ID   B5RJG2_DROME            Unreviewed;      1023 AA.
AC   B5RJG2;
DT   04-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   04-NOV-2008, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Vacuolar protein sorting-associated protein 18 homolog {ECO:0000256|ARBA:ARBA00017338};
DE   Flags: Fragment;
GN   Name=dor-RA {ECO:0000313|EMBL:ACH92501.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:ACH92501.1};
RN   [1] {ECO:0000313|EMBL:ACH92501.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004492}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the VPS18 family.
CC       {ECO:0000256|ARBA:ARBA00010454}.
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DR   EMBL; BT044436; ACH92501.1; -; mRNA.
DR   AlphaFoldDB; B5RJG2; -.
DR   EnsemblMetazoa; FBtr0070269; FBpp0070259; FBgn0000482.
DR   VEuPathDB; VectorBase:FBgn0000482; -.
DR   HOGENOM; CLU_003488_1_0_1; -.
DR   Bgee; FBgn0000482; Expressed in seminal fluid secreting gland and 20 other cell types or tissues.
DR   ExpressionAtlas; B5RJG2; baseline and differential.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0099023; C:vesicle tethering complex; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR007810; Pep3_Vps18.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR   Pfam; PF05131; Pep3_Vps18; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50236; CHCR; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          65..484
FT                   /note="Pep3/Vps18/deep orange beta-propeller"
FT                   /evidence="ECO:0000259|Pfam:PF05131"
FT   COILED          855..896
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACH92501.1"
SQ   SEQUENCE   1023 AA;  117560 MW;  10478BC682A083A7 CRC64;
     HFSDWGVLVE LIVNSGGKGS RMDTSMPNQP KFLPRIEHNS SGATANSYVA TASGNPFETD
     DEDEIFSRHK MVLRVPSNCT GDLMHLAVSR NWLVCLLGTP ERTTLLRFFL PRAIPPGEAV
     LEKYLSGSGY KITRMFLDPT GHHIIIALVP KSATAGVSPD FLYIHCLESP QAQQLKVRRI
     EKFKDHEITA VAFNPYHGNE SSTGPILLGT SRGLIFETEL NPAADGHVQR KQLYDLGLGR
     PKYPITGLKL LRVPNSSRYI IVVTSPECIY TFQETLKAEE RSLQAIFAGY VSGVQEPHCE
     ERKTDLTFSQ LRFFAPPNSK YPKQWAWLCG EGIRVGELSI EANSAATLIG NTLINLDFEK
     TMHLSYGERR LNTPKAFVLT EYHAVLLYAD HVRAICLLNQ EQVYQEAFDE ARVGKPLSIE
     RDELTGSIYV YTVKTVFNLR VTREERNVWR IYLDKGQYEL ATAHAAEDPE HLQLVLCQRA
     DAAFADGSYQ VAADYYAETD KSFEEVCLKF MVLPDKRPII NYVKKRLSRV TTKPMETDEL
     DEDKMNIIKA LVIWLIDLYL IQINMPDKDE EWRSSWQTEY DEFMMEAHVL SCTRQNRETV
     RQLIAEHADP RNMAQFAIAI GDYDEVVAQQ LKAECYAEAL QTLINQRNPE LFYKYAPELI
     TRLPKPTVDA LMAQGSRLEV EKLVPTLIIM ENREQREQTQ RYLEFAIYKL NTTNDAIHNF
     LLHLYAEHEP KLLMKYLEIQ GRDESLVHYD IYYAHKVCTD LDVKEARVFL ECMLRKWISA
     VDLALTFDMK LAKETASRPS DSKIRRKLWL RIAYHDIKGT NDVKKALNLL KECDLLRIED
     LLPFFADFEK IDNFKEAICD ALRDYNQRIQ ELQREMAETT EQTDRVTAEL QQLRQHSLTV
     ESQDTCEICE MMLLVKPFFI FICGHKFHSD CLEKHVVPLL TKEQCRRLGT LKQQLEAEVQ
     TQAQPQSGAL SKQQAMELQR KRAALKTEIE DILAADCLFC GLLISTIDQP FVDDWEQVNV
     EWE
//