ID B4ZE78_BUCAB Unreviewed; 236 AA.
AC B4ZE78;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Nerve growth factor beta polypeptide {ECO:0000313|EMBL:ACF32196.1};
DE Flags: Fragment;
GN Name=NGF {ECO:0000313|EMBL:ACF32196.1};
OS Bucorvus abyssinicus (Northern ground-hornbill) (Abyssinian
OS ground-hornbill).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucorvidae; Bucorvus.
OX NCBI_TaxID=153643 {ECO:0000313|EMBL:ACF32196.1};
RN [1] {ECO:0000313|EMBL:ACF32196.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18583609; DOI=10.1126/science.1157704;
RA Hackett S.J., Kimball R.T., Reddy S., Bowie R.C., Braun E.L., Braun M.J.,
RA Chojnowski J.L., Cox W.A., Han K.L., Harshman J., Huddleston C.J.,
RA Marks B.D., Miglia K.J., Moore W.S., Sheldon F.H., Steadman D.W.,
RA Witt C.C., Yuri T.;
RT "A phylogenomic study of birds reveals their evolutionary history.";
RL Science 320:1763-1768(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783}.
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DR EMBL; EU740092; ACF32196.1; -; Genomic_DNA.
DR AlphaFoldDB; B4ZE78; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001789-1}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..236
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013220523"
FT DOMAIN 124..228
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 132..197
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 175..225
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 185..227
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF32196.1"
SQ SEQUENCE 236 AA; 26445 MW; F9439988893006BB CRC64;
LYYTLITAFL ISTQAAPKSE DNAPLEYPAE RSLLNTHLSN RHHIPTAAPQ TSHSLSTWTT
GRREAINITM DPKIFRRRRF QSPRVLFSTQ PPPVSGQGQN MGFLSSAGSL NRTARTKRTA
HPVLHRGEFS VCDSVSMWVG DKTTATDIKG KEVTVLGEVN INNNIFKQYF FETKCRDPKP
VSSGCRGIDA KHWNSYCTTT HTFVKALTME GKQAAWRFIR IDTACVCVLS RKSGRP
//
