ID   B6JPS7_HELP2            Unreviewed;       340 AA.
AC   B6JPS7;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Sialic acid synthase {ECO:0000313|EMBL:ACJ07338.1};
GN   OrderedLocusNames=HPP12_0178 {ECO:0000313|EMBL:ACJ07338.1};
OS   Helicobacter pylori (strain P12).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=570508 {ECO:0000313|EMBL:ACJ07338.1, ECO:0000313|Proteomes:UP000008198};
RN   [1] {ECO:0000313|Proteomes:UP000008198}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P12 {ECO:0000313|Proteomes:UP000008198};
RA   Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.;
RT   "The complete genome sequence of Helicobacter pylori strain P12.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACJ07338.1, ECO:0000313|Proteomes:UP000008198}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P12 {ECO:0000313|EMBL:ACJ07338.1,
RC   ECO:0000313|Proteomes:UP000008198};
RX   PubMed=20478826; DOI=10.1093/nar/gkq378;
RA   Fischer W., Windhager L., Rohrer S., Zeiller M., Karnholz A., Hoffmann R.,
RA   Zimmer R., Haas R.;
RT   "Strain-specific genes of Helicobacter pylori: genome evolution driven by a
RT   novel type IV secretion system and genomic island transfer.";
RL   Nucleic Acids Res. 38:6089-6101(2010).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001217; ACJ07338.1; -; Genomic_DNA.
DR   RefSeq; WP_000941836.1; NC_011498.1.
DR   AlphaFoldDB; B6JPS7; -.
DR   KEGG; hpp:HPP12_0178; -.
DR   HOGENOM; CLU_040465_0_1_7; -.
DR   Proteomes; UP000008198; Chromosome.
DR   GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR   CDD; cd11615; SAF_NeuB_like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR   InterPro; IPR006190; AFP_Neu5c_C.
DR   InterPro; IPR036732; AFP_Neu5c_C_sf.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013132; Neu5Ac_N.
DR   InterPro; IPR020030; Pseudaminic_synth_PseI.
DR   InterPro; IPR013974; SAF.
DR   NCBIfam; TIGR03586; PseI; 1.
DR   PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR   PANTHER; PTHR42966:SF2; PSEUDAMINIC ACID SYNTHASE; 1.
DR   Pfam; PF03102; NeuB; 1.
DR   Pfam; PF08666; SAF; 1.
DR   SMART; SM00858; SAF; 1.
DR   SUPFAM; SSF51269; AFP III-like domain; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50844; AFP_LIKE; 1.
PE   4: Predicted;
FT   DOMAIN          281..339
FT                   /note="AFP-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50844"
SQ   SEQUENCE   340 AA;  37915 MW;  88D63A9B1F864B6F CRC64;
     MLQRPKIVAE LSANHNQDLN LAKESLHAIK ESGADFVKLQ TYTPSCMTLN SKEDPFIIQG
     TLWDKENLYE LYQKASTPLE WHAELFELAR KLDLGIFSSP FSSKALELLE SLNCPMYKIA
     SFEIVDLDLI EKAARTKKPI ILSSGIATHT ELQDAISLCK EVGNFDITLL KCVSAYPSQI
     EDANLLSMVK LGETFGVKFG LSDHTIGSLC PILATTLGAS MIEKHFILNK SLQTPDSAFS
     MDFNGFKSMV EAIKQSVLAL GEEEPKINPK TLEERRFFAR SLFVIKDIQK GEALTENNIK
     ALRPNLGLHP KFYKEILGQK ASKFLKANTP LSADDIERSL
//