ID B7IM50_BACC2 Unreviewed; 245 AA.
AC B7IM50;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=glucose-1-phosphate thymidylyltransferase {ECO:0000256|ARBA:ARBA00012461};
DE EC=2.7.7.24 {ECO:0000256|ARBA:ARBA00012461};
GN OrderedLocusNames=BCG9842_B4074 {ECO:0000313|EMBL:ACK95068.1};
OS Bacillus cereus (strain G9842).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=405531 {ECO:0000313|EMBL:ACK95068.1, ECO:0000313|Proteomes:UP000006744};
RN [1] {ECO:0000313|EMBL:ACK95068.1, ECO:0000313|Proteomes:UP000006744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G9842 {ECO:0000313|EMBL:ACK95068.1,
RC ECO:0000313|Proteomes:UP000006744};
RA Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA Ravel J., Sutton G.;
RT "Genome sequence of Bacillus cereus G9842.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate +
CC dTDP-alpha-D-glucose; Xref=Rhea:RHEA:15225, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37568, ChEBI:CHEBI:57477,
CC ChEBI:CHEBI:58601; EC=2.7.7.24;
CC Evidence={ECO:0000256|ARBA:ARBA00001095};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the glucose-1-phosphate thymidylyltransferase
CC family. {ECO:0000256|ARBA:ARBA00010480}.
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DR EMBL; CP001186; ACK95068.1; -; Genomic_DNA.
DR RefSeq; WP_000676159.1; NC_011772.1.
DR AlphaFoldDB; B7IM50; -.
DR KEGG; bcg:BCG9842_B4074; -.
DR HOGENOM; CLU_029499_9_0_9; -.
DR Proteomes; UP000006744; Chromosome.
DR GO; GO:0008879; F:glucose-1-phosphate thymidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR005907; G1P_thy_trans_s.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43532; GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43532:SF1; GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 1; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000313|EMBL:ACK95068.1}.
FT DOMAIN 2..231
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 245 AA; 27435 MW; 7DA68FFABA6E0F0D CRC64;
MKGIILAGGT GSRLYPITKV TNKHLLPVGR YPMIYHAVYK LKQCDITDIM IITGKEHMGD
VVSFLGSGHE FGVSFTYRVQ DKAGGIAQAL GLCEDFVGND RMVVILGDNI FSDDILPYVE
EFANQKEGAK VLLQSVEDPE RFGVAHIQNR KIVEIEEKPK EPKSSYAVTG IYLYDSKVFS
YIKELKPSAR GELEITDINN WYLKRGVLTY NEMSGWWTDA GTHASLQKAN TLARDIDFGK
QFNGE
//
