ID B5TFF7_HBV Unreviewed; 394 AA.
AC B5TFF7;
DT 04-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 04-NOV-2008, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:ACH81453.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ACH81453.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ACH81453.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HBVDM85 {ECO:0000313|EMBL:ACH81453.1};
RX PubMed=18715605; DOI=10.1016/j.virol.2008.07.009;
RA Zehender G., Maddalena C.D., Giambelli C., Milazzo L., Schiavini M.,
RA Bruno R., Tanzi E., Galli M.;
RT "Different evolutionary rates and epidemic growth of hepatitis B virus
RT genotypes A and D.";
RL Virology 380:84-90(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; EU908828; ACH81453.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 117..360
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACH81453.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:ACH81453.1"
SQ SEQUENCE 394 AA; 44200 MW; 6184DF08D6B9EC0B CRC64;
WSIRDGFHPT ARRPFGMEPS GSGHTTNFAS KSASCLHQSP VRKAAYPAVS TFEKHSSSGH
AVELHNLPPN SARSQSERPV FPCWWLQFRN SKPCSDYCLS LIVNLLEDWG PCAEHGEHHI
RIPRTPSRVT GGVFLVDKNP HNTAESRLVV DFSQFSRGNY RVSWPKFAVP NLQSLTNLLS
SDLSWLSLDV SAAFYHLPLH PAAMPHLLVG SSGLSRYVAR LSSNSRILNH QHGTMPNLHD
SCSRNLYVSL LLLYQTFGRK LHLYSHPIIL GFRKIPMGVG LSPFLLAQFT SAICSVVRRA
FPHCLAFSYM DDVVLGAKSV SHLESLFTAV TNFLLSLGIH LNPNKTKRWG YSLNFMGYVI
GCYGSLPQDH IIQKIKECFR KLPVNRPIDW KVCQ
//
