ID B4Z8Q0_CHATO Unreviewed; 229 AA.
AC B4Z8Q0;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ACF26425.1};
OS Chauna torquata (Southern screamer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anhimidae;
OC Chauna.
OX NCBI_TaxID=30388 {ECO:0000313|EMBL:ACF26425.1};
RN [1] {ECO:0000313|EMBL:ACF26425.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18583609; DOI=10.1126/science.1157704;
RA Hackett S.J., Kimball R.T., Reddy S., Bowie R.C., Braun E.L., Braun M.J.,
RA Chojnowski J.L., Cox W.A., Han K.L., Harshman J., Huddleston C.J.,
RA Marks B.D., Miglia K.J., Moore W.S., Sheldon F.H., Steadman D.W.,
RA Witt C.C., Yuri T.;
RT "A phylogenomic study of birds reveals their evolutionary history.";
RL Science 320:1763-1768(2008).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU737980; ACF26425.1; -; Genomic_DNA.
DR AlphaFoldDB; B4Z8Q0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 124..229
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF26425.1"
FT NON_TER 229
FT /evidence="ECO:0000313|EMBL:ACF26425.1"
SQ SEQUENCE 229 AA; 25738 MW; 9AD164E18B5E812A CRC64;
VISYFSCMKA APMKEASVRG QGSLAYPGLR THGTLESLNG PNAGSRGLTS LADTFEHVIE
ELLDEDQDIQ PSEENKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH
SDPARRGELS VCDSTSEWVT AAEKKTAVDM SGATVTVLEK VPVPKGQLKQ YFYETKCNPK
GYTKEGCRGI DKRHWNSQCR TTQSYVRALT MDNKKRVGWR FIRIDTSCV
//
