ID B6H4F6_PENRW Unreviewed; 2526 AA.
AC B6H4F6;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Pc13g08690 protein {ECO:0000313|EMBL:CAP91938.1};
GN ORFNames=Pc13g08690 {ECO:0000313|EMBL:CAP91938.1}, PCH_Pc13g08690
GN {ECO:0000313|EMBL:CAP91938.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91938.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP91938.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
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DR EMBL; AM920428; CAP91938.1; -; Genomic_DNA.
DR RefSeq; XP_002559294.1; XM_002559248.1.
DR STRING; 500485.B6H4F6; -.
DR GeneID; 8308642; -.
DR KEGG; pcs:Pc13g08690; -.
DR VEuPathDB; FungiDB:PCH_Pc13g08690; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR OMA; QWHGMGK; -.
DR OrthoDB; 5396558at2759; -.
DR BioCyc; PCHR:PC13G08690-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c13.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901336; P:lactone biosynthetic process; IEA:UniProt.
DR GO; GO:0030639; P:polyketide biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF13; POLYKETIDE SYNTHASE 1; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 36..460
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2426..2503
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2526 AA; 274619 MW; D56A9A44B776025C CRC64;
MRLQQPSGTG TPVIESANGS LQTPSDIPDN ATGDVPKRTA IIGMSCRLPG DVSTADEFWD
LCSRGRSAWS PIPKTRFNAD SFYHPDPDRP GSFNPVGAHF LTEDIGLFDA PFFNITLQEA
RSMDPQQRIF LECVYEALEN AGITSHEITG QKVGVFAGGS YPDYEINNTR DATAIPMYAS
TGTAMSLQAN RVSYYFDLNG PSVTVDTACS SSLSALHLAC QSIRNGECSM AIVGGCHLNI
TPEAFIAMTR SRLLSDTGRS YAFDHRGTGF GRGEGAGCII LKSLEDAEAA GDVIRSVIIN
SGLNQDGRTR GIAMPNGEAQ EALIRQVYEE ARIDPSLTAF VEAHGTGTKV GDPLEATALN
AVFGKGRTPR QPLLVGSVKS NIGHLEGTSG VVSVIKTALA LERGFVPPNC NFEKANDEIP
MEKWNMKVPK KLMPWPRGKP YASVNNFGFG GTNAHVILQR GPRHQGDLAQ NDDPLKRKLY
VVSAYDKQAA LHLGKSVATY LDLFPVVFDD SAMGNLAYTL GQRRTFLPWR LASSAVLSQE
LTASLDNNAV PVRSSKEPTV GFVFTGQGAQ WHGMGKELLS TYPVFKQTMR DVDTCLKSLG
ATFSIIDELL LTDPSASSIS AAYMSQPACT AVQLALVDLL SSWGIHPKAV VGHSSGEIAA
AYAAGILNLE ECVRVAYSRG VAANLVANDK SIKGGMLAVG ASASDIQQIL DAMRGNRAVI
ACVNSDSSVT LSGDADVITD LQAALDKEGI FTRRLQVDVA YHSHHMKIVS QEYRCLIGKI
APRDSEVPFH STVYGKLVPG RTLNASYWVD NLVSRVEFVE SLKSLVTDEQ ANTPITTLVE
IGPHPALKTP VQDIAQTYAP NSNVQYLHTL KRKVDDIEAV QNLAGSLFTQ GMNLNFQAIN
FPNVKTTTRK PAVLTNLPRY PWNHSERYWS SSRVADNHFR GQFARSDILG SLCMENVDFE
PRWRNIIRAE DHPWIREHRV YGTTVYPMTG FLAMAMEAIS QHAQLHHVTP GKIDIRDIFI
NRVLTIPDNS SVETMLSLKP SRSEAPSKSV LGWHEFKVFS WAEGRGWDQH CNGFIMVQEA
KDVNPVDGSR QQLEKTARFT QQALNMRNSC KLPVDSTFLY ENIAKGGVHY GPLFRGLTDI
SVSRDHLAIA TLRIPDTKAA MPHGHETPCI VHPVTLDLCS QVTWVLHGYG EPGPQITHVP
SHVKQISISL CQEISAGAVL QLYGSMSGNE SASNPDTNRI FATASNNPAN PLIDINGITL
VPVSNDIKGS KDTSPDQICY KMQYEPCFDF LSAEDYRQLP RPETDTAQGM KRMQRLEAVA
EHYLTQMVNS VTEDEISTFE PHHQKFYRWA QNTCQKAGFK DPLPLDVLEQ NRTVNGAGEL
AFRVGELLPQ ILRGKVDALT VLLEDDGIGR YYSDLDSLRE AYANVSVCVD KMAHQNPTLN
IIEIGAGTGG ATLPILQRLG GGEGGSTPRF GHYIYTDISP AFFEKAKTKF ESWGNLMTYQ
ALDVSDDPTA QGFSNGTYDV VVACNVLHAT PDISQTMSNI RGLLKPGGKI ILIEETVPKA
IHFPFALLPG WWLANDKFRK DGPLLTVEGW SNVMKENDFS GVDLCIEDFP GASFQSGCLM
TSTANTPITG PANAGDVVVL GSDSIGSVSS LSLESGLRKI TGVEPITAAD SDEVDVTGKW
CIFLGGMDRS ILSHLTHEKF QTLQRLLSRA RGLLWVVRHS KTDLESLGAN MAIGLARTVR
SETVFCQKSQ LDQNDWEFVV RNGNVCVPRL IDNNALNLSV QQETPDAPPQ MQPFKQDRAL
RLAAGVGRGL DELYFTDDVS RNGALPEDHI EIQVHSTGLN FRDVLMAMGQ LQGDRLGQEC
SGVVTQVGAA VSDFKVGDRV CAMSPGSLST FTRCPASGSW VIPDDMPFEI AASIPAVFCT
AYYSLIDLGR LTKDESVLIH AAAGGVGQAA IIIAQSVGAN IFATVGSPEK KNFLMETYQL
KEDNIFFSRD MSFAEGIQHA TGGEGVDVAL NSLSGDALQA TFECVAPFGR FIELGKRDIT
TNSRLEMAHF NKNISFASVD LGIVREKRPQ LTKRLLRDAF KLFVDTNAQS RWSVTTLPIS
DVEIGFRALQ GGQVIGKMVV QVTDDSMVKV HPARRDENLL RADASYIIVG GTGGIGLDIA
SWLPEKGAKN LILVSRSGVK TETAGQTIQD LTRQGVNVEV CCCDVADQQS VEQNLVPLLA
RMPPARGDTL FEKLSFADHQ TVMMPRVHGI WNVQRALTTT KGSVDFFVNL SSAASFVGNM
GQSPYAASGT FMAALAQYPE TAKMRCSTID LPIVRGVGYL SDDQKREAIS KQLGTASVDA
TDIRGLVTAA IRDEFDLSCE GHCVAGFGAV KSTPASEQPF WVNDTKLSHL LRLSTLAGAG
ELAESAHNGT EISPGLAIRQ SKSREGAEAI VGAAVLNKIS SILMRPMEDL DPAAPITVYG
LDSLVAIEIR NWITRELEAN LQILEILTSE SVPALAETIL KKSGILTPDL KTEWCLDVVE
GRTGQE
//
