ID   B5M295_9HIV1            Unreviewed;       216 AA.
AC   B5M295;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:ACH67771.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:ACH67771.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ACH67771.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ACH67771.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RT01V2C1 {ECO:0000313|EMBL:ACH67771.1};
RA   van Marle G., Church D.L., Nunweiler K.D., Cannon K., Wainberg M.A.,
RA   Gill M.J.;
RT   "Higher Levels of Zidovudine Drug-Resistance in the Colon Compared to Blood
RT   and Other Gastro-Intestinal Compartments in HIV Infection.";
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; EU931942; ACH67771.1; -; Genomic_DNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:ACH67771.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW   Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT   DOMAIN          26..216
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACH67771.1"
FT   NON_TER         216
FT                   /evidence="ECO:0000313|EMBL:ACH67771.1"
SQ   SEQUENCE   216 AA;  25317 MW;  EEE4F6897B100A5E CRC64;
     PKVKQWPLTE EKIKALVEIC TEMEKEGKIS KIGPENPYNT PVFAIKKKDS TKWRKLVDFR
     ELNKRTQDFW EVQLGIPHPA GLKKKKSVTV LDVGDAYFSV PLDIDFRKYT AFTIPSINNE
     TPGIRYQYNV LPQGWKGSPS IFQSSMTKIL EPFRKQNPDI VIYQYMDDLY VGSDLEIGQH
     RTKIEELRQH LLRWGFTTPD KKHQKEPPFL WMGYEL
//