ID   B4UA05_HYDS0            Unreviewed;       300 AA.
AC   B4UA05;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=6-phosphogluconate dehydrogenase, decarboxylating {ECO:0000313|EMBL:ACG57966.1};
GN   OrderedLocusNames=HY04AAS1_1281 {ECO:0000313|EMBL:ACG57966.1};
OS   Hydrogenobaculum sp. (strain Y04AAS1).
OC   Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae;
OC   Hydrogenobaculum.
OX   NCBI_TaxID=380749 {ECO:0000313|EMBL:ACG57966.1};
RN   [1] {ECO:0000313|EMBL:ACG57966.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Y04AAS1 {ECO:0000313|EMBL:ACG57966.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Kiss H., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Resenback A.-L., Mead D.;
RT   "Complete sequence of Hydrogenobaculum sp. Y04AAS1.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00008419}.
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DR   EMBL; CP001130; ACG57966.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4UA05; -.
DR   STRING; 380749.HY04AAS1_1281; -.
DR   KEGG; hya:HY04AAS1_1281; -.
DR   eggNOG; COG1023; Bacteria.
DR   HOGENOM; CLU_024540_0_0_0; -.
DR   OrthoDB; 9804542at2; -.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR004849; 6DGDH_YqeC.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006183; Pgluconate_DH.
DR   NCBIfam; TIGR00872; gnd_rel; 1.
DR   PANTHER; PTHR11811; 6-PHOSPHOGLUCONATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11811:SF67; 6-PHOSPHOGLUCONATE DEHYDROGENASE YQEC-RELATED; 1.
DR   Pfam; PF00393; 6PGD; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   SMART; SM01350; 6PGD; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Gluconate utilization {ECO:0000256|ARBA:ARBA00023064}.
FT   DOMAIN          168..300
FT                   /note="6-phosphogluconate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01350"
SQ   SEQUENCE   300 AA;  33894 MW;  ED1B8B285B82C78F CRC64;
     MKIAFSGLGR MGIGLSRRLK EKGHEVFGFD RNQHCTKEAS SYGVKCFGTY KEMFEAFEGD
     RRVLWIMVPQ SAVDDVINEA LPYLKEGDLI IDGGNSYYKD SIRRYNTLKE KSIKFLDVGT
     SGGVWGYERG FSLMVGGDKE DFYFISPILK DLANEGVGFG YMGGPGMGHF VKMVHNAVEY
     GMMESIAEGL DLIKTSKPEV DLKEAVRVWT KGSVVASWLM DLTYKALCDF GLLEEIKPYV
     EDTGEGRWSV LEAVNEGVAM PSISNALFMR FRSREQESFR DRVLAALRYE FGQHKFKKDE
//