ID B4ZF00_9GRUI Unreviewed; 242 AA.
AC B4ZF00;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NTF3 {ECO:0000313|EMBL:ACF34612.1};
OS Sarothrura elegans (buff-spotted flufftail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Rallidae; Sarothrura.
OX NCBI_TaxID=156766 {ECO:0000313|EMBL:ACF34612.1};
RN [1] {ECO:0000313|EMBL:ACF34612.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18583609; DOI=10.1126/science.1157704;
RA Hackett S.J., Kimball R.T., Reddy S., Bowie R.C., Braun E.L., Braun M.J.,
RA Chojnowski J.L., Cox W.A., Han K.L., Harshman J., Huddleston C.J.,
RA Marks B.D., Miglia K.J., Moore W.S., Sheldon F.H., Steadman D.W.,
RA Witt C.C., Yuri T.;
RT "A phylogenomic study of birds reveals their evolutionary history.";
RL Science 320:1763-1768(2008).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; EU740364; ACF34612.1; -; Genomic_DNA.
DR AlphaFoldDB; B4ZF00; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 137..242
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 145..210
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 188..239
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 198..241
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF34612.1"
FT NON_TER 242
FT /evidence="ECO:0000313|EMBL:ACF34612.1"
SQ SEQUENCE 242 AA; 27847 MW; AD8D505486EA3248 CRC64;
IFLAYLRGIQ STNMDQRSLP EESINSLIIK LIQADILKNK LSKQMVDIKE NYQNTVQKAD
TQQDMDGDEN VKSDFQPVIS MDTDLLRQQR RYHSPRVLLS DNTPLEPPPL YLTEDYIGNS
VVVNRTSRQK RYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK
QYFYETRCKE AKPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV
CA
//
