ID B4R7H2_DROSI Unreviewed; 2222 AA.
AC B4R7H2;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=GD16523 {ECO:0000313|EMBL:EDX16783.1};
GN Name=Dsim\GD16523 {ECO:0000313|EMBL:EDX16783.1};
GN ORFNames=Dsim_GD16523 {ECO:0000313|EMBL:EDX16783.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:EDX16783.1, ECO:0000313|Proteomes:UP000000304};
RN [1] {ECO:0000313|EMBL:EDX16783.1, ECO:0000313|Proteomes:UP000000304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mosaic {ECO:0000313|Proteomes:UP000000304};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CM000366; EDX16783.1; -; Genomic_DNA.
DR STRING; 7240.B4R7H2; -.
DR HOGENOM; CLU_001875_1_0_1; -.
DR PhylomeDB; B4R7H2; -.
DR Proteomes; UP000000304; Chromosome x.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 13.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF49; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 13.
DR Pfam; PF07679; I-set; 5.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 13.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 13.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000304};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2000..2022
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..111
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 259..353
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 357..443
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 453..539
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 544..634
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 641..751
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 756..853
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 858..965
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 969..1063
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1067..1162
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1167..1268
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1273..1370
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1374..1467
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1472..1568
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1573..1675
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1680..1783
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1787..1881
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1883..1982
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 2066..2163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2066..2084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2113..2128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2129..2144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2222 AA; 246089 MW; 732AEC1A05DADFD9 CRC64;
MLKSAASSLR RRRPKTTITA TTAIEMPSQP QLASLLAVLV LLCYCDSCFF CYADANLQQQ
NSIVQQQQLQ APRFTTHPSS SGSIVSEGST KILQCHALGY PQPTYRWLKD GVPVGDFSSS
QFYRFHXXXX XXXXXXXXXX XXXXXXLWGG GGSESYMGIF ENTTEGRLTV VSGHPAIFDM
PPIESVPVPS VMWQSEDGPL NYDIKYAFTH ANQLIILSAD ENDRKGYRAK AINTQLGKEE
SSAFVHLNVS GDPYIEVAPE IIVRPQDVKV KVGTGVVELQ CIANARPLHE LETLWLKDGL
AVETAGVRHT LNDPWNRTLA LLQANSSHSG EYTCQVRLRS GGYPAVSASA RLQILEPPLF
FTPMRAETFG EFGGQVQLTC DVVGEPTPQV KWFRNAESVD AHIESGRYTL NTDNTLVIKK
LILDDAAMFQ CLAINEAGEN SASTWLRVKT SAPIMELPPQ NVTALDGKDA TISCRAVGSP
NPNITWIYNE TQLVDISSRV QILESGDLLI SNIRSVDAGL YICVRANEAG SVKGEAYLSV
LVRTQIIQPP VDTTVLLGLT ATLQCKVSSD PSVPYNIDWY REGQSSTPIS NSQRIGVQAD
GQLEIQAVRA SDVGSYACVV TSPGGNETRA ARLSVIELPF PPSNVKVERL PEPQQRSINV
SWTPGFDGNS PISKFIIQRR EVSELEKFVG PVPDPLLNWI TELSNVSADQ RWILLENLKA
ATVYQFRVSA VNRVGEGSPS EPSNVVELPQ EAPSGPPVGF VGSARSMSEI ITQWQPPLEE
HRNGQILGYI LRYRLFGYNN VPWSYQNITN EEQRNFLIQE LITWKDYIVQ IAAYNNMGVG
VYTEGSKIKT KEGVPEAPPT NVKVEAINST AARCRWTPPN PQQINGINQG YKIQAWQRRL
IDGEWRDIER RMKTVPPSLI DPLAEQTAIL GGLEKFTEYN ISVLCFTDPG DGVASIQVAV
MTMDDVPDEV TGLHFDDVSD RSVKVLWAPP RASNGILTGY TVRYQVKDRP DTLKSFNLTA
DDTELTVNQL QATTHYWFEI FAWTRVGSGI PKTATIQSGV EPVLPHAPTA LALSNIEAFS
VVLQFTPGFD GNSSITKWKV EGQTARNMTW FTICEINDPD AETLTVTGLV PFTQYRLRLS
ASNVVGSSKP SEATKDFQTI QARPKHPPFN VTVRAMSAQQ LRVRWIPLQQ TEWYGNPRGY
NISYKQLVKT PGTIKYVPRS VVIEDHTANS HVLDSLEEWT LYEVKMNACN DVGCSKESDT
AVERTREAVP SYGPLDVQAN ATSSTTVVVQ WGEVPRQHRN GQIDGYKVFY AAADRGQQVL
HKTIPNNATF TTTLTELKKY VVYHVQVLAY TRLGNGALST PPIRVQTFED TPGVPSNVSF
PDVSLTMARI IWDVPVDPNG KILAYQVTYT LNGSAMLNYS REFPPSDRTF RATELLPGKY
YSFSCTAQTR LGWGKIATAL VYTTNNRERP QAPSVPQISR SQIQAHQITF SWTPGRDGFA
PLRYYTVEMR ENEGRWQPLP ERVDPSLSSF TAVGLRPYMT YQFRIQATND LGPSAFSRES
VIVRTLPAAP AVGVGGLKVV PITTTSVRVQ WSALETALWN GDASTGGYRI LYQQLSDFPT
ALQSTPKTDV HGINENSVVL SDLQQDRNYE IVVLPFNSQG PGPATPPAAV YVGEAVPTGE
PRAVDAAPIS STEVRLLWKP PKQSMQNGDI LGYKIYYLVT YSPQALEPGR KWEEEIEVVS
ATATSHSLVF LDKFTEYRIQ LLAFNPAGDG PRSAPITVKT LPGVPSAPLH LRFSDITMQS
LEVTWDPPKF LNGEILGYLV TYETTEENEK FSKQVKQKVS NTTLRVQNLE EEVTYTFTVR
AQTSVDYGPG ISENVTTGPQ DGSPVAPRDL ILTKTLSSVE MHWINGPSGR GPILGYLIEA
KKRDDSRWTK IEQTRKGMMQ DFTVSYHILM PSTAYTFRVI AYNRYGISFP VYSKDSILTP
SKLHLEYGYL QHKPFYRQTW FMVSLAATSI VIIVMVIAVL CVKSKSYKYK QEAQKTLEES
MAMSIDERQE LALELYRSRH GVGTGTLNSV GTLRSGTLGT LGRKSTSRPP PGVHLGKSPP
RPSPASVAYH SDEESLKCYD ENPDDSSVTE KPSEVSSSEA SQHSESENES VRSDPHSFVN
HYANVNDSLR QSWKKTKPVR NYSSYTDSEP EGSAVMSLNG GQIIVNNMAR SRAPLPGFSS
FV
//
