ID   B6B9V8_9RHOB            Unreviewed;       344 AA.
AC   B6B9V8;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Cobalamin biosynthesis protein CobW {ECO:0000313|EMBL:EDZ47039.1};
GN   Name=cobW {ECO:0000313|EMBL:EDZ47039.1};
GN   ORFNames=RBY4I_2257 {ECO:0000313|EMBL:EDZ47039.1};
OS   Rhodobacterales bacterium Y4I.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales.
OX   NCBI_TaxID=439496 {ECO:0000313|EMBL:EDZ47039.1, ECO:0000313|Proteomes:UP000005133};
RN   [1] {ECO:0000313|EMBL:EDZ47039.1, ECO:0000313|Proteomes:UP000005133}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y4I {ECO:0000313|EMBL:EDZ47039.1,
RC   ECO:0000313|Proteomes:UP000005133};
RA   Moran M.A., Buchan A., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR   EMBL; DS995281; EDZ47039.1; -; Genomic_DNA.
DR   AlphaFoldDB; B6B9V8; -.
DR   STRING; 439496.RBY4I_2257; -.
DR   eggNOG; COG0523; Bacteria.
DR   HOGENOM; CLU_017452_1_0_5; -.
DR   OrthoDB; 9808822at2; -.
DR   Proteomes; UP000005133; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR012824; CobW.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR02475; CobW; 1.
DR   PANTHER; PTHR13748; COBW-RELATED; 1.
DR   PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005133}.
FT   DOMAIN          253..342
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00833"
SQ   SEQUENCE   344 AA;  37175 MW;  E3A1805F6BB822D9 CRC64;
     MSDLNKIPVT VITGFLGAGK TTLIRHLMQN PQGKRLAVVV NEFGTAGVDG DILKSCADEN
     CPAENIMELA NGCICCTVAD DFIPTIEQLM NLPEKPDHIV IETSGLALPK PLLKAFDWPA
     IRSRITVDGV IALADAEAVA KGQFAPDLDA VQAQREADGS IDHETPLSEV FEDQISCADI
     VLLSKADLAG DAGVEKARAV IEAEAPRKLP ILPMSEGVID PRIILGLNAA AEDDLEARPS
     HHDGHHDHEH DDFESIVVEM GEVSDPEALQ NAIVKLARER NILRVKGYVA VEGKPMRMLV
     QAVGERLRAQ YDQPWGAQPR KTALVVIAEH DDIDEQAIRA ELGA
//