ID B4Q4N6_DROSI Unreviewed; 1507 AA.
AC B4Q4N6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=GD23411 {ECO:0000313|EMBL:EDX03963.1};
GN Name=Dsim\GD23411 {ECO:0000313|EMBL:EDX03963.1};
GN ORFNames=Dsim_GD23411 {ECO:0000313|EMBL:EDX03963.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:EDX03963.1, ECO:0000313|Proteomes:UP000000304};
RN [1] {ECO:0000313|EMBL:EDX03963.1, ECO:0000313|Proteomes:UP000000304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mosaic {ECO:0000313|Proteomes:UP000000304};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CM000361; EDX03963.1; -; Genomic_DNA.
DR STRING; 7240.B4Q4N6; -.
DR HOGENOM; CLU_004145_0_0_1; -.
DR OMA; QIPKVFV; -.
DR PhylomeDB; B4Q4N6; -.
DR Proteomes; UP000000304; Chromosome 2l.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:EnsemblMetazoa.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:EnsemblMetazoa.
DR GO; GO:0006979; P:response to oxidative stress; IEA:EnsemblMetazoa.
DR CDD; cd13150; DAXX_histone_binding; 1.
DR Gene3D; 1.20.58.2170; -; 1.
DR Gene3D; 1.10.8.810; Daxx helical bundle domain; 1.
DR InterPro; IPR046378; DAXX_histone-bd.
DR InterPro; IPR046426; DAXX_histone-bd_sf.
DR InterPro; IPR038298; Daxx_N_sf.
DR PANTHER; PTHR12766:SF12; DAXX-LIKE PROTEIN; 1.
DR PANTHER; PTHR12766; DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX; 1.
DR Pfam; PF20920; DAXX_hist_bd; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000304}.
FT DOMAIN 1224..1304
FT /note="Daxx histone-binding"
FT /evidence="ECO:0000259|Pfam:PF20920"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1302..1330
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1403
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1507 AA; 167122 MW; 8C238568F5E76558 CRC64;
MSASVICVDL SSESDEESPA KRRRLEDPLR VLPPSGRKSL PAKLLNIPKA SLGSAMIVPI
AETGPARETP VIVDPLRSMH IPSGITVTKH QKNVLATNGN LTISLAESNN NNNNNNNNTT
SFNNNVTPKQ INVGTGQKVA WSVSSKAPSP NAVITTVPSH QPVKQNTGIG VQIQQSQQPL
GGPMPTRPKT LGGQLLTQQK PPVGSLQQQN TGIGVQIQQI PKVFVGQQPQ KEYLSKLQQE
QQKILLGHLQ QPQQKTFLGQ LRQEQQKMLG QLQQQQQKKI LGQSQQQKEP LGQLQPQQKP
PQQLNNSLVH LQQQQQHKTS GGQLQQQQQN QPQQKNSMVH VKHQPQQQQK KTSLGQLQQQ
PQQQQKASVG QLQQQQKTSS GQLQQQQKTS VGQLQQQPQQ QQKTSAGQLQ QQQQQKISVG
QLQPQQQQKS SAGQLQQQQK ISAGQLQPQQ QQKISAGQLQ PQQQQKSSAG PLQQQHKISA
GQLQQQQKIS AGQLQQQPQQ QLSSSAGQQQ KLQKASLGQQ SAAQKQGAAP GQQQKLPVGQ
SQPQKRTSAG LLQQQQVPQK KIVMQPQLPK TSVVLPRPQQ LPNPLLVAQQ QSPKTQMAIQ
LLNSVMGPQF PPQQPLLPVV NQITHKSMTI QRLPMLQTTP TVQKILPKQL APQQTPPPAH
ILQKQTMPNA AMQNPPFAHR PPIVRPMTVA KITPVPTNNN VCIPMKPQMA RAVSPPRDAT
MTAARTLPFK RSQRKASAAP MTSTHVQGFT ASATPPQRLL ATPPHCAAAL NEPLLLNLPP
TTSITPQLTP TTTPPPAGPS AAVQQQQLAK AAAIKLNSLP GASISPVNRA QTASAKRIQP
ITVLKKSDEE WRKHLEQQQQ KKHVQLQSSS MTTIVLVESP PTTPPTDKPE PEPERGPMTV
EKSSNQPMPT DKQSSAIKRP AVMISRKKSG SVVTEIVDLD NIPDIPAQKR RKECFPPIKN
ATKAAPSVNA PFTTEYAALL RLCREVDKSA DMERLVKGEL TQYYYSAPES FVMSCGFRNL
VTTAMAMIQN ESYLVYVHLK YVLDELASRR LTKIFPTVRA IPPASHFPLP PTSFTPKQPA
MLNAPEQQTG MAGREQDDEN EEVTLVNVQT ISPEDRRRNE RIRHFYRTLH AITKRIKMLE
EAEVDLNDED SSYLQLERFK KRACQIYEKI CDLKGESKSV RRQLKKPIHF KDSDYPHFNN
SLSAFVNRMQ DFPDYHDVLQ ILEQCNKEKE LGLAKYEMKR IAYDAFNKVG RMLQSRRKND
LYETVTHYTA NGKDPASSDP ELLAKLKENN KKQTKISDIL EKYALEQDLN AEERQEARLK
EKKLKQVKAD EEAAKLAALA EDDDKPCTSA QAAAKAAALA ALKRGPAARG NVIRKKRPAN
GRILKIYDDE DDSEEESDSE DDDVEEFVNN FQANSDVSDA DSEVEAVTSP KRDALPLAEE
EDVIDITRDE TGKKNDEATP NGRLKIMSVS SLNANFVHGQ DLYRKPNPMP SAKPVIADQI
IISDEES
//
