ID   B4ZEA7_9CHAR            Unreviewed;       236 AA.
AC   B4ZEA7;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   SubName: Full=Nerve growth factor beta polypeptide {ECO:0000313|EMBL:ACF32225.1};
DE   Flags: Fragment;
GN   Name=NGF {ECO:0000313|EMBL:ACF32225.1};
OS   Dromas ardeola.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Charadriiformes; Dromadidae; Dromas.
OX   NCBI_TaxID=458190 {ECO:0000313|EMBL:ACF32225.1};
RN   [1] {ECO:0000313|EMBL:ACF32225.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18583609; DOI=10.1126/science.1157704;
RA   Hackett S.J., Kimball R.T., Reddy S., Bowie R.C., Braun E.L., Braun M.J.,
RA   Chojnowski J.L., Cox W.A., Han K.L., Harshman J., Huddleston C.J.,
RA   Marks B.D., Miglia K.J., Moore W.S., Sheldon F.H., Steadman D.W.,
RA   Witt C.C., Yuri T.;
RT   "A phylogenomic study of birds reveals their evolutionary history.";
RL   Science 320:1763-1768(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783}.
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DR   EMBL; EU740121; ACF32225.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4ZEA7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR020425; Nerve_growth_factor_bsu.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR00268; NGF.
DR   PRINTS; PR01913; NGFBETA.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR001789-1}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..236
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013175235"
FT   DOMAIN          124..228
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   REGION          18..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        132..197
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   DISULFID        175..225
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   DISULFID        185..227
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACF32225.1"
SQ   SEQUENCE   236 AA;  26362 MW;  14A4243A43F993FA CRC64;
     LYYTLIIAFL IGTQAAPKSE GNAPLEYPAE HSPLNTHRSN RHHIPKAAPQ TSHGHSTWTT
     GTREAINITM DPKFFKKRRF RSPRVLFSTQ PPPVSGQGQN MGFLSNAGSL NRTARTKRTA
     HPVLHRGEFS VCDSVSMWVG DKTTATDIKG KEVTVLGEVN INNNVFKQYF FETKCRDPKP
     VSSGCRGIDA KHWNSYCTTT HTFVKALTME GKQAAWRFIR IDTACVCVLS RKSGRP
//