ID B6HVB3_PENRW Unreviewed; 419 AA.
AC B6HVB3;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Pc22g14760 protein {ECO:0000313|EMBL:CAP98764.1};
GN ORFNames=Pc22g14760 {ECO:0000313|EMBL:CAP98764.1}, PCH_Pc22g14760
GN {ECO:0000313|EMBL:CAP98764.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP98764.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP98764.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC Mediator complex. {ECO:0000256|ARBA:ARBA00011612}.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR EMBL; AM920437; CAP98764.1; -; Genomic_DNA.
DR RefSeq; XP_002565397.1; XM_002565351.1.
DR AlphaFoldDB; B6HVB3; -.
DR STRING; 500485.B6HVB3; -.
DR GeneID; 8308701; -.
DR KEGG; pcs:Pc22g14760; -.
DR VEuPathDB; FungiDB:PCH_Pc22g14760; -.
DR eggNOG; KOG2496; Eukaryota.
DR HOGENOM; CLU_022620_4_1_1; -.
DR OMA; AKKLYHC; -.
DR OrthoDB; 5481790at2759; -.
DR BioCyc; PCHR:PC22G14760-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c22.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20524; CYCLIN_CCNH_rpt1; 1.
DR CDD; cd20525; CYCLIN_CCNH_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 1.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR031658; Cyclin_C_2.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF8; CYCLIN-H; 1.
DR Pfam; PF16899; Cyclin_C_2; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 85..178
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 49..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 47041 MW; 2ADCA9FDB27B7CAE CRC64;
MIEDDIYRAS SQYRLWSYTE PSLQSLRATT NAVASERVRA ALRRSCEAHQ STATSAAGTP
LPESNMEVKN KDEKDVECLT PEEELVLVRY YCEKTLELGE TYKPPIPTMV RATAIQYLRR
FYLTNSPMTY HPKSIMACAL FVATKTDNYY ISLRQFADGI PGDTTTEDVI APEFLLMQGL
RFTFDVRHPF RGLEGGVLEL QAIAQGQGQP APHLPYETAE DLQQGLLSIA PPPVPSSSMS
DRIARAHGTT RELLKSAAQM TDAYFLYTPS QIWFSAFLLA DRPLAEFLLD VKLAPETDEN
GLVNPLYEIR SKLHHVLTEC SALLQSYTPL SSDPAQMKSL KRIAKKLYHC QNPEKVNLAA
AQKRESTQPS TAVQSDAGIV TSESETERLA KKRKLEQEQK VRQEDDVFGP ELVTQRTKQ
//
