ID B6H8Z9_PENRW Unreviewed; 6064 AA.
AC B6H8Z9;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Pc16g04690 protein {ECO:0000313|EMBL:CAP93139.1};
GN ORFNames=Pc16g04690 {ECO:0000313|EMBL:CAP93139.1}, PCH_Pc16g04690
GN {ECO:0000313|EMBL:CAP93139.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP93139.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP93139.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
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DR EMBL; AM920431; CAP93139.1; -; Genomic_DNA.
DR RefSeq; XP_002560820.1; XM_002560774.1.
DR STRING; 500485.B6H8Z9; -.
DR GeneID; 8304562; -.
DR KEGG; pcs:Pc16g04690; -.
DR VEuPathDB; FungiDB:PCH_Pc16g04690; -.
DR eggNOG; KOG1176; Eukaryota.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_6_1; -.
DR OMA; YPCSRMQ; -.
DR OrthoDB; 2787863at2759; -.
DR BioCyc; PCHR:PC16G04690-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c16.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 4.
DR CDD; cd19542; CT_NRPS-like; 3.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 8.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 14.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 781..857
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3134..3210
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4236..4312
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5332..5408
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 6064 AA; 670028 MW; 258D6410F2A108D9 CRC64;
MAQSTKCYLP RFASTVDGPK RPVSMKTRPT AAQHAQLLTA WNEGRLDPIL RATWALLLHY
YIRSEDICFG YQHLEGDSRS PKSSVQRSTV NISTIRISIN DNDSLKAIVD KVRANSAIRQ
NNGSPEASEA YLPFNTIFML RTYDPPASPS KPILATAIPD ECQVRLHVKV LRGDISIFLE
WRKGDMSGEQ MKSIANIFEQ LLAKVLSAEN TAISQLNLFS ENDWQRIRKW NSTTPQLHDR
CIHEAIHDQM LSGPDREAVC AWDGSLTFAE LDHQASKLAC YLRMQGVGPE IRVALCFDKS
KWNIVAMLGV MKAGGAFVPL DPSHPTSRLQ GLIQSVEAPV VLCSQHLADK LRPIVKTLIP
LCADTLDPLS DPTDSVNLAS GVTSQNAAYV LFTSGSTGEP KGTLLEHRAF LSGAMVHGPG
LRIYRDSRCL QFAAHTFDAS LAETLTPLIH GACVCIPSEE ARLNDIVSTI NEMRVTQACF
TPSFIGFIEI ESVPGLESLV LAGEAMSQSQ LTTWSKIKLV NGYGPTEASV ASVLNSNVTP
DTDCKDIGLP IGVRAWLVNP DNHDELVPVG CPGELLLEGP PLARCYVNNP QKTNESFIYD
PAWTTLDPET GSNRRFYKTG DLARYNSDTG ALNYVGRKDT QVKVHGQRIE LGEIENQLSK
DSNVTHCSVF FPKTGFSKGR LAAVVSSTGL LAEQSDSDLE PLRLVPASKK AELVPGIRER
LSARLPTYMV PAVWLCVEAL PLLPSGKLDR KGISTWVAGM ESDPDLQNGT SAAIVDAEAS
QPANDREEAL AAVYSRVLNI PQNQLNLNES FLALGGDSIA AMTCIGLCKK RGFALSVQEL
LRSKSIRDLA TRAKTIDHLT TYEEAVDEPF SLSPIQSLHF GVRKEGQGHF NQGILTRLNK
PVDERTLRKA VETLVSRHSM LRARFTDTGF ATASSQHITR DIKGSYRWRM HTLANMNEVE
THVADSQSSI NCFSGPLLAV DYFLVKGRPN VLSMTAHHLV VDIVSWRIIL EDLEDIILNP
EKTGTSDGSL PFQTWCRLQN EHCNTLRAEH KVATDALAVP DFGYWGLKDT QTTYGDVDCA
SFEIDPAHTN AILLECHKAL GTEPIDLFLA AMLHSFGRAF PDRSLPTIYN EGHGREVWDP
SIDISHTVGW FTILHPIFVS AYKSDSPIDT LIQVKDLRRR VTDNGRADFT SRVLPAQGNQ
GSKHPHPFEM SFNYVGQHRD LQRKDGLFQL VDQMAGEAGQ GGGAADFGSD TPRFGLFEIS
AMVVAGKVRF NFSFNKFMQH QNRIHRWVSE CQELLVTLSE QLPTLEPRLT LSSFPMLSLT
YPTLDKLLNE KLPAMGIESP DFVEDIYPCS RMQQGILLGR KRDSSYYAVH DTFEIRATGS
GKPNLDRLVN AWQKVVSHHA MFRTIFVENL TPRDPFCQVV LKSYDATPVF LQSSGEKDVL
ATFDKEDPKD YSEPEPAYRF SICQTPTGRL FARIEISHAA MDGNSISIIL RDLQLAYAGR
LEESPQPLFK DYIQYMQDAP NEASISYWRS YLDQAKPCHF PALTDGQQSA KALRSIPVNF
GALDELQTVC EKRGITLANV FNAAWGLTLR AFCGSDDVSF SYMASLRDVS ADGVQWVVGP
VINLLICRMK VADDAKLSDV LHQIQNDYME SLPYRHTSLI EIQHALKLSD TNLFNSGVSY
RRLPSSKDAV SSEIECAEVG SIHDPAEFPV FINIEAMDTT ARIDLNYWTT NLSDSQAANV
ANTYLRCLEN VVSNIDCEIR QLNNLSEDNR AQIMAWNSKT HKPFEKCAHH VVQEMAKKRS
DALAVTAWDG NLTYSKLDQF SSRLAGYLVT FGVGPGTLIP ICFEKSIWNI VSTLAIMKAG
GGCIPVDTPE SLAAVENWIV DNAVQVALAS PEKAHVLEDA VPYVIPVSES LLEYLADEDL
NPVAQSSDVA YVAMTAGTSG PAKSVVLDHS TVMTRAEAFA TTMAIADVSR TLQFAPHTSD
AFIVEAFATF MWGGCICIPA DIDPLNLAAC INALHVNVAS ITPTAASFFS PKDVPGLRSI
ALGGEVVPQS VLDHWKTDDL QLQVLYGTCE SSAASFHVFC SQEEHEAALI GKSTSCVSWV
VDPSNHENLV PIGSVGELAL EGPVIASGYL DDQSVETSDF FENAPWLSGQ RGGRKHRLFK
TGDLVRYKSD GSLVFVGRKN DKSQSALASE LIQTQTRIDT FLEKKKCVVE SVQLQRGDMK
TNALVAFVVF SDTIPVTYGD RVLQSATPGM KDAMSSLHAS LSTSLPGSKV PSFYIPISSL
PLTVSGKLNR QALKFETQAL SSSALEAFDI KHWNGSKTGN RAARQASLSG PNIAFWKEYL
ADVEPCIFPA LSHEASANAR SIRTLNKQSA NIHAFSRLSG LPVETLFQFA WAVVLRWYTG
SDDVCFGYSA AASETKSEAD GVSTCRFLVQ NEQKLQETLQ KAKRDCETSA LNVAPLDAVK
HQLGLDNTTL FNTSLIYRTA SNLPKGSTRE PSTSSAYKIL VEAEVSHSYA EIHFTYSSDT
LSSFQVSHVM DMFDQVLDDL IAHNLRDRTI GDVNVLPERS VRRIRDWNAA SPPRVEKCAD
ELIQQQALLH PRAEAVCSWD KNFTYGQLEI VSSRLARHLS SLGVKPEAFV VLCFEKSAWA
VVAQLAVLKA GGAFVSIDPS HPDSRLKMLI DEIGTNLVLC SSSVHTKVSK LCTKSFAVCQ
TSISQLPDSP LALPGARPTP NNAAYAIFTS GTTGKPKATV VEHTALSTTA IAMIDGLHMN
STTRALQFSN YTFDVSILEI MMILMTGGCV CIPSEDERMN NLGGAIRRME ATYISAPPAI
VNTLEPKNVP SLKVIITGGE KMPANHIDRW ADRCVINAYG PSEATVVATV GVKVDWDGNR
VNDDPTSIGT SPNCRVWIVD PNNSNRLLPV GAVGELILEG SNIARGYLAN EEKTKASFFE
NPVWNRHSGL QGVFKRNDRM YRTGDLVRYN SDGSLAFISR KDTQIKFNGQ RIELEEIEQQ
CIRCLPEDSQ VAVDVVVPEE RTIAKGLAAF FTVHDPDSNG GSNDQFAPTV PGADPLLLPI
SMSNMDAIQK LKGSLPELLP QSMMPRLFFP IRNLPFTSSG KIDRRRLRAM VQTLSKDTLK
SYITLTTSDR REISSATGLE IKLVALVEKT LELEAGSVTV DDSFFGLGGD SLSAMNLVGA
AQAEGIALTV SGIFNSPILV DMAKSCVVSD GPAEVKKEDI KAFSLLPSGV YLENLMDEVT
DSCEVSKDLI SDIYPCSAVQ EGLLTLSIKH NGAYVAQPSF RLAAGIDVGK FKQAWQQTVS
DLEILRTRIV HTEAMNFAQV VLKDGPISWV EAESFDSLPN DFLHLPKQNG AALTGYAMVH
PRGSSDSYFV WSVHHALYDG WSIPLVFRKV EENYFSSQPK RAGTPYSLFI DYLAKKDMEE
SDAFWKSYLT DLSSTPFPHN KNAVPDAMRA GNTQYHNMKL SRTRNSVDFT IPVLMRAAWA
IVIATHTASG DVCFGETLSG RNIDLPGVAD IAGPVLTTVP TRVQVDNAMS TMQYLQKIHQ
STTEMIPHLH SGLQRIRQLN KDTSEGCNFQ NLLVIQPGDG ELDNKIWIDE KRETSEDFFT
HPLVVECGIT KTSISFTVHH DELVISGWHT KRLTEQFAHV LQQLIALPKN STSKLEDLEV
VSPEDKAEIG TWNERIPLTV ERTVQDFIRE KSEETPNAQA VCAWDGDITY REFWNLASGF
ANYLVSRGVG PEVFVPVCLD KSAWAMVTLI SILIAGGGYV PLDPSHPTSR HEEILADVGA
NMILCTPNYT NRYSRVVKTV IPISKETIKA YGALKSSSRR RTDVKPTNMA YALFTSGSTG
RAKGIIVEHR NVVSSIMAFA PWVRMDETSR VFQFASLTFD AAVMETLAIL MLGGTICVPS
EDDRLNDVAG AIRRLNVTWT FLTPSIASII EPSSVPSLKH LVCGGEKMSN EVITKWANSV
HLMNGYGPTE TCVFAVIDNA VATNRDPGRI GYGIPSTLTW IVDPDNHDRL TPLGAVGELA
LEGAPLAREY LKNPEKNAEA FTSDPAWIKD FTPAIPGPRR IYKTGDLCYY NPDGSIQYIS
RKDHQVKLHG QRMELGEIEH RLSEDALTRH AVVVLPKNGP LKQRLVTVMS LNSVAADTKL
ISDKPCELVD ENELERHAYN ELVEVQKNLE NQLPIYMVPQ TWALIKKLPM LVSGKLDRKK
ITAWVEDIDD ASYERIMADY DRIKRGKIEE KPQEKEEKHG SLSIIREIFA QVLNISLQKV
NVDRSFVSLG GDSITGMAVI SRARKQGLVV TLHDILQSRS LKELAQTASS KAPVSQREEK
SGDGFALSPV QRLYFQSSDS FKGAARFNQS MTVRIARRCE GEVLKRAVKA VIGQHAMFRA
RFSTSSDGTW QQKTAAVGSL QIPDRTFSNS TSQEVDESFQ FRVHSVADIR GMVPKIAESQ
NCLDPLNGPI LAADLFNLRT GGQVLFLVAH HLCIDMVSWR IVLQDLEELV VSGSLSLDKA
LSFQSWCAMQ TERAKIQDAT ISLPFTPEKP SLLYWGMQGS PNVYGDIKME SFMLSEDTTK
FILDGCHSVF RTDTVDILLS AIIYSFGRTF TDRRVPTIYN EGHGREAWEA DIDLSRTVGW
FTTMAPLLVD SEARALNDII KRVKDTRRKI ADNGRPYFAK NLLQDQGSDF PVPLEILFNY
LGKMQQLERA DSLFHHHGSV FDSSDFAVAG DMGPQTARFA LFEVSAIVIK ERLNVAFTYN
NKMQHQGSIR RWILQCKQTL DKDILTLKTA TPEPTLSDYP LLPINYHGLQ MLTASTFRKA
GIRNKDDVED IYPCSPMQEG LLLSQLRDPN AYMFHTVFEI KDGKSGKVDA EGVARAWQAL
VDRHPVLRTI FVDSNYTGGS FDQLVLKNLS DNILRVQCQD SQVEEKLAAI SLRDRNAMRQ
AKLSHQLTVC KTNTGRVILK LEMNHAIIDG GSVDVLLRDL TLAYERKIAE GSGPLFSDYI
KLIRTQSHSD ALSHWKEYLG GVHPCHLAPS AVFEAKRELK GVKMNFQRFP ELLKFCERSS
VTLANLTLSA WAIVLRQFVG SDDVCFGYLS AGRDAPVDGI QDMVGIFINM LCCRVQFSDQ
QTLTDVSKSV QDDYIRCIPH QSCSLASIQH ELGWQGQSLF NTTLSIQNHS VAGGPKDKGL
SFDLQHAHDP SEYAVTVNVE IARGQEGILL RYWNDIVSDE EAQSLADTIA KVFTGFIESP
AATLSQSTFA SEAEPESVDW DRSQTTLADK AKSTGEAIDS SAMQKIIDDR VHEIIGQMLR
EGKLTVPPIR TEGLSSYGGH TDTIADSPYQ LGIQGADDSG VCSATSRSSE DGMSVDVERK
LWNLWSTALG LSPNVVRHQD SFFKLGGDSI TAMKMVSAAR EEGLVLTVAD VFNNPVFEDM
LTTVRAANVT QQMLNADLKS GGHKEVDSDL LNITPTTLGP SPSTESLEVL KPSCVDDAAV
QRGICPKVGV FKGGIADVLP VTDFQAMSLT ATLFKSRWML NYFYLEGNGP LDLRRLRESC
LKVVAAFDIL RTVFVCFHDQ FFQVVLRKIR PSIFVYETDR ALDEFTMTLQ QRDREYGPRE
GEQYVQFYVV KKKNSDQHRI MIRLSHTQYD GVCLPKIMAA IKHGYEGTPL PPVTPFAGYL
RQLPGTITPD HYRHWTDLLK GSHMTQVVRR RGTSMFQNVG AFTEIHRKIE ISPTALGNVT
IATVMQAAWA LALAKLSAQS DVIFGLTISG RNATVPGIES TVGPCVNVIP VRVKFDEKWT
GVDLFRYLQD QQVSNMPFES LGFREIIKQC TDWPDWTYFT TSVFHQNVDY EGNMQLDNNK
YRMGGVGVND NLADLTMVSR PSGERGLDVT LGYSEKGPVM PSFASKVLDM ACEIAQSLVA
NPTASLPSAS MLRSLPPQTI DDQPRPTDEH FLSAHLKSRS IAELLVHSDI LSRSWHQVLP
SRTTTGPVDP EADKPTHQSA FQLDSSFFDL GGDVFNLAQL TWLLEQEGLK VRLEDLIEHP
SFLGQMAVLA LHNAKHQEDM PTELLATGAA PPDPVARIEK KKTWSKAMTI ARKLTGRNTV
TSRA
//
