ID B5LVY6_SACKO Unreviewed; 389 AA.
AC B5LVY6;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Pbx homeobox protein {ECO:0000313|EMBL:ACG76359.1};
GN Name=pbx {ECO:0000313|EMBL:ACG76359.1};
OS Saccoglossus kowalevskii (Acorn worm).
OC Eukaryota; Metazoa; Hemichordata; Enteropneusta; Harrimaniidae;
OC Saccoglossus.
OX NCBI_TaxID=10224 {ECO:0000313|EMBL:ACG76359.1};
RN [1] {ECO:0000313|EMBL:ACG76359.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18574105;
RA Freeman R.M.Jr., Wu M., Cordonnier-Pratt M.M., Pratt L.H., Gruber C.E.,
RA Smith M., Lander E.S., Stange-Thomann N., Lowe C.J., Gerhart J.,
RA Kirschner M.;
RT "cDNA sequences for transcription factors and signaling proteins of the
RT hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence
RT tag (EST) approach for evolutionary and developmental studies of a new
RT organism.";
RL Biol. Bull. 214:284-302(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family.
CC {ECO:0000256|ARBA:ARBA00007601}.
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DR EMBL; EU915511; ACG76359.1; -; mRNA.
DR RefSeq; NP_001158431.1; NM_001164959.1.
DR AlphaFoldDB; B5LVY6; -.
DR EnsemblMetazoa; NM_001164959.1; NP_001158431.1; GeneID_100302728.
DR GeneID; 100302728; -.
DR KEGG; sko:100302728; -.
DR CTD; 778982; -.
DR OrthoDB; 3684468at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005542; PBX_PBC_dom.
DR PANTHER; PTHR11850:SF108; HOMEOBOX PROTEIN EXTRADENTICLE; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 49..248
FT /note="PBC"
FT /evidence="ECO:0000259|PROSITE:PS51978"
FT DOMAIN 247..310
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 249..311
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 27..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 389 AA; 42994 MW; 2A523ED6626958AC CRC64;
MEETQRHMQS LANATMAQVG QSVVHPGIMS APHMPTATDQ QQQGPEQETR KQEIGDILQQ
IMTITDQSLD EAQARYEKHA LNCHRMKPAL FSVLCEIKEK TVLSIRGAQE EEPPDPQLMR
LDNMLIAEGV AGPEKGGGSA AAVAATNAAA GGGPGQPDNA IEHTDYRAKL AQIRQIYHTE
LEKYEQACNE FTTHVMNLLR EQSRTRPIAP KEIERMVAII HRKFNAIQMQ LKQSTCEAVM
ILRSRFLDAR RKRRNFSKQA TEVLNEYFYS HLSNPYPSEE AKEELARKCG ITVAQVSNWF
GNKRIRYKKN IGKAQEEANL YAAKTAAAAA AATNQHSPTG SSGSYPMTSQ SQIMGQPDMF
MGMQQVNGDS YSASGAQVGA NVQSQSPSK
//
