ID B6GXA2_PENRW Unreviewed; 412 AA.
AC B6GXA2;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Pc12g00300 protein {ECO:0000313|EMBL:CAP79657.1};
GN ORFNames=Pc12g00300 {ECO:0000313|EMBL:CAP79657.1}, PCH_Pc12g00300
GN {ECO:0000313|EMBL:CAP79657.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP79657.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP79657.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; AM920427; CAP79657.1; -; Genomic_DNA.
DR RefSeq; XP_002556934.1; XM_002556888.1.
DR AlphaFoldDB; B6GXA2; -.
DR STRING; 500485.B6GXA2; -.
DR GeneID; 8308732; -.
DR KEGG; pcs:Pc12g00300; -.
DR VEuPathDB; FungiDB:PCH_Pc12g00300; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR OMA; STAHWFD; -.
DR OrthoDB; 1133at2759; -.
DR BioCyc; PCHR:PC12G00300-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c12.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 80..318
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 412 AA; 45601 MW; 33554FF0CC650FC9 CRC64;
MSAKRRTLEL GNVLVVGGCG FLGWHIVDHL LNFPSETDPS YALPKPVGDA RFEYPTLGSR
YPDYHSTVSV VDLRTTNNRL PGAKYYDGDI TSVDSMLEVF RAVKPDLVIH TASPSMIEGN
KPLLHKVNVE GTRTLLEVAG GEHGDWGGKC KAFVYTSSSS VVHDTQSDLK NVNEEWPYIR
GPAQKEYYSE TKADAEELVL KYNKKSPNEM LTAAIRPAGI HGEKDTTVTH KILEHGSQAS
DRVLRMQLGE NDNLFDFTYV GNVAYGHLLA AHRLLASYDL VAAGKGGPLD YERVDGEAFN
ITNDSPVYFW DVTRAMWALI NRVVEPEQVW ALPEGLLETV GGIAETVMGL FGKTPRLTAR
TVRYSCMTRY YSTEKAKRRL AYLPVVPLDE GIARAVGYIV AQKQADAGKK TL
//
