ID B4V9G4_9ACTN Unreviewed; 622 AA.
AC B4V9G4;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:AKL66201.1};
DE SubName: Full=IolD protein {ECO:0000313|EMBL:EDX24601.1};
GN ORFNames=M444_13165 {ECO:0000313|EMBL:AKL66201.1}, SSAG_04209
GN {ECO:0000313|EMBL:EDX24601.1};
OS Streptomyces sp. Mg1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=465541 {ECO:0000313|EMBL:EDX24601.1, ECO:0000313|Proteomes:UP000005764};
RN [1] {ECO:0000313|EMBL:EDX24601.1, ECO:0000313|Proteomes:UP000005764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:EDX24601.1,
RC ECO:0000313|Proteomes:UP000005764};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Mehta T., Alvarado L., Kodira C.D., Straight P.,
RA Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA Lander E., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces sp. Mg1.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKL66201.1, ECO:0000313|Proteomes:UP000035653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL66201.1,
RC ECO:0000313|Proteomes:UP000035653};
RX PubMed=23908282;
RA Hoefler B.C., Konganti K., Straight P.D.;
RT "De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using PacBio
RT Single-Molecule Sequencing.";
RL Genome Announc. 1:e00535-13(2013).
RN [3] {ECO:0000313|EMBL:AKL66201.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL66201.1};
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CP011664; AKL66201.1; -; Genomic_DNA.
DR EMBL; DS570412; EDX24601.1; -; Genomic_DNA.
DR RefSeq; WP_008741623.1; NZ_DS570412.1.
DR AlphaFoldDB; B4V9G4; -.
DR STRING; 465541.M444_13165; -.
DR KEGG; strm:M444_13165; -.
DR PATRIC; fig|465541.12.peg.2862; -.
DR eggNOG; COG3962; Bacteria.
DR HOGENOM; CLU_013748_6_0_11; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000005764; Unassembled WGS sequence.
DR Proteomes; UP000035653; Chromosome.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AKL66201.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000035653};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 4..123
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 218..351
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 415..571
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 622 AA; 66188 MW; C6953C23107A5B7D CRC64;
MRLTVAQALV RFLARQYTER DGQRHRLIAA TWGIFGHGNV AGIGQALLET GHEEMPFLQG
RNEQAMVHAA VGFARQSGRL SAHAVTTSIG PGATNLVTGA ALATINRIPV LLLPGDSFAT
RPADPVLQQL EVPYAGDISV NDTLRPVSRF FDRVMRPEAL IPAALQAVRV LTDPVQTGAV
TLALPQDVQA EAWEWPEEFF RERVWGVRRP RPDAAELAEA AEAVRGSARP LLIAGGGIRH
SGAQAALAEF AEATGIPVAT TQAGKGALPY DHPAEVGGVG HTGTGTADGL AREADLVIAA
GTRLTDFTTA SATLFQNPAV RFLGLNLDPF DAHKLAARPL VSDAREGLEE LRRAVAGYHV
DTAYESTYKE RKRLWEERVD RAYAASGEDD APTQAQVLGL LDALVDDGDI LINAAGSLPG
DLHKLWRARS ADQYHVEYGY SCMGYEIPAA IGVALAAPGR PVWALVGDGT YLMNPTEIVT
AVQEGIAVKL VILDNHGYAS IGGLSGAVGG EGFGTAYRFR AVDGMYSGAP LPVDLAANAA
SLGMAVIRTR TIGDLRKALA EARAADRPTC VYAQTRTPDT VSGPPPAQAW WDVPVAETAT
RAAAALAREE YDRQAAQRRR HL
//
