ID B6H1Y4_PENRW Unreviewed; 850 AA.
AC B6H1Y4;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Pc13g03370 protein {ECO:0000313|EMBL:CAP91406.1};
GN ORFNames=Pc13g03370 {ECO:0000313|EMBL:CAP91406.1}, PCH_Pc13g03370
GN {ECO:0000313|EMBL:CAP91406.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91406.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP91406.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- SIMILARITY: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
CC {ECO:0000256|ARBA:ARBA00010193}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM920428; CAP91406.1; -; Genomic_DNA.
DR RefSeq; XP_002558775.1; XM_002558729.1.
DR AlphaFoldDB; B6H1Y4; -.
DR STRING; 500485.B6H1Y4; -.
DR MEROPS; C02.008; -.
DR GeneID; 8313437; -.
DR KEGG; pcs:Pc13g03370; -.
DR VEuPathDB; FungiDB:PCH_Pc13g03370; -.
DR eggNOG; KOG0045; Eukaryota.
DR HOGENOM; CLU_006770_1_0_1; -.
DR OMA; GDYRRGC; -.
DR OrthoDB; 230045at2759; -.
DR BioCyc; PCHR:PC13G03370-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c13.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00745; MIT; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT DOMAIN 126..437
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 197
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 364
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 384
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 850 AA; 93875 MW; FE529D9B536C5C39 CRC64;
MSRPASTQSL ISQARSAEEA IAAATSKKAA LEAAINAAEH YMKALRLAPA DDKKLLDAKC
KELISKAEKI KAATDWQSAA RAGPQKAFPS LRPPASTRKL TTREEIIILE GAKLNGYIFP
PWSRAPPQDE FVYKGQLFTD TPDLHLSECQ REIFAGWKRP HDLLQTMNTA KQPYDIINPA
MSASGETDLV QDVLTDCSVV ASLCATTARS ERGLGQHASP TLYPCSEDKN PILSHSGKYI
FRFYFNGSFR KVVIDDRLPS SKTTRSLHVI DRNNSNFLWP ALVEKAYLKV RGGYDFPGSN
SGTDLWVLTG WIPEQVFLHH DDSTSDEIWG RLYSAFWHGD VVLTIGTGKL TELEQQGLGL
VSEHDYAILD LKEVQGRRQF LLKNPWAGAE PHIQSSLTAD LGSLGLNDKP PLSPGTFWMD
CEQVLQNFEN LYLNWNPGLF KYREDIHFTW DLSHGRVIAG CFVKNPQFSI SSDSGGTVWL
LLGKHFKTDH QEFDTGESEN ETGFISIYIF QADGRRVSLS DGALHRGPYV DSPNTLMRLE
MPPKSTYTAV VSEQSLPSSA QNFTLSAFST APVAVAPSLD KYLCLTKASG SWTAMTAGGN
AESPRYHSNP QFSIRISEPT DVSILLETTE AELATHVKIF WSNGQRVSRV RSRDIIADSG
DYRRGCALAE TKSLDKGTYT IVCSTFAPDQ FGRFTLWISS TIPCVVQPLV SESAGRRAVL
SEVGVLSPGK DRMLASLRVS RLTRIRLIAR NKRSTVGLRA VAPSPVLMTV ELGQGPYKEI
LATSEDGAHS DAASGVRVED FDLLPSAESR RVWIVIERIG GPGGQVEDHF EVEALAEERV
EIGKWVIEDE
//
