ID B5L6A0_9PROT Unreviewed; 306 AA.
AC B5L6A0;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:ACA13639.1};
OS Thalassospira sp. MCCC 1A02093.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Thalassospiraceae; Thalassospira.
OX NCBI_TaxID=501854 {ECO:0000313|EMBL:ACA13639.1};
RN [1] {ECO:0000313|EMBL:ACA13639.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MCCC 1A02093 {ECO:0000313|EMBL:ACA13639.1};
RA Yuan J., Lai Q., Shao Z.;
RT "Genetic analysis of complementary markers to 16S rRNA gene of
RT Thalassospira in different oceanic regions.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU440873; ACA13639.1; -; Genomic_DNA.
DR AlphaFoldDB; B5L6A0; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 105..274
FT /note="DNA topoisomerase type IIA subunit B"
FT /evidence="ECO:0000259|Pfam:PF00204"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACA13639.1"
FT NON_TER 306
FT /evidence="ECO:0000313|EMBL:ACA13639.1"
SQ SEQUENCE 306 AA; 34110 MW; 7B37456E1346A42C CRC64;
ALSTLLKLRI WRNGKEHYME FSGGDAIKPL EVVGDAPLTE DGTPLSGTEV TFYPDAEIFT
MTDFDLPTLE HRLRELAFLN SGVILTLRDE RSGDPVETKL HYEGGIRAFV EYLDRNKVRQ
IEEPISIEGE KDGITVEVAL QWNDSYHETT LCFTNNIPQR DGGTHMAGFR AALTRQINSY
AQESGIAKKE KVALSGDDAR EGLSCVISVK VPDPKFSSQT KDKLVSSEVR PVVENILNDR
LAQWLEEHPQ DARKIVTKVV EAASAREAAR KARELTRRKG ALDISSLPGK LADCQERDAS
KAELFI
//
