ID   B4YT48_9CARA            Unreviewed;       562 AA.
AC   B4YT48;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012418};
DE            EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
DE   Flags: Fragment;
OS   Bembidion umbratum.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Adephaga; Caraboidea; Carabidae;
OC   Trechinae; Bembidiini; Bembidion; Notaphus.
OX   NCBI_TaxID=528239 {ECO:0000313|EMBL:ACF35387.1};
RN   [1] {ECO:0000313|EMBL:ACF35387.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18644735; DOI=10.1016/j.ympev.2008.05.023;
RA   Wild A.L., Maddison D.R.;
RT   "Evaluating nuclear protein-coding genes for phylogenetic utility in
RT   beetles.";
RL   Mol. Phylogenet. Evol. 48:877-891(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC       {ECO:0000256|ARBA:ARBA00006460}.
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DR   EMBL; EU677591; ACF35387.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4YT48; -.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 1.10.132.30; -; 1.
DR   Gene3D; 6.10.250.2940; -; 1.
DR   Gene3D; 6.20.50.80; -; 1.
DR   Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR   InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR   InterPro; IPR007066; RNA_pol_Rpb1_3.
DR   InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR   InterPro; IPR007083; RNA_pol_Rpb1_4.
DR   InterPro; IPR007081; RNA_pol_Rpb1_5.
DR   InterPro; IPR007075; RNA_pol_Rpb1_6.
DR   InterPro; IPR038120; Rpb1_funnel_sf.
DR   PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR   PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR   Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR   Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR   Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR   Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR   SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1..154
FT                   /note="RNA polymerase Rpb1"
FT                   /evidence="ECO:0000259|Pfam:PF04983"
FT   DOMAIN          181..285
FT                   /note="RNA polymerase Rpb1"
FT                   /evidence="ECO:0000259|Pfam:PF05000"
FT   DOMAIN          292..562
FT                   /note="RNA polymerase Rpb1"
FT                   /evidence="ECO:0000259|Pfam:PF04998"
FT   DOMAIN          360..541
FT                   /note="RNA polymerase Rpb1"
FT                   /evidence="ECO:0000259|Pfam:PF04992"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACF35387.1"
FT   NON_TER         562
FT                   /evidence="ECO:0000313|EMBL:ACF35387.1"
SQ   SEQUENCE   562 AA;  63322 MW;  2BB00EF86A1A6736 CRC64;
     QDTLTAVRKM TKRDVFINKE QMMNLLMFLP IWDGKMPRPA ILKPCPLWTG KQVFSLIIPG
     NVNMIRTHST HPDEEDDGPY KYISPGDTKV MVEHGELVMG ILCKKTLGTS AGSLLHICFL
     ELGHEVCGRF YGNIQTVINN WLLLEGHSIG IGDTIADPQT YVEIQKAIKK AKEDVIEVIQ
     KAHNMELEPT PGNTLRQTFE NQVNRILNDA RDKTGGSAKK SLTEYNNLKA MVVSGSKGSN
     INISQVIACV GQQNVEGKRI PFGFRKRTLP HFIKDDYGPE SRGFVENSYL AGLTPSEFYF
     HAMGGREGLI DTAVKTAETG YIQRRLIKAM ESVMVHYDGT VRNSVGQLIQ LRYGEDGLCG
     EMVEFQTLPT VKLSNKAFEK KYRFDPSNER YLRRIFNEDI IKQLMGSSDV ISELEREWEQ
     LSRDREALRQ IFPSGESKVV LPCNLQRMIW NVQKIFHINK RSPTDLSPIR VIQGVRDLLQ
     KCVIVAGEDR LSKQANENAT LLFQCLVRAT LCTKCVSEEF RLSTEAFEWL IGEIETRFQQ
     AQSAPGEMVG ALAAQSLGEP AT
//