ID B7J4X6_ACIF2 Unreviewed; 879 AA.
AC B7J4X6;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Membrane protein, putative {ECO:0000313|EMBL:ACK78141.1};
GN OrderedLocusNames=AFE_2118 {ECO:0000313|EMBL:ACK78141.1};
OS Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768
OS / NCIMB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270)).
OC Bacteria; Pseudomonadota; Acidithiobacillia; Acidithiobacillales;
OC Acidithiobacillaceae; Acidithiobacillus.
OX NCBI_TaxID=243159 {ECO:0000313|EMBL:ACK78141.1, ECO:0000313|Proteomes:UP000001362};
RN [1] {ECO:0000313|EMBL:ACK78141.1, ECO:0000313|Proteomes:UP000001362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455
RC {ECO:0000313|Proteomes:UP000001362};
RX PubMed=19077236; DOI=10.1186/1471-2164-9-597;
RA Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R.II.,
RA Eisen J.A., Holmes D.S.;
RT "Acidithiobacillus ferrooxidans metabolism: from genome sequence to
RT industrial applications.";
RL BMC Genomics 9:597-597(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001219; ACK78141.1; -; Genomic_DNA.
DR AlphaFoldDB; B7J4X6; -.
DR STRING; 243159.AFE_2118; -.
DR PaxDb; 243159-AFE_2118; -.
DR KEGG; afr:AFE_2118; -.
DR eggNOG; COG1033; Bacteria.
DR HOGENOM; CLU_009099_0_0_6; -.
DR Proteomes; UP000001362; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001362};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 269..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 294..420
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 879 AA; 94000 MW; 85C97196E274BCB1 CRC64;
MALVDLSVQR AAWMLAAIVL ATLLALGYSV GHFSVDTDTS HALSRDLPFQ KREVAYQKAF
PQDKNTIVVV LQGADRNLTD TAVDRLSTWL RARPQSFHDV YVPGGGPFFQ RNGLLYLSPK
QVQDFANRIT DAQPLIARLS AEPSLNGLSS LLSMAIGQRL TNGVQLPGLT AIFSALDQAL
TAQMQGKSYT ISWGTLMGGD LARMGPSQRF VIIQPALNYK SLEPAAAAIH TLRAGLTSLN
LNAAHGVDVG VTGGAVLDAE QLKTVSQGAA VSLALTFTLE IILLIIALRS LQLVFGVLMG
LIAGMILTTA WALFFIGPFN LISVAFAILF IGLGVDFGIQ FCLRYREEVF NGAVHRQAMQ
RVTQGMGGAL SLAAVAAAFS FFAFVPTSYA GIVDLGLISG TSMLVALFIT LTFLPAFLTL
WPMMVTRTKP TYYPHLRQIP ALVRHPIHRY AYYVLGVVAL LALASVPLVL RTSFDFNPLH
MIDRHAEGVR VFEKLLADPQ TAPYRMEVLT PDIPAAQAVA ARVARLPTVA QALTISSYIP
EHQTEKLAIL QNLQILVPPF SLLMPAGLQP PTPDTAKSLG ELVTKLRALA QKDGENTPDG
QAAAALAGHL AQFLATRGTN AQAIADLQTR VMGTLPGELQ RLGMALSATP VTLQTLPKSL
RDRYVAASGQ ARVEIFPKAN LSSNQAMATF VRSVLKVEPN AVGTPVMLVQ GGDAVLGAFQ
EATFIALIAI SLLLLLALRR YRDVLLIMIP LLLAALFTVA AMTLLGLSFN LGNIIVLPLL
IGLGVAFAIY IVVRWRNGVD VAHLLGTSTP MAVFFSGLTT LSAFGSMAVS RDPGMASLGE
ALSLALAIVL LCILIVLPAL LLLFTPSPRE EGIAQDEGS
//
