ID B4ZEY6_PODAU Unreviewed; 242 AA.
AC B4ZEY6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NTF3 {ECO:0000313|EMBL:ACF34598.1};
OS Podiceps auritus (Horned grebe) (Colymbus auritus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Podicipediformes; Podicipedidae; Podiceps.
OX NCBI_TaxID=37050 {ECO:0000313|EMBL:ACF34598.1};
RN [1] {ECO:0000313|EMBL:ACF34598.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18583609; DOI=10.1126/science.1157704;
RA Hackett S.J., Kimball R.T., Reddy S., Bowie R.C., Braun E.L., Braun M.J.,
RA Chojnowski J.L., Cox W.A., Han K.L., Harshman J., Huddleston C.J.,
RA Marks B.D., Miglia K.J., Moore W.S., Sheldon F.H., Steadman D.W.,
RA Witt C.C., Yuri T.;
RT "A phylogenomic study of birds reveals their evolutionary history.";
RL Science 320:1763-1768(2008).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; EU740350; ACF34598.1; -; Genomic_DNA.
DR AlphaFoldDB; B4ZEY6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 137..242
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 145..210
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 188..239
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 198..241
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF34598.1"
FT NON_TER 242
FT /evidence="ECO:0000313|EMBL:ACF34598.1"
SQ SEQUENCE 242 AA; 27933 MW; 1814CBF766225B39 CRC64;
IFLAYLRGIQ STNMDQRRLP EDSINSLIIK LIQADVLKNK LSKQMVDIKE NYQNTVQKAD
TQHDMDGDEN VKSDFQPVIS MDTDLLRQQR RYNSPRVLLS DNTPLEPPPL YLMEDYIGNS
VVVNRTSRRK RYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK
QYFYETRCKE AKPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV
CA
//
