ID   B7ICL5_THEAB            Unreviewed;       864 AA.
AC   B7ICL5;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Mmpl family {ECO:0000313|EMBL:ACJ75742.1};
GN   OrderedLocusNames=THA_1297 {ECO:0000313|EMBL:ACJ75742.1};
OS   Thermosipho africanus (strain TCF52B).
OC   Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC   Thermosipho.
OX   NCBI_TaxID=484019 {ECO:0000313|EMBL:ACJ75742.1, ECO:0000313|Proteomes:UP000002453};
RN   [1] {ECO:0000313|EMBL:ACJ75742.1, ECO:0000313|Proteomes:UP000002453}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TCF52B {ECO:0000313|EMBL:ACJ75742.1,
RC   ECO:0000313|Proteomes:UP000002453};
RX   PubMed=19124572; DOI=10.1128/JB.01448-08;
RA   Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D.,
RA   Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.;
RT   "The genome of Thermosipho africanus TCF52B: lateral genetic connections to
RT   the Firmicutes and Archaea.";
RL   J. Bacteriol. 191:1974-1978(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP001185; ACJ75742.1; -; Genomic_DNA.
DR   RefSeq; WP_012580128.1; NC_011653.1.
DR   AlphaFoldDB; B7ICL5; -.
DR   STRING; 484019.THA_1297; -.
DR   KEGG; taf:THA_1297; -.
DR   eggNOG; COG1033; Bacteria.
DR   HOGENOM; CLU_008861_1_1_0; -.
DR   OrthoDB; 9809027at2; -.
DR   Proteomes; UP000002453; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        321..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        706..722
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        729..751
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        757..779
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        806..825
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        831..857
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          225..348
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   DOMAIN          729..856
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   864 AA;  97444 MW;  29A74F3CDE102855 CRC64;
     MEKLGRFVQK NAIWVVLITV LLTVFFSYEI KDLQIQDDIT KYPPKDDPLV RKYDSLAREF
     GINSMLMVGF SIDSFNDLKA IDNLTQEISK LEGVEHVTSL TNIPLVVETD YGIEVSTVSE
     ILKTRDINPT YLLKYKTLKD KFISDDAKAG LMLVSLESGK ESETFSRLKE VIENKYPKDV
     HFFGVAAVNE AVKEITLKNI LRLVPISIFI VILILSVTFR KISGAILPIL GVIVSVIWTM
     GLIALFGFNI TVANSIIPVA LISIGTAYSI HVVNKYYEEK GERAQRVVST ISDVGLAVIL
     SGLTTAVGFL SLLTADIKPV WIMGIFSSIG VMLCNFIALF FVPALLYYIN PKPVFHVENK
     NHSKLILKPK LTISILIILA IVSIPFLLRI KTDMDIVNSL NPNERIIVDK EFLDENFGGS
     DYLFVDIKGD FKDPSTLIAM NEIERKLNKI PGVVNTFSIV DTILDLSEAF TGFYSIPFSK
     NELSNLWFFL LGNDTIYSVV NKDLSRGIIQ VTVKTKSESE TRRLLEEIDK VLNSTPKGFK
     ASNDIDFKYY SNLLNVETIN LRKVYEAVKN VSFSTLLKLH REDILNSIRH IEEMYGFSVD
     DKEEVLKRVI NLKDFSEEEF EKIMEDDPDF GYALYNELYL SVKKWKAMYF ADQLNISYDK
     NTEQYLKIVA EDSVYNPSDQ PTYSAVHTGA QEIALYVSDL LFKNQYQSML LTLLVVFLLL
     LLQMRSFKVG VIGIIPSIFT VFFNFALMGM FNIPLNTATI SIAAIAIGAG VDYAIHFISR
     FKIESKRIKD SKTAIIRTIY TSGRGILFNA LAVSFGFFTF FFSSIRMLRQ FGVLTGITLL
     LSAIITILFL SSAFLLINKG GRKS
//