UniProt: B7I0Z5

Database: UniProt
Entry: B7I0Z5_BACC7

LinkDB:  B7I0Z5_BACC7 
Original site:  B7I0Z5_BACC7

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Ontology (9)   
   GO (9)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (27)   
   InterPro (16)   
   Pfam (6)   
   PROSITE (3)   
   SMART (2)   
All databases (38)   

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ID   B7I0Z5_BACC7            Unreviewed;      2681 AA.
AC   B7I0Z5;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Linear gramicidin synthetase subunit B {ECO:0000313|EMBL:ACJ82785.1};
DE            EC=5.1.1.- {ECO:0000313|EMBL:ACJ82785.1};
GN   OrderedLocusNames=BCAH187_C0023 {ECO:0000313|EMBL:ACJ82785.1};
OS   Bacillus cereus (strain AH187).
OG   Plasmid pAH187_270 {ECO:0000313|EMBL:ACJ82785.1,
OG   ECO:0000313|Proteomes:UP000002214}.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=405534 {ECO:0000313|EMBL:ACJ82785.1, ECO:0000313|Proteomes:UP000002214};
RN   [1] {ECO:0000313|EMBL:ACJ82785.1, ECO:0000313|Proteomes:UP000002214}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AH187 {ECO:0000313|EMBL:ACJ82785.1,
RC   ECO:0000313|Proteomes:UP000002214};
RC   PLASMID=Plasmid pAH187_270 {ECO:0000313|Proteomes:UP000002214};
RA   Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B.,
RA   Okstad O.A., Ravel J., Sutton G.;
RT   "Genome sequence of Bacillus cereus AH187.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; CP001179; ACJ82785.1; -; Genomic_DNA.
DR   SMR; B7I0Z5; -.
DR   KEGG; bcr:BCAH187_C0023; -.
DR   HOGENOM; CLU_000022_11_0_9; -.
DR   Proteomes; UP000002214; Plasmid pAH187_270.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd12117; A_NRPS_Srf_like; 1.
DR   CDD; cd08953; KR_2_SDR_x; 1.
DR   CDD; cd19531; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Isomerase {ECO:0000313|EMBL:ACJ82785.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Plasmid {ECO:0000313|EMBL:ACJ82785.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1279..1354
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2327..2401
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2681 AA;  304305 MW;  8CA73A5EE74F0C6E CRC64;
     MLSTRKNLHA NLVRIQGKRV DLKKIERQVA KVSFIEQCAV IARKQDDGEY LLTAFVVSEK
     AAAKEELQLL EVLPPKSQII SMSSLPLTKE GTIDRQQLMS LLCITADEEM RLQQSYGKEK
     MAITYEEVFR LPNVNHVYDV MKVKETSQKV VSREKQAKEH FAQHIPAYMV GEDLTQFDMS
     QEPKTLVEVI HNAAKNYGNH GITFIDEHGK TEFLTYKMIL MEAERMLKGL RAFQLQPQDK
     IIFQMNNDKV FVITFWACVL GGFIPVPITV PKMFTQRTNE ADTLYNIWRA LEKPYIVTNE
     TLQDSMTQLL DCYDLDAAKY LAFEKIQQEE PDQNWHVAQS EDDAILLFTS GSTGNPKGVV
     QKHRSILTRE ISTSKYNHFS AHDIALNWMP LEHVGGIVMF HIKDTYLGRN QVQVRTQYVL
     SEPTRWLDLI TTYKATITWA PNFAFALINK EIENGVKGNW DLSSMEFIVN AGEAINGYTA
     KKFLQVLSPY GLPEDAMIPV WGMSETCSGV VYNKAFRSDG TKGLFIVDKQ SLEGIIQEGN
     NVEDTITFVN LGKPIYGVSI RIANQDNETV AEGVIGRLQI KGKNVLEGYY QNEEANKECF
     TEDGWYDTGD LAFIKDGCMA ITGRGKDIII INGVNFNGTE IEYVVEQVAG VKTSFVAACA
     VRDDQLDTDE LAIFYSTMCA NDEEIREQIQ EIDQTIIEKF GVKASYIIPV EEEEIPKTNI
     GKIQRTKLSN QFRLGYYEKL SKEIDILLQN DRTIPAWFYE QGFVRKETEI TFNPKETRKI
     VIVGESTAFV TTIKRKLEEV GHHCYLVGNR EAYLSILKQE EIDDVINLLN YEKQDADGNE
     IEKIRNANEN GIFFISETIK ACGKEKNLRI FTVTNNCEYS NIMKNKYHFG TLDGFSRSVN
     LELPNLMCIR IDLDVSENDV NSIIKEIAAI HRDDKVVYRE GKRYVDSLQP IDMPLSLQNE
     IALIKDGIYV VTGGLGGIGK EVCKLLLQQF SAKLFIVGRT ALSTSPTHLA SLEELQGFSK
     DVHYIDGDLS DAAFVASISA KVEEIWGTEL DGILHLAGAG NLEEHWSEID SHWCTTESKA
     YYEEMFAAKV FGTVNLFQLI EGKKDALFLH FSSVNSYFGG ASFTAYAAAN NFQDTFCQYV
     SNQGYKNAIC INWSMWYDIG MSRNNTNNEL MAEKGFLLLP MKQAVYSLLA VLRTGVNNIF
     VGLDASKSNI RKSMKQKKEL GLKAIVYHTD EVSDLSIEAK KHVSFLKVDE IPIDEKGCVQ
     IGKLQDLHKN VGKTEMFQEP QSEAEKTLAK IWRDVLKANK IGRDSNFFEL GGHSINATQL
     VSKIYSVCRV RMPLKNVFQY TTLATMARVL EELLVSAVDE VAVTTERIPK ILPRTYYDLS
     YSQQRIYFLS TMEKETNYYN ILGAWDIYGK LDVTLFEKAI QLLMKKHHSL RATFEIVDGK
     PVQIIHDDME IPVQFIDLTV MPEGLRIEEV DELMLKESKR VYNLANGPLM HCTIVKIKEG
     EHVLLIGQHH IISDGWSLGI FVKELNEMYD AFVQHKPVAE TPSTISIMDF TAWHNSKVDE
     DQDDRQYWLQ RFEGELPTLE LPTDRQRPLL KTYHGDTLSY KVNSQLHQKL KDFSHANGVT
     MFMTLLTAYN IMLNKLTNET DIVVGSPVAG RNEPESKDLI GMFVNTLALR SHLGDNPTVD
     VLLKQIKQNT LEAYNHQDYP FDKLVDDLDP HRDLSRTPIF QVMMGYMNMP LMVAFREAEV
     RERFVRHKVA RFDLTLHVFE DEDQMKIFFE YNTDLFDEST IMRWQNHFET LLQEIVSNPT
     KRISELNILT NEEKYEILEM NNNSTEYPQH ESVAEIFRET KIKHQAKLAI TYKDRKLTYA
     ELSEKANALA HTLKRRGVAQ HDVVGIVAER SPETIIGILA ILKVGAIYLP IDPKLPQLTL
     QHIWRDSGAK VLLGKNETTV EVGKEVPFVD IEGDKGKQEE LVCPISPEDT AYIMYTSGST
     GKPKGVMVTH RNIVRLVKNT NFVSLQEQDV LLQTGSLTFD AATFEIWGAL LNGLTLHLVE
     DYVILDGEAL QEEIQQNKAT IMWVSAPLFN QLADQNPAMF TGIKQLLIGG DVLSPKHINK
     VMDHCAPINI INGYGPTENT TFSTSFVIDQ MYQDSIPIGT PIANSSAYIL DVHQNIQPIG
     VVGELCVGGD GVAKGYVNLE QLTEERFIAD PFLKGSTMYR TGDYVKLLPN GNIQYIGRVD
     NQVKIRGFRI ELEAIMNTLK QCESIKDVIV VVQEQNGYKT LVAYVVGEES LSIETVRAYA
     KKHLAEYMVP SQFIFIEEIP LSINGKVQYS KLPKVQEVLH KKVETLLPEN RLEEIILRVY
     RDVLEKEDFG VTDSFFAYGG DSLLSIQVVS MLKKEEIAVD PKMIFMHTTV RELAKACENR
     PVMEETKRTE KDYLIQMREG SEEDSCIIFA PPAGGTVLGY IELARYFEGI GNVYGLQAPG
     LYDDEEPTFL DYDELVQVFL RSIEGTYRPG QDYLGGHSLG GHIAFGMCCE LIKQGKAPKG
     LLILDTTPSL QVVKGAKDEK IAEEDFKMMV LAAGIGNMMG VDPEELKQLS YEEAKTRVVA
     VAQKDEKLKT FINETYLDKY LKLQIHSLLM SRTLELEKTQ LDIPIKVFKT QFHTEELVER
     FDAWHNYTNQ ACTFIDIPGT HTTMMRLPHV KEVAKKIEEQ L
//

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