ID B6CIX0_HBV Unreviewed; 212 AA.
AC B6CIX0;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
DE Flags: Fragment;
GN Name=C {ECO:0000256|RuleBase:RU361253};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ABY54111.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ABY54111.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S-IDU6 {ECO:0000313|EMBL:ABY54111.1};
RX PubMed=18507755; DOI=10.1111/j.1365-2893.2008.00997.x;
RA Trinks J., Cuestas M.L., Tanaka Y., Mathet V.L., Minassian M.L.,
RA Rivero C.W., Benetucci J.A., Gimenez E.D., Segura M., Bobillo M.C.,
RA Corach D., Ghiringhelli P.D., Sanchez D.O., Avila M.M., Peralta L.A.,
RA Kurbanov F., Weissenbacher M.C., Simmonds P., Mizokami M., Oubina J.R.;
RT "Two simultaneous hepatitis B virus epidemics among injecting drug users
RT and men who have sex with men in Buenos Aires, Argentina: characterization
RT of the first D/A recombinant from the American continent.";
RL J. Viral Hepat. 15:827-838(2008).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells.
CC {ECO:0000256|RuleBase:RU361253}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000256|RuleBase:RU361253}.
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DR EMBL; EU185765; ABY54111.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR HAMAP; MF_04076; HBV_HBEAG; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 3.
DR SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE 3: Inferred from homology;
KW Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT DOMAIN 1..27
FT /note="Hepatitis B virus capsid N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08290"
FT REGION 178..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..204
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 212
FT /evidence="ECO:0000313|EMBL:ABY54111.1"
SQ SEQUENCE 212 AA; 24425 MW; 182D3A6123CF5A68 CRC64;
MQLFHLCLII SCTCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPT DFFPSVRDLL
DTASALYREA LESPEHCSPH HTALRQAILC WGELMTLATW VGNNLQDPAS RDLVVNYVNT
NMGLKIRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS MLPETAVVRR
RDRGRSPRRR TPSPRRRRSQ SPRRRRSQSR ES
//
