ID B4PHX3_DROYA Unreviewed; 1265 AA.
AC B4PHX3;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN Name=Dyak\GE21986 {ECO:0000313|EMBL:EDW94448.1};
GN ORFNames=Dyak_GE21986 {ECO:0000313|EMBL:EDW94448.1};
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245 {ECO:0000313|EMBL:EDW94448.1, ECO:0000313|Proteomes:UP000002282};
RN [1] {ECO:0000313|EMBL:EDW94448.1, ECO:0000313|Proteomes:UP000002282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01
RC {ECO:0000313|Proteomes:UP000002282};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000313|EMBL:EDW94448.1, ECO:0000313|Proteomes:UP000002282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01
RC {ECO:0000313|Proteomes:UP000002282};
RX PubMed=17550304; DOI=10.1371/journal.pbio.0050152;
RA Ranz J.M., Maurin D., Chan Y.S., von Grotthuss M., Hillier L.W., Roote J.,
RA Ashburner M., Bergman C.M.;
RT "Principles of genome evolution in the Drosophila melanogaster species
RT group.";
RL PLoS Biol. 5:E152-E152(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
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DR EMBL; CM000159; EDW94448.1; -; Genomic_DNA.
DR RefSeq; XP_002094736.1; XM_002094700.2.
DR AlphaFoldDB; B4PHX3; -.
DR SMR; B4PHX3; -.
DR EnsemblMetazoa; FBtr0268504; FBpp0266996; FBgn0239219.
DR GeneID; 6534050; -.
DR KEGG; dya:Dyak_GE21986; -.
DR eggNOG; KOG0971; Eukaryota.
DR HOGENOM; CLU_002523_0_1_1; -.
DR OMA; LFEMEPV; -.
DR OrthoDB; 9423at2759; -.
DR PhylomeDB; B4PHX3; -.
DR Proteomes; UP000002282; Chromosome 3L.
DR GO; GO:0005818; C:aster; IEA:EnsemblMetazoa.
DR GO; GO:1904115; C:axon cytoplasm; IEA:EnsemblMetazoa.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:EnsemblMetazoa.
DR GO; GO:0005828; C:kinetochore microtubule; IEA:EnsemblMetazoa.
DR GO; GO:0030496; C:midbody; IEA:EnsemblMetazoa.
DR GO; GO:0061803; C:posterior cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0031616; C:spindle pole centrosome; IEA:EnsemblMetazoa.
DR GO; GO:0061176; C:type Ib terminal bouton; IEA:EnsemblMetazoa.
DR GO; GO:0070840; F:dynein complex binding; IEA:EnsemblMetazoa.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:EnsemblMetazoa.
DR GO; GO:0008017; F:microtubule binding; IEA:EnsemblMetazoa.
DR GO; GO:0048675; P:axon extension; IEA:EnsemblMetazoa.
DR GO; GO:0019896; P:axonal transport of mitochondrion; IEA:EnsemblMetazoa.
DR GO; GO:0001709; P:cell fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0007349; P:cellularization; IEA:EnsemblMetazoa.
DR GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR GO; GO:0051299; P:centrosome separation; IEA:EnsemblMetazoa.
DR GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:EnsemblMetazoa.
DR GO; GO:0061670; P:evoked neurotransmitter secretion; IEA:EnsemblMetazoa.
DR GO; GO:0006886; P:intracellular protein transport; IEA:EnsemblMetazoa.
DR GO; GO:0051383; P:kinetochore organization; IEA:EnsemblMetazoa.
DR GO; GO:0035149; P:lumen formation, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0035011; P:melanotic encapsulation of foreign target; IEA:EnsemblMetazoa.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; IEA:EnsemblMetazoa.
DR GO; GO:0051028; P:mRNA transport; IEA:EnsemblMetazoa.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblMetazoa.
DR GO; GO:1990049; P:retrograde neuronal dense core vesicle transport; IEA:EnsemblMetazoa.
DR GO; GO:0048491; P:retrograde synaptic vesicle transport; IEA:EnsemblMetazoa.
DR GO; GO:0042052; P:rhabdomere development; IEA:EnsemblMetazoa.
DR GO; GO:0016330; P:second mitotic wave involved in compound eye morphogenesis; IEA:EnsemblMetazoa.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Dynein {ECO:0000256|ARBA:ARBA00023017}.
FT DOMAIN 27..69
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 81..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 213..567
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 969..1077
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 88..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1265 AA; 141160 MW; 0FCE108F517304DC CRC64;
MSEKNLKVGA RVELTGKDLL GTVAYVGMTS FAVGKWVGVV LDEPKGKNSG SIKGQQYFQC
DENCGMFVRP TQLRLLEAAP GSRRSIEDVS GATPTAAQPT KARLSSSRTS LSSSRQSLLG
SRTQLTTSLS ERTASSSSIG PRKSLAPQSS KDKESSSTSL AEGAPAPSGG NGAASHASSK
RASFVETGFL EILKPQFTPS QPLRSPSFTM PSNSGAEDKI ALLEAQKTSA ELQAQLADLT
EKLETLKQRR NEDKERLREF DKMKIQFEQL QEFRTKIMAA QASLQKELQR AKQEAKDAIE
AKEQHAQEMA DLADNVEMIT LDKEMAEEKA DTLQLELESS KERIEELQVD LELLRSEMQN
KAESAIGNIS GGGDSPGLST YEFKQLEQQN IRLKETLVRL RDLSAHDKHD IQKLSKELDM
KRSEVAELER TKEKLSAKID ELEAIVADLQ EQVDAALGAE EMVEQLAEKK MELEDKVKLL
EEEIAQLEAL EEVHEQLVES NHELELDLRE ELDLANGAKK EVLRERDAAI ETIYDRDQTI
IKFRELVQKL NDQLTDLRDR NSGNEKESLQ DPSLKMVTET IDYKQMFAES KAYTRAIDVQ
LRQIELSQAN EHVQMLTAFM PESFMSRGGD HDSILVILLI SRIVFKCGIV VSQTRERFPP
VDAITREAVT QGHAVQQYAF KCRLLHYVHS LQCALHQILY GLNSCQPDTL LRAGSSLPEM
VAQEKIVDGI IELLKSNQLD ENSTTDNIEK CVAFFNAMNS VLLAGEQLLN EIQMIRDCVA
SLGAACESIL SDTAIAKVII QEAGATSDSV LLIQFLNENM ESVRQQVKLI KRRLPSDQHV
IKSGLSQHKV EAMRGLAQNI SRIMSTMHQA TKQSLAAIVS TIESDNAAEH TLPQEKYWAL
LTASCERIYE QDDRGPTQNF KTLLAQANSD LQQIAQHLLD KEYEIISAAN NAGGQQKSGA
HSTPITQRAQ LIKKQLEQKN VLAATLENRE ADVKQLKLAA KMKQNELSEM QIRKDLAEKK
LSVLQNEYEH AVDKWKQQYE ETRLQLQQKE KEFEETMDHL QSDIDALESE KSDLRDKLKL
NTSTGKVQSG SESHSPHNLS LTGTTSTAPG NSNVSYSAPA GTAPVVAEEV ELLKNAFNQE
RNERLRLQAQ DMRAKLSQFE PLYVPQPQDQ RITALESELT RMKHAWVLSL LQVRSQDSVN
AGTRIDAVAL QRRNQPVPLK GEISSKASQL ASDILTEYLQ RKPHRAAHGQ FASFPTVDVK
RVLQI
//
