ID B4UHN5_ANASK Unreviewed; 807 AA.
AC B4UHN5;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Heavy metal translocating P-type ATPase {ECO:0000313|EMBL:ACG72470.1};
GN OrderedLocusNames=AnaeK_1237 {ECO:0000313|EMBL:ACG72470.1};
OS Anaeromyxobacter sp. (strain K).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Anaeromyxobacteraceae; Anaeromyxobacter.
OX NCBI_TaxID=447217 {ECO:0000313|EMBL:ACG72470.1, ECO:0000313|Proteomes:UP000001871};
RN [1] {ECO:0000313|EMBL:ACG72470.1, ECO:0000313|Proteomes:UP000001871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|EMBL:ACG72470.1,
RC ECO:0000313|Proteomes:UP000001871};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G.,
RA Beliaev A.;
RT "Complete sequence of Anaeromyxobacter sp. K.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR EMBL; CP001131; ACG72470.1; -; Genomic_DNA.
DR RefSeq; WP_012525294.1; NC_011145.1.
DR AlphaFoldDB; B4UHN5; -.
DR KEGG; ank:AnaeK_1237; -.
DR HOGENOM; CLU_001771_0_3_7; -.
DR OrthoDB; 9759222at2; -.
DR Proteomes; UP000001871; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR021993; ATPase-cat-bd.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF5; CATION-TRANSPORTING P-TYPE ATPASE-RELATED; 1.
DR Pfam; PF12156; ATPase-cat_bd; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 203..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 417..438
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 450..472
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 760..777
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 80..146
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 807 AA; 84496 MW; 45B862FD01F8BD87 CRC64;
MRCDHCLLEF PEREAVRAEV AGAPKVFCCA GCRGVFELIQ GEGLGAYYDS RRWTEVGPQA
AAALDLAAFR EAVREGHGAA ELDVAIDGIR CASCVWLNEK LLQRTPGVLS ARVNYATHRA
RIRFDPAAVG LERVLGRIQA AGYQPKPWSD AEQLRARRAE AKDLLVRLGT ALFLASQLMI
YQAALYAGYF QGIDASTRRL MEWISLGLAL PVVFYSGAPF LRATWRGLRH LRFNMDSLVV
IGSLAALAYS VHGMLRGGEV YFDTAAMIPT LVLVGRYVEA AAKGRASEAV ARLASLAPRE
ARRLERGPGG RAERRSVPVA EIRPGDRIEV IPGERIPLDG VVREGASEVD ESLVTGESRP
VAKGAGAAVI GGTVNQHGAL VVEVTRVGKD TVLAGIVRAV EEAQAQKPRI QAVADRVVGG
FVPAMLVLAA LTVAAWLARG APVERALMTG ISVVVIACPC ALGLATPIAV LVSTGLASAR
GLLVKGGDVV ERAGRATDVL LDKTGTVTRG RPALRALVPL DPSVGADEAL ALAAAVERRS
EHHVGRAVAE AARALPAGAE PEAAGFRAVP GRGVIAQVGG AEVLVGNRAL LAERGVALAP
EADARARALE AHGDTVAFLA RGGRALALVA VADPIREEAP AAIAALRALG LRVAIVSGDG
RVTTGAVAAA LGVEAVAEAS PVEKREAVAA RQRAGRRVLF AGDGINDAPA LTQAEVGAAM
GRGADVTMES ADAVLVRDDL RLLPDLVRLS RRTYAVIRQN VFWAFFYNAV AIPLAMAGLL
HPIVAAGAMA ASSLFVVGNS ARLRRAL
//
