ID B6DS95_STRPU Unreviewed; 521 AA.
AC B6DS95;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096};
DE EC=2.7.10.2 {ECO:0000256|RuleBase:RU362096};
GN Name=SFK7 {ECO:0000313|EMBL:ACI14304.1};
OS Strongylocentrotus purpuratus (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668 {ECO:0000313|EMBL:ACI14304.1};
RN [1] {ECO:0000313|EMBL:ACI14304.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19150445; DOI=10.1016/j.ydbio.2008.12.032;
RA Townley I.K., Schuyler E., Parker-Gur M., Foltz K.R.;
RT "Expression of multiple Src family kinases in sea urchin eggs and their
RT function in Ca2+ release at fertilization.";
RL Dev. Biol. 327:465-477(2009).
RN [2] {ECO:0000313|Proteomes:UP000007110}
RP NUCLEOTIDE SEQUENCE.
RA Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA Muzny D.M., Worley K.C., Gibbs R.A.;
RT "Genome sequencing for Strongylocentrotus purpuratus.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:NP_001135851}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149,
CC ECO:0000256|RuleBase:RU362096};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000256|RuleBase:RU362096}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ161084; ACI14304.1; -; mRNA.
DR RefSeq; NP_001135851.1; NM_001142379.1.
DR AlphaFoldDB; B6DS95; -.
DR EnsemblMetazoa; NM_001142379; NP_001135851; GeneID_577286.
DR GeneID; 577286; -.
DR KEGG; spu:577286; -.
DR CTD; 577286; -.
DR HOGENOM; CLU_000288_7_2_1; -.
DR InParanoid; B6DS95; -.
DR OMA; XWYFGKL; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd05034; PTKc_Src_like; 1.
DR CDD; cd09933; SH2_Src_family; 1.
DR CDD; cd11845; SH3_Src_like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24418:SF447; TYROSINE-PROTEIN KINASE SRC64B; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141,
KW ECO:0000256|RuleBase:RU362096};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362096};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|RuleBase:RU362096}.
FT DOMAIN 68..129
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 135..233
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 255..506
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 283
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 521 AA; 58917 MW; B49DE2DCB2E4B826 CRC64;
MGCLHSTTNA PASDHRSKQP DTSFNSPGTG YNNGGSRPDQ PFTNIATPSF DQGPQNAIQP
SQTHSAKKEV ISFIALYDYE ARSEDDLSFK KGEKLEILNN TDGDWWLARS PLTNKEGYIP
SNYIARVKSI DAEDWYYGKV GRKDAEKKLL APGLQKGTFI VRDGEANPGT FSLSVRDHDP
GKGEHIKHYR IRKLDNDSGY YITQRSQFQT LLELVHHYEQ SADGLCCSLS VPCPKENPIT
AGLGKDMWEI PRESLKLDAK LGSGQFGEVW KGLWNGNTEV AVKTLRPKTM TPAAFLAEAN
IMKTCRHENL VQLYAVCSDR EPIYIVTELM KHGSLLDYLK DGDGRHLKLP QLVDMGAQVA
SGMGYLERKN YVHRDLAARN VLVNTGNICK VADFGLARMI QDDEYCARQG AKFPIKWTSP
EAALYGRFTI KSDVWSFGIL LTELITYGRI PYPGMMNMEV LEQVERGYRM PRPHNCPDSL
YDMCMMKCWH KDSQQRPTFE FLHSFLDDYF VSTEPNYREA D
//
