isoform A {ECO:0000313|EMBL:EDW83720.1};
DE SubName: Full=Uncharacterized protein, isoform B {ECO:0000313|EMBL:KRF99863.1};
GN Name=Dwil\GK13528 {ECO:0000313|EMBL:EDW83720.1};
GN ORFNames=Dwil_GK13528 {ECO:0000313|EMBL:EDW83720.1};
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW83720.1, ECO:0000313|Proteomes:UP000007798};
RN [1] {ECO:0000313|EMBL:KRF99863.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14030-0811.24 {ECO:0000313|EMBL:KRF99863.1};
RA Qian G., Yu M.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDW83720.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14030-0811.24 {ECO:0000313|EMBL:EDW83720.1};
RA Remington K., Strausberg R., Sutton G., Walenz B., Johnson J.,
RA Utterback T., Venter J.C.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EDW83720.1, ECO:0000313|Proteomes:UP000007798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSC#14030-0811.24 {ECO:0000313|EMBL:EDW83720.1}, and Tucson
RC 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [4] {ECO:0000313|EMBL:EDW83720.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14030-0811.24 {ECO:0000313|EMBL:EDW83720.1};
RX PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
RA Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
RT "Assembly reconciliation.";
RL Bioinformatics 24:42-45(2008).
RN [5] {ECO:0000313|EMBL:EDW83720.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14030-0811.24 {ECO:0000313|EMBL:EDW83720.1};
RG FlyBase;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH964272; EDW83720.1; -; Genomic_DNA.
DR EMBL; CH964272; KRF99863.1; -; Genomic_DNA.
DR RefSeq; XP_002072734.1; XM_002072698.2.
DR RefSeq; XP_015032342.1; XM_015176856.1.
DR SMR; B4NID8; -.
DR STRING; 7260.B4NID8; -.
DR EnsemblMetazoa; FBtr0244179; FBpp0242671; FBgn0215536.
DR EnsemblMetazoa; FBtr0420905; FBpp0379015; FBgn0215536.
DR eggNOG; KOG3513; Eukaryota.
DR HOGENOM; CLU_005756_0_0_1; -.
DR InParanoid; B4NID8; -.
DR OMA; KICKAYT; -.
DR OrthoDB; 3073820at2759; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005918; C:septate junction; IEA:EnsemblMetazoa.
DR GO; GO:0008366; P:axon ensheathment; IEA:EnsemblMetazoa.
DR GO; GO:0061343; P:cell adhesion involved in heart morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0060857; P:establishment of glial blood-brain barrier; IEA:EnsemblMetazoa.
DR GO; GO:0021682; P:nerve maturation; IEA:EnsemblMetazoa.
DR GO; GO:0019991; P:septate junction assembly; IEA:EnsemblMetazoa.
DR CDD; cd00063; FN3; 4.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 4.
DR Pfam; PF05473; UL45; 1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1425
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015087310"
FT TRANSMEM 1405..1423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 394..495
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 518..593
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 608..688
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 693..785
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 788..875
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 880..965
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 978..1080
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1085..1183
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1188..1286
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1291..1389
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 36..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1425 AA; 162516 MW; 4BAAA31D971AB6FD CRC64;
MFQIVGGLSR YFTYFLLVEL CFLAVAQLPG SEYMPQQNLD QPQSQPQTYQ PTYNKDYSPR
YNPLYTGQQQ PQPNSNIDAN QYDNPLLDNN PNNYNPNNGY FDGNRPLIGG GGNVNVGGPG
QNLGGIGLGP QYDPFNRNSL NSGGGVGGGL GGGAGGLGYR DMFSDEENFC PEHWVSFRQT
CYRFIRSPKR NWAEAKKICK AYNADLINVD NVEKHSFILR NLIVQNQRQN RFFISARQTG
PQNWVNDDNT QLIHIEDSFA FDEQLPLENE DLHDNRFLVQ NDLNLNRNPN NPNQFYNVLP
GNVNQRNQNN LRGYIGANQP YGDNGYIRDR VVYAFSKKRD KWVFMPAYEI ELNLFICESR
SLYTPDNVNI KLDDKRPYHY GLDIRDLERI PRGPYFVKQP NDTTFDVNKN RLINDVSLSC
LAGGFPTPTY QWYREVYVND TLEYRRIDPL VQDRYTISGG NLIIYEPKQA LDQGAYHCVA
ENKFGRVRSE SAHLNFGFIM EFNLKRSSET SEMNWGKSIF CDPPQHYPAV RYYWARDYFP
NFVEEDQRVF VSHDGALYFS FIETVDRANY SCTVQTLVSD TGRNGPFFSL RVTPNSNYQA
LIFANTFPKV FPEAPVAGED IRLECMAFGY PIPSYNWTRQ GQNLQRNAYT TNYGRVLIIQ
NATTNDNGEY TCTITNLRKT LVKSIYINIQ MRPEFTIPLK DMIKDYNSDV TFICEAFAIP
DANYTWYKNA ERLDPLTINR DRYVIQDNVL TIKFLEKDKD EGMYQCGAQN QLKTSFSSSQ
LRVLSMKPSF KKHPLEAEIY AVFNGNTTIV CDPEAAPRPK FQWKKDGQLL GSGGHRRILP
SGTLIISPTS RDDEGMYTCI ASNQAGTDES HARVIVLQEI RFLQTPPQRI VSKEHDLIYL
HCEAIYDELL DIAYVWKHNG EILKNDHDGT TRIIVDWNSL TVHNTTMADA GDYECVVQSA
VNEISAKTVV VIEGAPGAPG GVQVNQIAKT KAIIEWVDGA NNGRPIRYYN ILGRTNWNRT
WTNVSTHVQA KEIDRYTMRQ QAEVMNLTPW SSYEFSVTAV NDLGIGTPSA PSPIYSTYED
KPYVPPRNVG GGGGKIGDLT ITWDPLLPQE QHSHGIHYKV FWKLKGAKEW ATDIIMKQEN
VGVAVVNIPR ENYYTQYDVK VQAINNVGKG PESEMVTIYS AEDMPQVSPQ KPFALPFNST
CFNVTWQPID MSREHIRGKL IGHRLKYWKT THQEEDAVYY LSRTTRNWAL IVGLQPDTYY
FVKVMAYNAA GEGPESERFE ERTYRKAPQK PPSSVHVYGI NPSTVRVVWR YVSPSQDEEP
IEGYKVRIWE TDQNMITANN TIVPIGQKLE SYINTLTPGK SYNMRVLAFS NGGDGRMSSP
TLRFQMGKTT RNSATLGGGH YTSNVNSALI MSLLLFLTHF FYIDY
//
