ID   B6UXS7_DROSI            Unreviewed;       633 AA.
AC   B6UXS7;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=RAD50 {ECO:0000313|EMBL:ACI97310.1};
DE   Flags: Fragment;
GN   Name=rad50 {ECO:0000313|EMBL:ACI97310.1};
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240 {ECO:0000313|EMBL:ACI97310.1};
RN   [1] {ECO:0000313|EMBL:ACI97310.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Md106 {ECO:0000313|EMBL:ACI97310.1};
RX   PubMed=18984573; DOI=10.1534/genetics.108.093807;
RA   Anderson J.A., Gilliland W.D., Langley C.H.;
RT   "Molecular population genetics and evolution of Drosophila meiosis genes.";
RL   Genetics 181:177-185(2009).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009439}.
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DR   EMBL; FJ219325; ACI97310.1; -; Genomic_DNA.
DR   GO; GO:0000793; C:condensed chromosome; IEA:EnsemblMetazoa.
DR   GO; GO:0030870; C:Mre11 complex; IEA:EnsemblMetazoa.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; IEA:EnsemblMetazoa.
DR   GO; GO:0008104; P:protein localization; IEA:EnsemblMetazoa.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblMetazoa.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR   PANTHER; PTHR18867; RAD50; 1.
DR   Pfam; PF13476; AAA_23; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          1..231
FT                   /note="Rad50/SbcC-type AAA"
FT                   /evidence="ECO:0000259|Pfam:PF13476"
FT   COILED          165..230
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          284..318
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          412..477
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          559..614
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACI97310.1"
FT   NON_TER         633
FT                   /evidence="ECO:0000313|EMBL:ACI97310.1"
SQ   SEQUENCE   633 AA;  73358 MW;  B4D90293902BD302 CRC64;
     IKFSSPVTLI LGENGCGKTT VVECLKYALT GECPPGSDRG KSFVHDPKIF GLNEVLAQIK
     MQVRDRRGAQ VSICRTMKVS KKRNKMSFET MDSTINFLTG AGQSKREKQD SLSGRSVDID
     VAISDFMGVS KAIINNVLFC HQEDSSWPLD ESKKLKEKFD AIFGITEYNK ALDKIIKLRK
     EAMEELKIKE ANMKHVAYLK QEMEVKTLNL QKAQRKCDAI KAQCSECEEE MKPIEARLVE
     IRNVEFEIGK YQAQKVEMDT KHKNCKDQIS TLTLKIKNPF RGTLDELDQE IINFDQRMQE
     MRQKRTEVEG NLSQIKRSSV AEQEKLGTQD RKHCLAKQRH QSELACRAQL XKRVKEFCRE
     LHINIDCDLV EQPEKMGEVL QDIEAMIITK HCEITEIVEQ NEKADRSRQV KIDELRIDLT
     KSEQSVTAQE KQRESSKRES ETLGVEIKKI ETSMQDLKKL EKEINEVNEL YESANKSIDQ
     QAIKDAIARK KASIAENQIQ FKKLDEQLTF LGSMAKLVAE CSLKQKELDK KNQEVHRVRS
     RHSDHFGKLF KEPITCNYRR SMQVVYEKLR REIQDLNEKA NTQKLKEQSY EIKRKNLISD
     ISRMEKELKD SEELIYQKCR STPYDDLLER SKT
//