ID B6HBY9_PENRW Unreviewed; 1240 AA.
AC B6HBY9;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000256|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000256|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000256|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000256|HAMAP-Rule:MF_03013};
GN ORFNames=Pc18g00730 {ECO:0000313|EMBL:CAP94297.1}, PCH_Pc18g00730
GN {ECO:0000313|EMBL:CAP94297.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP94297.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP94297.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000256|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000256|HAMAP-
CC Rule:MF_03013}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM920433; CAP94297.1; -; Genomic_DNA.
DR RefSeq; XP_002561919.1; XM_002561873.1.
DR AlphaFoldDB; B6HBY9; -.
DR STRING; 500485.B6HBY9; -.
DR GeneID; 8314620; -.
DR KEGG; pcs:Pc18g00730; -.
DR VEuPathDB; FungiDB:PCH_Pc18g00730; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR OMA; HPVWDKD; -.
DR OrthoDB; 927222at2759; -.
DR BioCyc; PCHR:PC18G00730-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c18.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601:SF6; CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR12601; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR Pfam; PF13374; TPR_10; 2.
DR Pfam; PF13424; TPR_12; 1.
DR SUPFAM; SSF103107; Hypothetical protein c14orf129, hspc210; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03013};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_03013};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT DOMAIN 321..565
FT /note="Clu"
FT /evidence="ECO:0000259|PROSITE:PS51823"
FT REPEAT 964..997
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1240 AA; 137509 MW; 423D4C1184E86D79 CRC64;
MQGTRANGGT EAPQASQEIA NGTAPEGTEE DNAGGLFQIS VKLPHAPHKI QVMVSSQEQV
QDVRQSIVEL PGTFQYTCFH LEFNGNRIND FVELSEVPDL QADSEIVLVE DPYTEKEARM
HVVRIRELIG ASGDRVDNLH GISAGLSLHD AITADAIKAS ESEKEHSLSK YDLTGVSPLQ
TILPTAEAPL PKTVKSISLS AWNPVPYNLR QKGHLLYLVV ATNEGEQFQI TAHVSGFFVN
KCSSVRFDPF PKQTHPKKGS AHSLLTLISQ LSPSFNASFE ALQEYNNEKD LLTTFPFQNA
IPNSPWLIAP SNSSLNAHQP DITRSQENYL ISGVDNAETL RDWNEEFQTT RELPRESVQD
RVFRERLTSK LFADYNEAAA RGAVLVARGE VAPLNPTEAR DAQIFVYNNI FYSFGADGVG
TFTSEGGDEA ARVAVGKDVL GIKAVNQLDI DGLFTPGTVV VDYLGKRIVG QSIVPGIFKQ
REPGEHQIDY GGVEGKEVVA THADFVPVFE KLSKALRVKQ HPVWDKENQR HDLEGSVETK
GLLGTDGRKY VLDLYRIAPL DAEWQEEEGS DVYPHRMSVL RLELVESYWR HKMSQYVKAE
VESRKAASAE AAKEGKTEEE GADQERVDIS GFNLALNPDV FSGQVPQTQE EKEQWAKDEQ
EVRDACDHLR SKVIPDLLKD LHDGDVGFPM DGQSLTQLLH KRGINIRYLG KLAQQSAEKG
PRLQALSILL VQEMITRAFK HVANRYLNNV PAPFVASCLS HLLNCLLGSD VNATPKAEID
ESLRAIFPEG DFSFEKVTPE SLRAELEKQV TIRFRFSLEK DWANSLRHLQ LLRDISVKLG
LQIGAREFAF TKDQVKEQVV VPATNGSTHE EPKKKGKKKG GDNKSPARTA PAPAKPAVTF
TTDDILNVVP LVRDAAPRSA LAEEALEAGR ISLMQNQKQL GQELILESLS LHEQIYGILH
PEVAKLYHQL SMLYYQTDEK EAAVELARKA VIVTERTMGV DSADTILSYL NLSLFEHASG
NTKTALVYIK HAMDVWKIIY GPNHPDSITT MNNAAVMLQH LKQYNDSRKW FEASLSICEE
LFGKDSINTA TILFQLAQAL ALDQDSKAAV GKMREAYNIF LAQLGPEDRN TKEAENWLEQ
LTQNAVSIAK HAKDIQARRL RRNPLNPRVS SMGTRVQPQV GQTAPEISAP ADPSGLDSRS
IDELLKFIEG TDTSSSRSKQ KKRAATSNPK LRGSKQSNKA
//
