ID B6HJ58_PENRW Unreviewed; 750 AA.
AC B6HJ58;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
GN ORFNames=Pc21g23700 {ECO:0000313|EMBL:CAP97267.1}, PCH_Pc21g23700
GN {ECO:0000313|EMBL:CAP97267.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP97267.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP97267.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation.
CC {ECO:0000256|ARBA:ARBA00003842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920,
CC ECO:0000256|PIRNR:PIRNR028937};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|PIRNR:PIRNR028937}.
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DR EMBL; AM920436; CAP97267.1; -; Genomic_DNA.
DR RefSeq; XP_002569337.1; XM_002569291.1.
DR AlphaFoldDB; B6HJ58; -.
DR GeneID; 8310242; -.
DR KEGG; pcs:Pc21g23700; -.
DR VEuPathDB; FungiDB:PCH_Pc21g23700; -.
DR eggNOG; ENOG502QSD8; Eukaryota.
DR HOGENOM; CLU_008878_3_1_1; -.
DR OMA; GCPTNAK; -.
DR OrthoDB; 601859at2759; -.
DR BioCyc; PCHR:PC21G23700-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c21.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF4; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 2.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR028937};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 221..258
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 269..494
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 565..727
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT ACT_SITE 674
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
SQ SEQUENCE 750 AA; 81269 MW; 08414D0D68F3FA2F CRC64;
MPAVSTYTPR DVPLPPAPSA TYFSELQWKT LYALADALVP SIHTAATAKS SNDRVISDAE
WNSAVFSLST VISGPDAVNI ATQYLHENVS SNPQFRAIVE RLLGDYVHDE GRNGFGFILT
ALNTRAGSLI ITGSTTPIQD QPVEFREKVV RGWDTSRLPP LRAIYRGLTA IVKKCWIITS
PTIGPVLGFP RLPAHGKHAD GFQYEFLQFP PGDQPETIET DVVIVGSGCG GSVTAKNLAE
AGHRVLVVEK SYSYPSNTFP MGPNEGFVNM FENGGAISSD DGSMAVLAGS TWGGGGTVNW
SASLQTQGYV RQEWADAGLP FFTSLDFQKS LDRVCHRMGV NEEHVEHNHQ NRVILEGARK
LGYAAKTVPQ NTGHGEHYCG YCTLGCASGG KKGPTESFLV DAAQAGASFM EGFCVEKVLF
TNVNGRKVAS GVQGTWKSRD SHLGLGGIAA VERKVIIKAK KVVISAGTLQ SPLLLLRSGL
NNPQIGRNLY LHPVMGAGAV FNEETHPWEG SALTTVVNEF EDLDGNGHGV KIESVSMMPS
VFIPIFPWRD SLEYKLWAAK MRRSTSFITL TKDRDTGRVY PDPVDGRCRI DYTVSAFDRK
HIVEAMIACA KIAYITGATE FHTVYRDLPP FIRPETSDPE APDGTNDAAL QNWIDELRRK
SPLNPGRGLF ASAHQMGTCR MSKSPKLGVV DPNCQVWGTD GLYVVDASVF PSASGVNPMV
TNMAIADWAS RNLARAMGTV RGEGSLIARL
//
