ID B4NK82_DROWI Unreviewed; 2778 AA.
AC B4NK82;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=Dwil\GK12780 {ECO:0000313|EMBL:EDW85124.2};
GN ORFNames=Dwil_GK12780 {ECO:0000313|EMBL:EDW85124.2};
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW85124.2, ECO:0000313|Proteomes:UP000007798};
RN [1] {ECO:0000313|EMBL:EDW85124.2, ECO:0000313|Proteomes:UP000007798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CH964272; EDW85124.2; -; Genomic_DNA.
DR RefSeq; XP_002074138.2; XM_002074102.2.
DR STRING; 7260.B4NK82; -.
DR EnsemblMetazoa; FBtr0420600; FBpp0378716; FBgn0214789.
DR eggNOG; KOG0892; Eukaryota.
DR HOGENOM; CLU_227091_0_0_1; -.
DR InParanoid; B4NK82; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035173; F:histone kinase activity; IEA:EnsemblMetazoa.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000706; P:meiotic DNA double-strand break processing; IEA:EnsemblMetazoa.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:EnsemblMetazoa.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:EnsemblMetazoa.
DR GO; GO:0034351; P:negative regulation of glial cell apoptotic process; IEA:EnsemblMetazoa.
DR GO; GO:0045824; P:negative regulation of innate immune response; IEA:EnsemblMetazoa.
DR GO; GO:0030717; P:oocyte karyosome formation; IEA:EnsemblMetazoa.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0043687; P:post-translational protein modification; IEA:EnsemblMetazoa.
DR GO; GO:0006468; P:protein phosphorylation; IEA:EnsemblMetazoa.
DR GO; GO:0031509; P:subtelomeric heterochromatin formation; IEA:EnsemblMetazoa.
DR GO; GO:0000723; P:telomere maintenance; IEA:EnsemblMetazoa.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1723..2325
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2430..2745
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2746..2778
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2778 AA; 320327 MW; E9E27DDF2593A298 CRC64;
MSGLLNEIHR IATDIRSEKA PARNKAIEQF DQKLNSSKEA LNALFQDKKT DLTWTSVFES
AKEAIFKHAG NLQDAREKTF KSLADKNYLY GNVLGKIINY NLEVGTTTTG HFLAKTTVFN
AFEEFIKTRI VVKHFGERIL NILDRGIYLS PSYVRELRVN EYSRILSYLF ELNIENDEFL
RSKLLKCITK TLQLAKDRVQ LHNDLVEYLP GLAYFAQTAI NSERKVEIVR LYSIFVSELS
VNYHHRLCLH IQEILPKLCE FHNDDVFRDD TRNIFFKSVI HSLNSMYPKL NLCDFTTFQV
PINENWAQTM CKLKSIVYME IKANSLQRYK TAQLNNDKFS ESFIKMSAMI MFIVLWHIEV
KGAAPDAAGD VPKKIHRQND QMETMFKLID KKEATFSDIW FAIFAELLQL SDGILNLANY
QQALTITLDV LQMYGNARNL KNIRLCIVSL LKKERNWLDT QSLPPNTFGE LWTQITTNLI
SDTTANGDEI REKQIILQML IRHGKLDPKV VRNLLQTITS NEVLKRNECI ATIREIFIRS
RLCGLDKASS VEFKPIVEWA YASGERSTAT QAIHNIAAID AKLLADTFSI SIINFLDEQQ
LQQLCNQNAD AIGNDSESDH KMLSYKYNRK LVCLDRDFLG HFKAKNNLTT ETNGAAKNCL
YQNNYEFLMR TLNFQNANDN QPRSMLKNLN SLHKLVCTME RLLNYKVFDD ANFTTCPLIK
RIGLFLSHIE FQYKANSPVA ISDADLRDIL RLQIAVLDVF QSNHVLLNYL ENQPIEMLIE
FVGVTLKQNS IKRERAENHD FDTITGLCLQ ILSGLCASNS HRDEAFDHLA KVTMRWQPKD
ILIVTKMFCS CNSLSDASCI WLVDKLKPVF QHHYQDLDII SEVVDYLPKI FYFVYNMEHQ
LDDMFMALNS LLKIALKKSY TSQLTAKILY CVGQIAQRCR NIYAMENFGV ICKSAAKFIT
MPTLDVRYAT LCTLTILLNT ECVAGDAIND AQDHWTFCDE LYTSIDFKKF SFDDEDMMQN
SHSAMFQILL AIFAFSSFHQ ETALKQLLHF CALRKLNETD FCALNSLVPC HNRTMRDLLR
TYANMMLHKW CSKGWPVSKF PFFLCYDTKT DFRKANGKSI MAYTILYAKP DDIQRYRKII
KEEEALPLIA AYVMPECSKC EEFQTPAYQQ HYRNLVNNLN ELNAKDIECN ALTIYNLISL
LFDAEEMVKL FGDSVPWINS REWYNLTTDS LFKSLNWHIN QECNSLNNNI EDLGVKVMAT
LQTKHSIVLI DLFGILKTNC YTAVFTSQTL HSLFHYCVIA NAVYDSARML EHQTTKDNSH
HMQSSYFVRD IWYFLVRFLK HTQCQIATLD FLKMLLEKPK FQTERFSSHM NEIAKLLVNF
IVQSKQKPVK DKAVVILEHV LEAYKTQINT QPLLEESTEC EFLKSLREQF NESLPKTDKG
NVTEYIQSFL TNTSVERLND LREYISEHKD KLQSNESLLF DLINRLLRLA RDCHNKNTSL
DALKCLAEIG PMHLRHVSYY FQTEFDTLQE SDKLPMEQFL TIICESFEKY LFEFDPKTQE
ALITVARNVV NSKAGIKIKS FYSNLQIFVG KSKDVNFLNK PISTIDWLAA LEATKHLSYE
SWICAFMSRV FKECGWQGFD NLAAESYSFA EICLQPFVKL LLDNKEQHLD SLCQMLDHFF
QSFVSQQSNH VIFQEKRAIK KLLNICECIR TTNNWCIPIE LSNVVLASNH CQAYFLSVLY
LELWACSNSE KSTAEILANE TFQACAKKSY ESIGCLDAIP GFLNPLSSRV DFLNHDNNLC
GILLESDNSH RQLCVDIMKS NGMWSWAHLR QHQNQGTERD YEIFWRLGQW NELVDHQNSL
GDIGRASVNL EQEFKKYHYL ALKSINNREE ENSRSAIGSA YQCVVDILQD ISMECLQIVY
KYMTWLCTLT QAEDFCQIQF ATQLSTSNLG QLFNKWQTEL DLKYGNFACK EYIISHQIAL
FKMAGTRASR RMQGFYKENP IDMYLLKGIA ECKSSGKLNL ASKYIAMLRD LTGINKSSKI
SMLLEDADVN IRTGNHRIAK AILNHMETNK EFNYCLQRVP ALRMQGEFLL DSNAESLSSV
LHSKFNGSLK LLNDFVEHKD TLQEKFPQIF KWQEFAAFEN ENRKAAYASI AKYADREYQQ
LHDYRQSQDY NTLAEIIAQN RQVADKVTTR EDRDHRIIAV HMKRFANLDE KELQRIDDNL
TEHLCTAVQN YMAYCKLDSG LSSAAIYRII SLWFTNARNM VLLTKLESEI QTVPSYKFIC
AVNQLIGRLN SKNRELLKIL VDLLVRCGQE HPHHTFYQLY PLVFAKLDGV NSNTEREAIA
GKIIAKIREN NPSVLETSKQ LETMFPVLIA YANHDSESEN NKPTAKSIAE RNKLRDYILR
LKKLNAVHCP TLELPVSPSK EYNITSIVKW TNEFSDCGGL NAPTKVICLC SDGQLRSQLI
KGKDDLRQDA VMQQVFGIVN ELLQQDSEFI ERNLHVRTYK VTPLSMRSGI LEWCSNSIPV
GRYLVGEGKS GAHMKYRPND WNNNKCRTLS HTHLRAPKDK RFEIYKQICE HVKPVFHYFL
LEKFPIPGIW FERRLAYTNS VATTSIVGYI LGLGDRHTQN ILIDEQTAEV IHIDFGIAFE
QGKIQATPET VPFRLTRDFV APMGVCGTNG VFTKSCEATM QILRRYKSVL ITILEVLLYD
PLFIWGVLSK KKTNQPTGEE SVNLVAQRAL LLVQNKLEGR ESGTLGNSNV EAQVERLINE
ATLPSNLCML FPGWDPYL
//
