ID B5A9P9_9PSEU Unreviewed; 6775 AA.
AC B5A9P9;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=MbcAI {ECO:0000313|EMBL:ACF35445.1};
DE SubName: Full=SDR family NAD(P)-dependent oxidoreductase {ECO:0000313|EMBL:QUF05212.1};
GN Name=mbcAI {ECO:0000313|EMBL:ACF35445.1};
GN ORFNames=KCV87_03615 {ECO:0000313|EMBL:QUF05212.1};
OS Actinosynnema pretiosum subsp. pretiosum.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinosynnema.
OX NCBI_TaxID=103721 {ECO:0000313|EMBL:ACF35445.1};
RN [1] {ECO:0000313|EMBL:ACF35445.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 31280 {ECO:0000313|EMBL:ACF35445.1};
RA Zhang M.-Q., Gaisser S., Nur-E-Alam M., Sheehan L.S., Vousden W.A.,
RA Gaitatzis N., Peck G., Coates N.J., Moss S.J., Radzom M., Foster T.A.,
RA Sheridan R.M., Gregory M.A., Roe S.M., Prodromou C., Pearl L., Boyd S.M.,
RA Wilkinson B., Martin C.J.;
RT "Optimizing Natural Products by Biosynthetic Engineering: Discovery of Non-
RT quinone Hsp90 Inhibitors.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QUF05212.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 31280 {ECO:0000313|EMBL:QUF05212.1};
RA Bai L., Wang X., Xiao Y.;
RT "Genomic sequence of Actinosynnema pretiosum subsp. pretiosum ATCC 31280
RT (C-14919).";
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
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DR EMBL; EU827593; ACF35445.1; -; Genomic_DNA.
DR EMBL; CP073249; QUF05212.1; -; Genomic_DNA.
DR Proteomes; UP000677152; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 2.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 3.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 6.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 2.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 4.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00829; PKS_ER; 2.
DR SMART; SM00822; PKS_KR; 4.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 10.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1022..1097
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1119..1542
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3061..3136
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3160..3586
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5100..5175
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5195..5621
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6607..6682
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 569..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3589..3622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4175..4216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6775 AA; 697028 MW; D8AADCAD88B6F3C2 CRC64;
MLRTDLIRPV PELLGANADR FGDRTAYSDG RRSVGHAGLE RRTRRLAGHL GQLRLHPGDR
AMICLGNRVE MIESYFGVLR ADAVAVPVNP RSTDAELTHL LADSGARLVI TDAARAERFD
RLRAERFGDL TVIATQDGPL PDGVIAFEPL AAEEPELPAR DGLGLDDVAW MLYTSGTTGR
PKGVLSTQRS CLWSVAACYV PVPDLRAEDR VLWPLPLFHS LSHITCLLAA TAVGATTRIV
DGTSAQDVLA ALEQERSTFL AGVPTLYRYL VDAARERGFT APDLRVGLVG GAVTTAELLR
AFEDTFGVPL IDAYGSTETC GAIAVNWPTG ARVAGSCGLP VPGLTVRLVD PETLLDVPAG
REGEFWVSGP SVMLGYHNQP EATAEVLRDG WYRTGDLGRR DEAGFCTVTG RIKEMIIRGG
ENVHPGEVEA VVRAVPGVAD VAVVGKPHDV LGEVPVVFVV PGAGGFDPAA VLAACREELS
YFKVPEEVYE IERVPRTASG KTTRHVLLDL PARLRAASSG QFQSLLRLDW VPRTALPGEE
VPASWVLVDG DPLGLADGLR ATGARVRVGE PGADALGDGG SDADEPGASS AGEPGSGGSG
EPGSGGSGEP GSGEPGASSA GEPGAGEPGA AEPPQVVLVA AVPGERGEVA RDVEALADGL
ARRLVGWLAD ERFAGARFVV ATSGAVSTSP GEDLRELRAA PLWGVVRSVQ AAFPGRVVAA
DLDASGDGRA AALARVVAGG HDQVAVRGDV PLAPRLARVS VPSDPAPAPA LDPDGLVVVT
GGDSARGAAL ARHLVAAHGA RRLLLVSPDG LPDQAAADLE AGFAAAGARA ESVVCDPADP
VALRALLDAQ DRPVTAVVHV QGGRALLDSA RALVALHELT RQARPALFVV VTSVAGLLGS
AGDPARAAAD QFAEALVRRR ADRGLPGLAV AWGPLPGEPA QAGAGALPMA EALTLVDAAL
AADQGPLVVL GLDAVGSRRA VGAVPPVLHD LVDGGRAARV APGAVAEFTR RLAEAGGQRA
RRVALDLVRE HVAAALGLPE DTPVRADQAF RDFGVTSLTA VALRDRINAA TGASLPATAV
FDHPTPAALA DHLVREVTGD RPHVERARDE RARGTSRADE PVAIVAMGCR LPGGVASPED
LWRLVDEGVD AIGPFPTDRG WDLATLLDGS DSPGRSSVDR GGFLPGAGDF DAGFFGISPR
EALAMDPQQR LLLEVVWETV ERAGIDPRSL HGEDVGVFSG LMYHDYGTEP GSAPEGLEGF
VSTGSAGSVV SGRVAYALGL TGPALTVDTA CSSSLVAIHL AAQALRSGEC SMALAGGVAV
MGQPTSFVEF SRQRGLAADG RCKSFSDDAD GTNWAEGVGV LLLERLSDAR RDGHPVLAVL
RGSAVNQDGA SNGLTAPSGP AQQRVIRQAL ANAGLRPSEV DAVEAHGTGT TLGDPIEAQA
LLATYGQDRE QPLWLGSLKS NLGHAQAAAG VAGVIKMVMA LRHGVLPRTL HVGTPSSKVD
WSAGAVELLT EARPWRANGR PRRAGVSSFG VSGTNAHVVV EEHREPAAAP VDPVSPGLAV
SGGVAPLVLS GRTRSALAAQ AAALLGHLAD GTDPAALGRA LATTRTAFEH RAAVLAPDVD
AARAGVRALA EDRPAPNLVT GQADVDGPVV FVFPGQGAQW TGMGRELLET SPVFAARLRE
CSEALERWTG WSLLDLLADG AELDRVDVLQ PASWAVMVAL AALWESCGVR PDAVVGHSQG
EVAAACAAGW LSLDDAARVV ALRSRAIAEH LAGRGGMMSV AAGAERVAGL IADRQGRVSV
AAVNGPSATV VAGAADALPE LAARCEREGV RARIIPVDYA SHTEHVDALD GVLQEVLAGV
TAQAGHVPWL STVDGEWVDG SGLDADYWFR NLRGTVRFAD AVAALAGSGH RVFVEVSSHP
VLTAATGEVL EAAGVRDALV VGSLRRDDGG PERFLTGLAE LHARGVPVGL EAVFAGADGR
VELPTYAFQH ERYWLARGPV AGDVSGSGLV DAAHPLLGAV VPLPGTGGVL LSGRLSHRRQ
PWLAEHAVAG TVLLPGAAIV ELAVRAGDET GCGVLRELVI GQPLVVPPDA EVDLQVLVGG
PDDGGVRDLR LYSRTGAAAE WVEHAAGALA PGGAVGGARP AGARTAGARL DGARLDGQWP
PAGAEPVALE GFYENLAELG YEYGPLFRGL AAAWTRDGEV FAEAVLPEEA LSGQALSGQA
GSGQAGSGNG SGNGFGIHPA LLDGALHAGN LCVPPAPGRT LLPFAWNEVR LHATGATAVR
VRVRATGEDS LELELFDADG APVASVGGLT LRPAVTGARP AESLHEVEWT EVAAGGSWPE
VADTRDWEAA ADLPTRSREL AARALELVQD RLAGVDGAPL LVITTGAVAV ADDAEVTDPA
AAAVWGLLRS AQSEHPGRFA LVDVDGGAAA EVAALVPGDE PQTALRGGLV RAPRLRRLPP
GLVPPAGAHW HLDAVTTGTL DGLALVASEP VPLRAGEVRI EVRAAGQNFR DVLVALDGVA
GQEGIGGEGS GIVTEVGPEV TGFAAGDRVM GLFPRSFGPL AVADARTVVR VPRGWSFTDA
AAVPVAFLTA LHGLQDVAGL RAGETVLVHA AAGGVGQAAV QLAHHFGARV LATAHPAKHS
VLTALGVPAE RLASSRDLGY ARRFGDVDVV LNSLVGEHVD ASLRLLRAGG RFVEIGKNDV
RDADSVGDVR YRVFDLGADA GPDRIGELLE QLVGLFESGA LRPLPVRTWD VTRAASAFRE
MSRGGHTGKI VLTIPRRLDP EGTVLITGGA GTLGATAARH LVTAHGARNL LLVGRRGPDA
PGASELAEEL RGLGADVRVA ACDVADRAAL DALLASVPAG RPLTAVVHAA GALDDGTVTA
LTPERFDAVF RPKVDAIAHL DEATRDADLA AFVVYSSAAG VLGNAGQGNY AAANAVLDAV
ARTRHARALP ATSLAWGLWS DTSALTATMD GRAVDRTRRA GVLGMGNDEA LAALDAGLAS
GLPALVAARI DPAALRDPAS GSPLLRGLVR ATRRTAATRD RDAVGGLAGR LAGLSAAEQD
ELLLGLVRSE AAAVLGHASA ERVEPQVAFR DMGFDSLTAV ELRNRLAAAT GLRLPATATF
DHPTPVRFAA LLRGELLGAV VAPGAVTAAA APVTAAAPAD EPIAIVSMAC RLPGGVVDPA
GLWELLTGER DGIVDFPDDR GWDLESLYHP DADSPGTSYV LRGGFLDDAG GFDAGFFGIS
PREALAMDPQ QRVFLETCWE AFERAGIDPV SVRGSDTGVF AGIIDQDYGV RAGTAPEELE
GYLLTGTATS VASGRVAYLF GLEGPAVTVD TACSSSLVAT HWAVQALRRG ECSMALAGGA
TVMGRPSAFV EFSRQRGLAR DGNCKAFGAD ADGTAFSEGA GVLLLERLSD ARRRGHPVLA
VIRGSALNQD GASNGLTAPS GPAQQRVIRA ALADAGLRPS DVDAVEAHGT GTALGDPIEA
GALLATYGAD REGAEPVWLG SLKSNTGHTL AAAGVSSVIK MVLALNHGLL PRSLHVREPS
AAVDWESGGV RLLTSARPWP ESGRPRRAGV SSFGISGTNA HLVLEAAPAE EGAGARSGAA
APGPDTRSAP TPDAPAGPVQ TSGVIPWPLS ARSADALPAQ AAKLAAHVRA HDDLSPLDVG
WSLATTRTAH PHRAVLVGGT REALLSAADA LAGGEASQAV LTGSAVGSGS AKTVFVFPGQ
GAQWAGMGRE LLGSSPVFAA RLRECADALA PHTDWDLLDV VRGAEGAPGF ERVDVLQPTS
WAVMVALAAL WRSCGVEPSA VVGHSQGEVA AAVVGGYLAL GDAARLIARR SRAIAQELTG
RGGMLSVLTS PERVAELLEP WAGKLWIAAV NSPASVSVSG DAEALGEFVR VLAKARINRW
RLPGVDFAGH SGHVDGIEAR LREELADVTA AAGEVPWLST VDGRWVERTR LDADYWYRNL
RDVVRFDEAV RALVDAGHRA FVEVSTHPVL TTAIGEVADE RQDVRVAVAG TLRRDDGGAD
RVVGALGEVA ASGVAVDWAA VFGGTGAAVV ELPTYAFRHE RFWLTPSGGD VRAVGLRQAG
HPLLGAVVSV PDTGGVLLTG RLSLSAQPWL ADHALSGVPL LPGTALVELA VRAGDETGTP
VVAELVLGRP LVLPRTGSAQ VQVLVGEEAR DGRRPVAVYS RAGDDRPWTE HASGSLAPDE
DAAPGAEGDE WPPAGAEPVD LGGFYDGLAE RGYDYGPAFR GLVRGWVRGD EAFAEVGLPD
DQHGAAARFG LHPALLDAAL HAASLCAGHG RGTALPFTWT GVRLHAAGAT ALRVRLEADG
PERLSLRASD PAGTPVVTVG SLLLRAADAD RLRATAAATA AAAADDGLHA LEWTPHPLPE
ETTGSPAVLD TRAWELPEGV GRAEAITTRV LAELQAELDG TATLVVVTRG AVAVHDDAEV
TDPAAAAVWG LVRAAQAEEP GRVAVVDVDD ASEAALDAAA HAAGAEPQLA LRGGAAFAPR
LVEASGALAV PDGPWRLDST GRGTLENLAL VPNPAAGAPL APGQVRIVVR AGGLNFRDVL
IALDAYESEI GTEGAGVVVE VAPDVTRVAV GDRVMGMIPG SFGPLAVADA RTVVRMPRGW
SFTDAAGVPV AFLTALYGLR DLGGLAEGET VLVHAAAGGV GMAAVQLARH FGARVLGTAH
PAKHAALDLP ADHLASSRDL AYAQRFGDVD VVLNSLVGEH VDASLRLLRA GGRFVEMGRA
DLRDADEVAR EHPGRAYLPF DLGGDAGPDR IAELLVELVA LFESGALRPL PTRRTDLVRA
PEAFRAMSQG RHVGKLVLTP PRALDRDGTV LITGGTGTLG AALARHLVDA HGVRNLLLVS
RSGPNAPGAA DLVAELAERG ARVRVAACDV AEKDALTALL ASIPTGRPLT GVVHAAGALD
DGVLTALDAD RVAAVLRPKA DAALLLHEAT EDADLALFAL CSSVAGVLGN AGQANYAAAN
TYLDALAQHR SAAGLAALSL AWGRWAQTSA LTADLPAPGG RRDLVRPMDT ASALRLLDAA
LRTGRSTVVA AELDVTAATA ANPVLRGLVR PARRALATSA RDERGVAAAL AGLGEADRRR
FVLDLVRSHA AVVLGLAGKE AVDAERAFTE TGFDSLTAVE LRNRLAAATG LRLPSTLVFD
HATPTALAAH LRAELTGDDL PQARAVAATA GARDDDPVVI VSASCRLPGG ADSPEALWEL
LERGRDAITP FPRDRGWDLE ALYDADPDRP GKSYVRDGGF LADAAGFDAE FFGISPREAL
ATDPQQRLLA ETSWELFERA GIAPTSVRGS DVGVFAGVIN QEYGVHSGTT PAELEGYVMT
GSTTSIASGR VAYLLGLTGP AVTVDTACSS SLVAIHLAAQ ALRSGECSMA IAGGATVIAR
PGGFVSFSRQ RGAAPDGRCK AFGDGADGMA FAEGVGLVLL ERLSDARRNG HPVLAVVRGT
ALNQDGASNG LTAPNGPAQQ RVIRQALANA GLSPDEVDAV DAHGTGTALG DPIEAQALLA
TYGRDRDPRR PLWLGSVKSN IGHTQAAAGI ASVLKMVLAM QRGVLPATLH ADTPTTKVDW
SSGAVALLSR ARPWPETGRP RRAGVSSFGI SGTNAHVLLE QAPQDAPATP VAPRGAGLVG
AVAWPVSGRT PAALRAQAAR LGTHLAGAQA GPADVGWSLA GTRTAFAQRA VVVAGTAEQA
RDGLAALAEG RSSALVTTGE AGVDGRVVFV FPGQGAQWIG MGAELIDASP VFAERLRECA
EALEPFVDFD LIEVLRGRGS LERVDVVQPA SWAVMVSLAA LWRSLGVEPD AVVGHSQGEI
AAAAVSGALS LPDAAAVVAL RSKAIAQDLA GLGGMMSVAL PADDVDLSGY PGRLWVAAHN
GPTSTVVAGD VDALRELHAH YEGAEVRARI IPVDYASHTG HVDTIRERLA EALAHVRPRA
GTIPWLSTAT GEWTTGEDAD ADYWFRNLRG AVGFHTAITT LAEQGHRVFV EVSSHPVLTT
AIEATLEGTG PTAVTGTLRR DDGGPDRLLT SLATLHVRGV HVDWDAVYAG SGAHRTTLPT
YAFQHERYWL TEPDAPQAVA DAPFWDAVDS GDVAALAGSL GVEPAALEPV LPGLTSWRAR
NRDGAAVDDW SYRIGWERVD VPAAPLSGTW LVVVPEALAD DTSVAEVAAA LAARGATPRI
VAAGPDLGPD LGDEPDGVLS LLAWDDRPAG GGTLSRGVVD AVGLVREAVR RGWSAPLWCA
TLGAVAVADP GEVTAEFGPQ LWGTGVVLGL DLPDTWGGLV DLPARPDGVA LDLLCAVVAG
AGDEDQLAVR PAGVFARRMT RRPVASAPAW RPRGTVLVTG GTGGLGGYVA RWAAERGARD
VVLLSRGGPD APGADALVAD ITAAGARCAV LACDVTDRDA LAEVVANLPD GPLSVVHAAG
VARPGRPLVE TTPEEFAAIG RGKVAGARLL DELLGDRELD AFVLFSSGAA AWGSGGQAGY
AAGNAFLDGL AQRRRARGLA ATSVAWGAWG GVGTVDEVLG EQWRRAGLLT MDPRLATLAL
AHAVGSGEAH LLVADVDWAR FAPAYALARP RPLLAALPEV ADALAVVDAP ADAGGIGARL
AGLPPAEQER LLTELVQAEA AAVLGLGGIT GDRAFREVGF DSLTAVELRN RLGAATGLTL
PATLVFDHPR PSALAAHLRS ALGPAAAPVD SVAGVLAELD RLEAAIPALP SAEIGRSRLE
LRLRRLSARV GELVAANGER ANGGRANGGR AAADELDDAG AEDVLAFIDR EFGDA
//
