ID B5AZN2_ANOAR Unreviewed; 1291 AA.
AC B5AZN2;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=TEP1 {ECO:0000313|EMBL:ACG68535.1};
DE Flags: Fragment;
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EMBL:ACG68535.1};
RN [1] {ECO:0000313|EMBL:ACG68535.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ToMB10_S {ECO:0000313|EMBL:ACG68535.1};
RX PubMed=18840262; DOI=10.1186/1471-2148-8-274;
RA Obbard D.J., Callister D.M., Jiggins F.M., Soares D.C., Yan G.,
RA Little T.J.;
RT "The evolution of TEP1, an exceptionally polymorphic immunity gene in
RT Anopheles gambiae.";
RL BMC Evol. Biol. 8:274-274(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; EU881835; ACG68535.1; -; Genomic_DNA.
DR VEuPathDB; VectorBase:AARA008889; -.
DR VEuPathDB; VectorBase:AARA21_010641; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 2.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR049135; TEP1_CUB2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR Pfam; PF21412; TEP1_CUB2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 376..508
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 583..674
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1180..1269
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACG68535.1"
SQ SEQUENCE 1291 AA; 146765 MW; 1884ACE73F6EE273 CRC64;
VDLLLKLEGE TDNGLSVLNV TKMVDVRRNM NRMINFNMPE DLTAGNYKIT IDGQRGFSFH
KEAELVYLSK SISGLIQVDK PVFKPGDTVN FRVIVLDTEL KPPARVKSVY VTIRDPQRNV
IRKWSTAKLY AGVFESDLQI APTPMLGVWN ISVEVEGEEL VSKTFEVKEY VLSTFDVQVM
PSVIPLEEHQ ALNLTIEANY HFGKPVQGVA KVELYLEDDK LNQKKELTVY GKGQVELRFD
NFAMDADQQD VRVKVSFIEQ YTNRTVVKQS EITVYRYAYR VELIKESPQF RPGLPFKCAL
QFTHHDGTPA KGISGKVEVS DVGFETTTMS DNDGLIKLEL QPSEGTEQLG INFNAVDGFF
FYEDVNKVET VTDAYIKLEL KSPIKRNKLM RFMVTCTERM TFFVYYVMSK GNIIDAGFMR
PNKQTKYLLQ LNATEKMIPK AKILIATVAG RTVVYDYADL DFQELRNNFD LSIDEQEIKP
GRQIELSMSG RPGAYVGLAA YDKALLLFNK NHDLFWEDIG QVFDGFHAIN ENEFDIFHSL
GLFARTLDDI LFDSANEKTG RNALQSGKPI GKLVSYRTNF QESWLWKNVS IGRSGSRKLI
EVVPDTTTSW YLTGFSIDPV YGLGIIKKPI QFTTVQPFYI VENLPYSIKR GEAVVLQFTL
FNNLGAEYIA DVTLYNVANQ TEFVGRPDTD LSYTKSVSVP PKVGVPISFL IKARKLGEMA
VRVKASIMLG HETDALEKVI RVMPESLAQP KMDTSFFCFD DYKNQTFPFN LDINKKADNG
SKKIEFRLNP NLLTMVIKNL DNLLAVPTGC GEQNMVKFVP NILVLDYLYA TGSKEQHLID
KATNLLRQGY QNQMRYRQTD GSFGVWEKSG SSVFLTAFVA TSMQTASKYM NDIDAAMVEK
ALDWLASKQH SSGRFDETGK VWHKDMQGGL RNGVALTSYV LTALLENDIA KVKHVVVIQN
GMNYLSNQLA LINNPYDLSI ATYAMMLNGH TMKKEALDKL IDMSISDNNK KERYWGTTNQ
IETTAYALLS FVMAEKYLDG IPVMNWLVNQ RYVTGSFPRT QDTFVGLKAL TKLAEKISPS
RNDYTVQLKY KKNTKYFNIN SEQIDVQNFL EIPEDTKKLE INVGGIGFGL LEVIYQFDLN
LVNFEHRFKL DLEKQNTGSD YELRLRVCAN YIPELTDSQS NMALIEVTLP SGYVVDRNPI
SEQTTVNPIQ NMEIRYGGTS VVLYYYNMGT ERNCFTVTAY RRFKVALKRP AYVVVYDYYN
TNLNAIKVYE VDKQNVCEIC EEEDCPAECK K
//
