ID B5YM02_THAPS Unreviewed; 8463 AA.
AC B5YM02;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Kringle domain-containing protein {ECO:0000259|PROSITE:PS50070};
GN ORFNames=THAPS_25392 {ECO:0000313|EMBL:ACI64325.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:ACI64325.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:ACI64325.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64325.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:ACI64325.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64325.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
RN [3] {ECO:0000313|EMBL:ACI64325.1, ECO:0000313|Proteomes:UP000001449}
RP GENOME REANNOTATION.
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64325.1};
RG Diatom Consortium;
RA Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A., Detter J.C.,
RA Schmutz J., Lindquist E., Shapiro H., Lucas S., Glavina del Rio T.,
RA Bruce D., Pitluck S., Rokhsar D., Armbrust V.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001159; ACI64325.1; -; Genomic_DNA.
DR RefSeq; XP_002295608.1; XM_002295572.1.
DR STRING; 35128.B5YM02; -.
DR PaxDb; 35128-Thaps25392; -.
DR EnsemblProtists; ACI64325; ACI64325; THAPS_25392.
DR GeneID; 7444796; -.
DR KEGG; tps:THAPS_25392; -.
DR eggNOG; ENOG502SACR; Eukaryota.
DR HOGENOM; CLU_222737_0_0_1; -.
DR InParanoid; B5YM02; -.
DR Proteomes; UP000001449; Chromosome 18.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00108; KR; 1.
DR Gene3D; 2.160.20.160; -; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 3.
DR InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR PANTHER; PTHR24261:SF7; KRINGLE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00353; HemolysinCabind; 6.
DR Pfam; PF00051; Kringle; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF51120; beta-Roll; 3.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS00330; HEMOLYSIN_CALCIUM; 2.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kringle {ECO:0000256|ARBA:ARBA00022572};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 248..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5640..5718
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT REGION 3026..3151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8428..8455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8429..8453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 8463 AA; 910954 MW; C4B5FA8168560C07 CRC64;
MSYYNKASSK PKPKQGNQVT RITMKPAPMD APVSFGFGSS MNNLIKTTFV TSLLISICGG
NAVNMWTGGK LTDDVREIGV RKEFGGGNGG EVWIDEKESF CNCEKQMYLA LESVATASFY
NEDDVAPKCT ITKLGDYDEY SVVNQDDDEN SGVGSCVRTI KYKLDAQDDE RAHASGGGGR
CDPKQGVSRV IGDGYADDAA VGLHSKEIPI NFVSAEDDEK DLPIALTYHP EDSPNGDGGT
TVVLEGELIT AITVAALVLV LALAIVMFCY RTYITSIKYF IGCVTAIVLG VFSCFEKQCY
PSHHAPTHRT NHGNTLLTLA VGLLSILTTP AWGAVTGSCL VPSDYNHYLQ EAISDLELRI
EEEVADGLNS IGFAPLGVSF PVNSILDLKS DVFEVLFGTS AERNSWLNVT TDIDIVGELT
SNLAAASVGE VISDVDIQCS LNETLQRLQI EFTLSGSLDD SVLTSLGVSP DIAVLPDSFP
SLDVNLATLE ATYDLILPLT IDIPRKKVQL GETKANFNIL IGGEVAQSLS ILPTGDAAVS
FAGSLDMNAV FSFSSIDSWV YNGNYLASLS GEIEEGGAAA NLTLTAFDDD FFDDKPPSVS
FSFDVCEFVD LIKTSIDQFG LSEELNTLLD KYFDPFLVKA SFLPSTLTDI VKTTIATAAK
EKVNEVKGRI VNELDGLVGT CSARRLGAIE INEDGTQRLL SNEFTFDALA NTIKNFDGVE
SAVAGYFAGR NEIALDVGIH LEVSFATDEF EEAISKVFEL LSPAQAMFGA NGSADVGTLL
GNAQSVAVFN LAISTGFKIG DLAEFFSSPT ATSSSIGSLF FSIIDLGITA EASASGMNFD
LFSSPNIGVV DGSFLLSVGS RLAAPFEVEL NALGNPINVA DFSTLLTGRL DLVPHGQLSA
SLPFSAEIGS STQELTVILE DSDLFNGEQV SVRVDFDACQ VAPFIDGLLA KMGSFSVSGE
SLLGNVGFSG IDFGGIDEYL PDVGEFTGGA LEAKNEFFHI CQEVEETGER GPTLEDVKAL
ILEVVDLPRR VVANEHYTKL VPAVLLLLPW RDFNPVVIVL YVQHIHLQSV AVVPYVPIIS
HSTITRGLAH QHKTIVICKD LSDLDSIIER PLELLREISF VNDLFEGDLS SISFDADISF
IAGTHVGVTV GFLLNSTEFV DIPSMNSTEL ATRAYMQFND ISAKFSATAR VSGSISLGES
TLGVDDGVIA FGFGFGMVER SDKIFFRDIS SASLAMRENG KWNQVGGMDI SLPVNVSIGA
LGGSLNLKPL ISITDSDLLG PDSPAISIDF DVGELFDGGE NIIGSLLEQL TGGLADISSG
GIPDFSGGPL GEIQGVLDGF GLNLTSMFEE FKSYYDDFKS DILSGGSEYQ ALVNLKPISL
PRFSGLLQLG SKLPSVQYSH QLTKLLWDKL QTTFSSTTYN GVKIPDIPLG ETFKMAYPTR
GDFPVAYGYA PSFSDPNALS FTMNKLFAPK FGVDLTTRLL TTLQGNIDNT FDGFSLIDFT
TSSGEVFDIE KYLPEIQYAP KLSPSVDFAA SNFQSSDLFD ALFPSSIPSV KAMGNFVKKK
IIAKITTALE GLFDVGIDVP GVDLGLSVSQ PILNGSGASF GVYTEDSTKL FPPVLDVDAV
QGFSFDLDID VVDGGVVLSA RFILDVEGVN PIETLSEIAS SLSNTIEALS GDFENIVGSF
DDSFSSTADL LGMIAESDKI LLLLDASIDF AVNADLTMGS LQVTSALTEL RTSLHAYISD
EFDFSVGGYG VSVAPSITVY LEAENKETPF DVFANPGGLT NFSFGGTFDG MVSVGVEGVP
AQITMRASSD DITVLSAFDF ELRLDIDLSP IKDIIISLLT DIGELSYPSW LTKTAPFLPP
LDLSCVSKAG IAFSERTDLT VSSLLSSIYD LCPGAFSLSG GYSPETEDLS INVVVSSGGS
RNLLDALKSL SKILGSSFII DQSFFDEMLV LESLELGGNI LVDLTIQANI TTGSIDSLSY
DNVDVVVNLN RFEVVAFLQA PVLSLDLPLT LPAVGVGSTE EIVFSIFNGS FDLNFFVNLT
SPVDVLSLFS GGSDPVSLDY GGVLDARLPL EVGLAGSSIG VELALYDDNL FSDPLPTLSY
EIDVCSVVNV TKTLVQELKN QILAVIQQPL QNLDVPINLD KITDPLIEKV DSVLGNFTDE
IEHSLDATNC GGTENLSRLL QETTNSSFAS KFRDAISSVN EALVSVGIVF TAEVSPYFVS
ETMTAGISTT LTVSVEQTAA DIIGLVEDFF ADATNSSGVS YLGIDNSDAA AGASLDLNAL
LDDTVISVGV DVTFAIELDL KEIQSVITSG TPVDEALEEG IGLHITTWGA YASLIVDPIN
LELTLFGQTL GIRNSAIALS AGLRSKGAFF ASAKDILDGT ADTSSLIPDL TVPLSAEVVF
DFDVPGVDGV TISPILKLDS TNLLDDFSID FDVDLETFLS EGLFGDNRLD IVLDNVTELL
GTIATFSPDL QVGSTPSAVS GFFQIIDEFK DFAGALTNFT DLFNEVNALV PSEIRSVVRQ
ASRLSTDGGC VEASTTFSTY AYDLLESEGL LNVSTTLSTF RVCEYLPQLQ KALNYSVTAS
SSVSYLDLVV IPSALNTTLQ SYFGEELDFG GSFVSIAMCQ VHIWLDVFSI AILTASPFFY
NSQLLENFGI LSTRRLMNFI HKFLLSSGDG ETAGRRLKSS TERSQVTKRG SVMRAVRNSM
LPLVESPNPS RRLQTTQDEP LFGLELNDLL SIYLDFNIGD GQKTLMLGLN FHFFSDESAV
DDITEMLQDF MNDAIGDKGG DDLGGFSFAE QAATLASSLI ESIVMDVEVY IDVTFGLDLN
LLFNSTAPAA ERFPSPFLQI NQLDLTGTFG INEWSAKLDL VDKACRMRLS ILSYSWMLLL
IICSICFQKF RLPICMISTP SEFLALITPS SSEVELHGSL FVNLPVFIIV DDFGFGARVV
YNDTDVFDSI IPSPVFSKDV LISIELIRKA AAELRDVTGF LSTFGPLEAD IPLIKKSVND
VIAGTDRTLA DLFDLTEWAQ NLEGKITQSE SPSFAPSGSF RPSDLPSYSP SYTPSYHPTE
SVRPSDDPSK SPSLKPSLSG RPSSSSKPSL RPSFSSRPSS SSAPSFISSS SPSISFVPST
SPPTVMPVES STSSPSVSFS PSLSPSLQPT KGRSSQYIAL SELKNEIRAA FQSITKPDLS
TAELPPLPDT SIFNVSRPTT AVCSGNDKAL SIDIEEGSGG ALVITLCSLL EFEIHSSFDA
EGLLDLVEEM SVDLSISGDF SIKGALTFGG RITVNSISNA VIELDPITAQ LAVDSGLDAT
VSLGLIEGIV EANAKLKGRV QLAYCPSCGG VYDDGFNRVS QTSSFYFNRS IGYELGGEVS
GMLMASTSCA IAAFFGVRTN SPNIPGLEES NGLTMNISDS DVFDDVSPII VLPNGQAFLD
SIKFSPQSAV NMLRLLDGLI AGASSNAAFN ARIPLLDTSF NKVIIVAKMF TDKLYEFFVR
CEEFDDRGVK SLSIAQSSDN VTIINETKTF ELYMIKDDLD VNPIPENAQL IKNQALEEGN
GLCSITIGTY EDDNNLFLSD IVDSINDNSS CGIIACRNTG CDACDAEECL ACDTTDCDAK
DDIQEYRNCA CDVVVALDYE DKLVFRTVSF RNETNNEKND IKLIAIFDRF ETDTKVLADD
HFGLPLNSPA TPAIVPRFAT LAELTDSIGQ VITSFTGLGT TITAAYNPAA SSEEPGCLMF
GIAFDQEFGP LGISFRSSLE LGDLAEISVD EASLSIEGLI SISTEFGVIF DSDDTESLKM
TGTLSARNCS SGDSSFEFGI KLDGEEATNV TMSSCIDGAQ ARVDAIEAAV QALFINGEVG
VSLVGDDSIV FAFDPSYSKV EMIIAEAYDG NIYGLLNDTK KKTPFQFAAG YTEIGASFGI
RGDAELSARV GGSVEVGADI SCALGGSVQI SIGKSGVLLP VNQFLSKLKN RGDTNSSFYD
PNFAQAYVSL TEASFDASVE VREPLELSAP SVKGYLVEPF VLDLFDIAAI RSTTPNVALS
IPNIGDFSNL SFADAIKILQ FALDFLVGDE EGDSVESCSG GLLGNEVLVD AVDKLVNECA
ECQDDSAVKS PFSALEMKLQ NLLQDGVGGT PGVAITTAST DVRSIIELDV TLAWSFEEVN
QLNIDLASIL DGLDLDEDIV EFAKGILAFD GQALTTIEGN LSLTLGLGLE YDKQKKDKNI
YIKGNTGLEV GFSAEVNLEF DATIGPLPAF VEVLATIDNL GELLQIKFGL DERKNYYLSP
DRTLARTGYE VVSSVTLAAK KQEGLSIIYT ASVVETPSLL TILLMDPAAI VDAVDDVFKA
ANDLSFGRTG IVTRFNLPFV GGAVSRALKA GSSDNFLERA RRLVVGTMSE VIDTYDDEES
TGTVADLVAD ILSDLLDDVL RGNINVTYYE HVGNATVGSD VYDESKTIKS LMWTIPFGQS
IDITLPPLDF QLPHESLPLQ LRVDSEVPML TLSWDFKLSF DFYLNVAEID AKLLYFLNLY
MENAVIEFGA GIFVDIDKEA ALGKADGVNS LLYGRVTRDM FRNKIKNKKN LFQICAAAAA
AVDVEKVTIQ LDVPIPNFDE VKPWIPSLNI GHNASSSGLQ SPSHTFLAKL ITQAIVKKEV
STATTSISRG RSMKEADRRR LTDSIPSDAH RGLRMLCADE LIETEIICDL GQTEFACANM
TDIRLDVTKL QGLVNPIIGF LVNEDGKSGA FDGVGSTLEE LDKRLPGVSD LAGKVFVGPE
SGVDQARLVL KLYRSLKSLS ELFDDDDPNG ILLADYCSFK PGQDKDCAGG LFEEDDGLRR
LQFAKEMDET FPTYDAGGNK MTPVHRLLGA CPSSFSGPDC EGTCSCAGAA LAKCKAKKLK
CKAQNTEGLR VPFMEDLTSV FGLLSGNDIE LLEFQPPPLE FVFDMSISAV LYTPPTVELV
ISFGVSLTVE YSLVLDTKGI REAVKEKNPL KALNSFGIRD VIDEVDSPLI VFEASVSAAI
EVSAAIVKVG ASGGITVTVE IDLFDPYPDT SGGIVRPFEL LAMGSSPLSW FEVTLTITLN
LSIYIKVGIY IGIIDITVFK LQKDFNIVIF GPQKFLPPGF DPVGEVDSVS GVLTLLSSDL
ICESKSGTAG EEEVQCWDAN ASLKTIVAPD SSLFKRNLSE ENHASIGARK LSTISGQEFR
CTQSPIDLGD YDEDVLINWE DCQIESLELI IARAQIIGYG VITFDASTQT TIEFSLPAPI
QDLLTTFVSG CTAERILNGH TNLVIYGNEV GEDCRIVAEG TNQADATLTV EFGSDDDCGN
GYLVEVDEGT IRIDGNDIVQ FGSPFKDIRL IMSRYCNDTV LIKKTYSDAS SIEIIGTEGY
NVIELGDPLY PLEEQIFANI IIDGSKDSLT IHDTSSVTTK PDIELRPRYI YNILQNPNNT
ISYIGIVYLG LDLGKTAAGL TVVSTVPDIS VTITTQDDDD VISVVNVQGD LTVISGNGND
KINVTSTKGN LHVISGIGTH EIIISETAGI VDIELGNGSS HSIIAHDTGD SLSVAVGTGD
SMIDAQDTSN GVDITTGDVT VDEVVVGVLR TAQGGVSVTT GSGTHYVDIL LTESGDATVT
SGGGIRNEIT ILETNGGNAI VDSGIGPHII LVQDTSNNVS IQTAGGDNAC PLTSDVNECG
CSQTNQTEYR GWINETAGGL TCQAWDSQHP HSHDTTPQDH PNSGLEGNYC RNPNNRDGGS
WCFTTSTREW DYCNVPKCIY DEVLVVNAGG ALNVSLTGPG DDNVTVDHVE GDQKIITDAG
DDFILIVHNG IDSHLFINGG SGDDIFQIDY LGGDGEVYGM AGDDLLLLDG RNESDVSINT
FDGTSLDWDG GEGDDRIEMY LVSAGTTNLN VVGDNNDVNV LVARCSNVAC TVLSRETFLA
NIHRPEDKNT TLERINIDST ASITSLLLYL NGGENSVHFD DTIAVTDVFG GDDNDSFYFG
QMYNDERNAT YGVSTNDPIQ TILTTKGYLS DGCSHPVTVN GGHGDDVFDV LRNKCILDLN
GESDDDSFTV RSFIAAVIAD DGSLLDPELG NVTLKGGEDG NDKFQVAVGG TDEGFETPPE
YLVNSLVDID GGTGSNNLTV VGTEAGDKYV IQDGKVFGGG LTLKYTNIAY VDVSGEEGDD
VIVVLSTNPS VLLSLYGSLG SDTFIITPQD VDPVVSKNLR GHRGILEHTV VSDTDSEYDG
FVVRGVQADV MDNDGDYGWV YTVDQGGFHL MSEDSMGDFS FFLFPTTVPN DDVYVNIVAP
AALDEKRYVL LNENEDAEIL YWAAGSMSPQ EVRVTYNVEV RKLAITEVNL LLKLLVDVDG
DKTKDERFKM TEQSVLPIDI TLIPSINNTA GARSVTVKES IDGTFVAEGP NGFNSTYDVY
LRPCSEEMLD AIEVSMIATV ANQIEISPSV LIGSDFGSEC KATVHVSAVD DEWAEGDHYS
AILHEVKNKT SGEDIMLADN SPLLASNLLV NIYDDDTAGI IIRESNKITS TVELDDDDKD
VVGNATYYED EYFLRLTKEP NGTVEIQVDS IAVATDYDGY FTPDGRNFTA RKQVLVNGQE
ATTVVFDSSN WFDEVEIRVT AINDDIEEGV DYLHFASQPS NLGLCQGPIL ISGGSSPYIR
PLGNPVMLPD ESNPDDFIVP PGVVIDDTNA LVWEDHQIDT VVFNHLNAQG NLPAVGTLLP
SQFIGIGMVQ DLLIKTNGPY SGIIYNGIEV LTFNFGNEVD DIYVNETSEA IHLMNLGAGD
DNVTIRSISG PLIINGDGGR DIVVVSSDEQ KLDRINAFLA FDGGQDDDVD ELVLDNSADE
DADDVLNVTR HIVQVESMEL NEVNTTEDAD KNPILPRNSY VITLRNATGG SFNLSLEDYS
TESTDLLEVF IPYPASAADI ESAIDSMLIP NSKSCGQQET SVCSPSARVW QLGSSQTYAI
FFMGERLNAN ISLDLNTDEL ESFYGEMFRN ETNDILGMNS DVVYTHVDVL RIEMGHQEIV
SNIRGTTAIK TYITTQEGDD KFFVASDANE NTTTARTVEV SFGTLDYFEG DLHLEGQSGR
HRLFISDRNS TTPKGIGADG PAVLSSSALE HLADNLGNIY YDANGGNWFD DLTLWLGEGG
DEINITSLPT VGVPSRTTTS LHTGWGNDLV YVNLDASDND GALFVANGQD GDDVLDATNS
SLPVVLFGDG GDDILRGGNA SDVLIGDYGI VLWIDDDGVV VARAGGGGYG DFTDDEERNI
YRVKSLYPFP AFTNNYDSGS DRIDGNGNRD VIFGSGGLLD EIHGNDGEDL IVTDYGVIEF
DFKAPNLEGV LSIESRDCNE PVDGRNVAYG GSQDDVIIGG SASNDTIYGN EGNDLATGDC
ASILFDEKFH VVNITSTFVE LGSSDNITMG NGTNVAIGGY RDDFILGGDD RDILVGDNAE
ILFYESKSLF EQSIWNIPKS IRSISCEYSG EDHIYAGGGL VDYVIAGGLD DYVEGNDGPD
LVFGDHATIL LSNETQFELV SATTLDPFCT PGNDTIYLGQ GHDIGFGGAF GDEIDGGEGQ
DLILGDFGKY DATVQFLPNQ FFESIIDSPE MAGPDTLIGG DDDDILIGQE DRDHIEGNEG
NDDLIGGHEK RHGEDTGDYI DGGSGADCVL GENGQILREV ASYDTTFPWI VHVWKAYPLP
FNSEPIRDIR RYDDIDNVSG DDEIYGGPGN DILHGMRGDD YIDGGEGDDE IYGELGSDHL
FGGSGDDIVI GDIGYAIRRY SGLEPIVKSN DVWHKDIVLE EIGNITSVQT ISQKFNASSL
NAEDVADASL IFVANAYEED GKKYMDSNGV WLSDMFTFNL EQAYNDTCDG GEGNDVIIGQ
RGDDELISGG GNNLVIGDAG FNTITSNADF ARIYQIYRSM ESPAGSNYAP DAEDYGFAFM
VDFELYPNPY RNIDSLTSII GEQNQIVTID DVLEGTNVVR DMLGVSGIST NSSFCLQPMF
RVLPGFLTDT PLHGNDRQND FIVGDDIRGF NVMDLTELSD VQDARQQLDN SIADLSIRLS
TLGYDTWFYS QYTNGSQHLG DPNLKVGCDI ITTSADSNSF ITGDILTLIG RSFQGTYFSK
PNAQIPLVLE RIFDVERTLV SLHMSLNEIH IDLLKRAQRD ISGDVTQDQV ATHSLSLGND
DIFSNGTDII VGDSSTFFVQ LDSPFEDFIF ETLNRSSVDI GQLNSDLRDI TTLRADETNS
YVESVLLPTT PLTKSEISSL PYADIPINIT VGSDRIILGE KDIIAVGDFA SVGIIYSQEG
SVSDLSSLSK YSDSIEMTRK KPSVSSFLYR LRSYDLKFYH ARYKTKVPDP FYHGDYFEAT
SDKNIIFGDY LTAVAYDFET SPGMVVDSKA DFYGTYLNAE WAQTMGGDTI NATSGKPVWD
GQKGKDVVHG NVNSNAKTDG FVTDGMKRML ADPSLAKQIW KDLYNYPVPY NTFKDPQQRS
ICNPSNSYIP SHTLSIYLVP LPTGEIEQTP RTDWASSTAG DSVSTSSQKK NGKNNIFLRK
RAL
//
