ID B6K5B6_SCHJY Unreviewed; 926 AA.
AC B6K5B6;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Upf1 domain-containing protein {ECO:0000259|PROSITE:PS51997};
GN Name=upf1 {ECO:0000313|JaponicusDB:SJAG_03886};
GN ORFNames=SJAG_03886 {ECO:0000313|EMBL:EEB08720.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08720.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB08720.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; KE651167; EEB08720.1; -; Genomic_DNA.
DR RefSeq; XP_002175013.1; XM_002174977.1.
DR AlphaFoldDB; B6K5B6; -.
DR STRING; 402676.B6K5B6; -.
DR EnsemblFungi; EEB08720; EEB08720; SJAG_03886.
DR GeneID; 7050523; -.
DR JaponicusDB; SJAG_03886; upf1.
DR VEuPathDB; FungiDB:SJAG_03886; -.
DR eggNOG; KOG1802; Eukaryota.
DR HOGENOM; CLU_001666_4_3_1; -.
DR OMA; VRSNDNQ; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR GO; GO:2000815; P:regulation of mRNA stability involved in response to oxidative stress; IEA:EnsemblFungi.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 38..195
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 46..78
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 60..88
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 106..136
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 903..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 103895 MW; 930E8E1194F9307C CRC64;
MLQEGMEQNA ALYSYSGGAD HEDVVNFTMN ELSHLQVSED QEHESCAYCG LSNPSAIVKC
LHCNKWFCNS RGHTSASHIV THLVRARHKQ VSLHKNSPLG ETVLECYNCG TRNVFLLGLI
PAKSDTVIVL LCRQPCTKVS LAKDMNWDVS QWQPLITDRQ FLPWLVLPAT KEEEMAARPI
TSQQISRLEE LWHENANASL EDLEKPTVSE NLPSVDLRFP DARAYQAAFS PLVQVEAEYD
KKLKESQTQN DVVVRWDQSL NQRYTAWFYL PKLESGEIRL AVSDEMKLRY EGELRPKWSS
TGYVIKIPNN ISDEVGLELN RSDKIPIECT HNFSVDYVWK STSFDRMQAA LKSFATDNSR
LSGYLYHKLL GHEVPPLTLK TKLPTTFSVP NLPELNSSQV NAVRSVLTQP LSLIQGPPGT
GKTVTSASIV YHLATQTKGN GSAVLVCAPS NVAVDQLAEK IHQTGLRVVR VTAKSREDID
SPVSFLSLHE QVKNYEGNEE FSRLLKLQND VGELSLADEK RLRVLVASIE RELLQSANVI
CCTCVGAGDK RVSKLRFRAV LIDEATQASE PECMIPLTHV YKQVVLVGDH QQLGPVVMNK
KAAQAGLSQS LFERLIILGN SPIRLTVQYR MHPCLSEFPS NMFYEGTLQN GVTTAERLAR
YLDFPWPQPE EPLMFYANFG QEEISASGTS YLNRTEASTC EKIVTQFFKA GVTPEQIGII
TPYDGQRSYI VQYMQNNGAL KKDLYKAVEV ASVDAFQGRE KDFIILSCVR SSEHQGIGFL
SEPRRLNVAL TRARYGVIVL GNPKVLAKHA LWYHFIVHCR ERGYLVEGPL NNLQKFMLGL
APPIKPLKLP RNLVAQQPLS AGISAFTINT FAPFINLQNY YAVPSYIDEW SRLAESKRHD
NGGADLDDFQ SQIGDNESDY GDITRF
//
