ID B4RN19_NEIG2 Unreviewed; 718 AA.
AC B4RN19;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Guanosine-3',5'-bis(Diphosphate) 3'-pyrophophohydrolase {ECO:0000313|EMBL:ACF30186.1};
GN OrderedLocusNames=NGK_1529 {ECO:0000313|EMBL:ACF30186.1};
OS Neisseria gonorrhoeae (strain NCCP11945).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=521006 {ECO:0000313|EMBL:ACF30186.1, ECO:0000313|Proteomes:UP000002564};
RN [1] {ECO:0000313|EMBL:ACF30186.1, ECO:0000313|Proteomes:UP000002564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCCP11945 {ECO:0000313|EMBL:ACF30186.1,
RC ECO:0000313|Proteomes:UP000002564};
RX PubMed=18586945; DOI=10.1128/JB.00566-08;
RA Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.;
RT "Complete genome sequence of Neisseria gonorrhoeae NCCP11945.";
RL J. Bacteriol. 190:6035-6036(2008).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; CP001050; ACF30186.1; -; Genomic_DNA.
DR RefSeq; WP_003691632.1; NC_011035.1.
DR AlphaFoldDB; B4RN19; -.
DR GeneID; 66753511; -.
DR KEGG; ngk:NGK_1529; -.
DR HOGENOM; CLU_012300_3_0_4; -.
DR Proteomes; UP000002564; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ACF30186.1}.
FT DOMAIN 58..157
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 399..460
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 642..718
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 718 AA; 80159 MW; 2977B3D699563D3A CRC64;
MPAPQPSAPY DPLTAEARTL LFHTASYLKP EEQAELEKAV AYAFRAHDGQ TRKSGDPYIT
HPIAVATQLA LWHMDIQGLC AGVMHDVLED TGVTKGEMAA VFGNTVAEMV DGLSKLEKLK
FEDHAEHQAE SFRKLILAMT KDVRVIVVKL ADRLHNMRTL GSMRPDKRRR IARETLEIYA
QIANRIGLNN AYRELQDLSF QNLHPNRYET LKKAMDKSRK NRQDVVGKVL RAFGQRLVGA
NIEAKIKGRE KNLYGIHQKM MAKKLRFAEV MDIYGFRVIV NSIPACYAAL GTLHTLYQPK
PGRFKDYIAI PKSNGYQSLH TILVGPYGLP IEVQIRTREM DAVAEGGIVG HWSYKSDSKT
VDQAVLHTNQ WLKNILDLQA SSANAIEFLE HVKVDLFPNE IYILTPKGKI LTLPKGATPV
DFAYAVHTDI GHKTVAARVN NVMMPLRTKL KTGDSVEIIT SEHAKPNPAW LNFAVSGRAR
SAIRQYIKNL NRHDAVVLGE SLLQKALSSL LPKDVLLSDG IKEKYLADLN DKQTSFEEVL
YNVGMGHTLP VYVAMHIAEL AGEHFGSEVR LSSIKVDGQE SGHIHFAECC HPVPGDSIRL
LLVKGKGMII HRDTCPTLLK SDPEQQLDAD WENMNGQNYR VGLQVQSEDS HGLLALMAQA
ISDSGADIES VETPSKSQSG TEGFVEFKFL LKVKNLDQLN QIIQNLHSIP YIRKVIRS
//
