ID B6SBC7_9HEPC Unreviewed; 174 AA.
AC B6SBC7;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Protease-helicase {ECO:0000313|EMBL:ACH97494.1};
DE Flags: Fragment;
GN Name=NS3 {ECO:0000313|EMBL:ACH97494.1};
OS Hepacivirus hominis.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Hepacivirus.
OX NCBI_TaxID=3052230 {ECO:0000313|EMBL:ACH97494.1};
RN [1] {ECO:0000313|EMBL:ACH97494.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7G74R317S3 {ECO:0000313|EMBL:ACH97494.1};
RX PubMed=19263475; DOI=10.1002/hep.22773;
RA Gaudieri S., Rauch A., Pfafferott K., Barnes E., Cheng W., McCaughan G.,
RA Shackel N., Jeffrey G.P., Mollison L., Baker R., Furrer H., Gunthard H.F.,
RA Freitas E., Humphreys I., Klenerman P., Mallal S., James I., Roberts S.,
RA Nolan D., Lucas M.;
RT "Hepatitis C virus drug resistance and immune-driven adaptations: Relevance
RT to new antiviral therapy.";
RL Hepatology 0:0-0(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; EU710490; ACH97494.1; -; Genomic_RNA.
DR MEROPS; S29.001; -.
DR euHCVdb; EU710490; -.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR004109; HepC_NS3_protease.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR Pfam; PF02907; Peptidase_S29; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:ACH97494.1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Helicase {ECO:0000313|EMBL:ACH97494.1};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000313|EMBL:ACH97494.1};
KW Protease {ECO:0000313|EMBL:ACH97494.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1..174
FT /note="Peptidase S29"
FT /evidence="ECO:0000259|PROSITE:PS51822"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACH97494.1"
FT NON_TER 174
FT /evidence="ECO:0000313|EMBL:ACH97494.1"
SQ SEQUENCE 174 AA; 18486 MW; 9095D590F42F80B4 CRC64;
QQTRGLLGCI ITSLTGRDKN QVEGEVQIVS TATQTFLATC INGVCWTVYH GAGTRTIASP
KGPVIQMYTN VDQDLVGWPA PQGARSLTPC TCGSSDLYLV TRHADVIPVR RRGDSRGSLL
SPRPISYLKG SSGGPLLCPA GHVTGIFRAA VCTRGVAKAV DFIPVENLET TMRS
//
