ID B4ZEH1_9PSIT Unreviewed; 236 AA.
AC B4ZEH1;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Nerve growth factor beta polypeptide {ECO:0000313|EMBL:ACF32289.1};
DE Flags: Fragment;
GN Name=NGF {ECO:0000313|EMBL:ACF32289.1};
OS Platycercus elegans (crimson rosella).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Platycercus.
OX NCBI_TaxID=269190 {ECO:0000313|EMBL:ACF32289.1};
RN [1] {ECO:0000313|EMBL:ACF32289.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18583609; DOI=10.1126/science.1157704;
RA Hackett S.J., Kimball R.T., Reddy S., Bowie R.C., Braun E.L., Braun M.J.,
RA Chojnowski J.L., Cox W.A., Han K.L., Harshman J., Huddleston C.J.,
RA Marks B.D., Miglia K.J., Moore W.S., Sheldon F.H., Steadman D.W.,
RA Witt C.C., Yuri T.;
RT "A phylogenomic study of birds reveals their evolutionary history.";
RL Science 320:1763-1768(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU740185; ACF32289.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001789-1}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..236
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012248974"
FT DOMAIN 124..228
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 22..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 132..197
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 175..225
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 185..227
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF32289.1"
SQ SEQUENCE 236 AA; 26501 MW; 8285258D6E09E16D CRC64;
LYYTLIIAFL IGTQAAPKSE DNVPLEYPAE HSSLNTHRSN RHHIPKAAPQ TSQGYSTWTI
XRREAINITM DPKVFKKRRF RSPWVLFSTQ PPPVSGQGNN MGFLSSAGAL NRTARTKRTA
HPVLHRGEFS VCDSVSMWVG DKTTATDIKG KEVTVLGEVN INNNVFKQYF FETKCRDPKP
VSSGCRGIDA KHWNSYCTTT HTFVKALTME GKQAAWRFIR IDTACVCVLS RKSGRP
//
